Protein Alignment AGO2 and ergo-1

DIOPT Version :9

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_503362.2
• Gene: ergo-1 / 178602
• WormBaseID: WBGene00019971
• Length: 1121
• Species: Caenorhabditis elegans
• Alignment Length: 1227
• Identity: 268/1227 - (21%)
• Similarity: 436/1227 - (35%)
• Gaps: 357/1227 - (29%)

  Fly   194 HQQGRQGQEGGYQQRPPGQQQGGHQQGRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPPGQ 258
            :..|..|..|||:.   .:....|...||      ..|.|.|.:.|:...|  ::..|..|
 Worm     3 YNNGGGGGGGGYRN---DRDDRYHNNDRQ------NYRSSDQGRSGYNDDR--RDNRYDDR---- 52

  Fly   259 QQGGHQQGRQGQEGGYQQRPPGQQQGGHEQGRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQR 323
                  :|.....|.|.|.   .::|.....|:|..        |..|||         |||||:
 Worm    53 ------RGSNNDRGCYDQH---DRRGSSNDDRRGYR--------GYNQGG---------GGYQQQ 91

  Fly   324 PSGQQQGGHQQ------GRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQ----QRPPG------ 372
            .|...:.|..|      ..:|..||....   .|.||::.|..|:.||.:    ...||
 Worm    92 YSQDARYGSNQRNDNYGNNRGSHGGANMY---SQNGGNRGGGGGRVGGGRTAAGMSNPGDLVGGA 153

  Fly   373 QQPNQTQSQGQYQSRGPPQQQQAAPLPLPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYH 437
            .||..:.|:...:...   |:.|.      :|...::...:|:...:..|:..:.|.:.|...:.
 Worm   154 DQPIHSVSKKSLRHNA---QEFAV------RPKTMVQDKGLGQKTTLLTNHTLVQLPQEPITLHV 209

  Fly   438 YDVKIMPERPKKFYRQAFEQFRVDQLGGAVLAYDGKAS-----C--------------------- 476
            :::::.                          .:||:|     |
 Worm   210 FNIEVF--------------------------INGKSSNKRELCGPRFWEILKENKPTFGMPNQY 248

  Fly   477 --------YSVDKLPLNSQNPEVTVTDRNGRTLRYTIEIKETG----DSTIDLKSLTTYMNDRIF 529
                    :|.:||   .|:...|...|.....:|..:||..|    :.|:.|  |:|.: |.|
 Worm   249 IFNDVNMMWSTNKL---RQSEGRTNNRRMNFVWKYVKQIKFGGNIEDEETMQL--LSTLI-DAI- 306

  Fly   530 DKPMRAMQCVEVVLASPCHNKAIRVGRSFFK--------------MSDPNNRHELDDGYEALVGL 580
                 |.|...:.||.|.:        :.||              :.|.:..|:|..|.:|.||:
 Worm   307 -----ATQRARLPLAPPKY--------TVFKRLTYLICEEAYEPELPDVSLCHKLRIGTDARVGV 358

  Fly   581 YQAFMLGDRPFLNV--DISHKSF--PISMPMIEYL-----------ERFSLK--AKINNTTNLDY 628
            ..|.....|..:..  |:.|..|  | :.|::..|           |.|.:|  |.:......|.
 Worm   359 SIAIRTNLRAGITACFDLGHTLFTRP-AYPLVRLLCDIIEHSVVLDEAFEMKYDAALRACNVSDE 422

  Fly   629 SRRFLEPFLRGI----------------NVVYTPPQSFQSAPRVYRVNGLSRAPASSETFEHDGK 677
            :.|.:...|..:                .|:..|..:.::..|.::..||. |||....|..||.
 Worm   423 NLRVMTQILTKMTLQLSTETGDYVGEDGEVIVRPAPTIRNPGRNFKFVGLG-APADRYYFTSDGV 486

  Fly   678 KVTIASYFHSR-NYPLKFPQLHCL------NVGSSIKSILLPIELCSIEEGQALNRKDGATQV-- 733
            ::|:|.|:..: |..|::|.|.|:      ..|:  |...:|:||.|..  ....|..|.|..
 Worm   487 ELTVADYYLQKYNIRLRYPNLPCVLKKAPEQCGN--KHSAMPLELVSYI--VVPTRYGGFTMPDM 547

  Fly   734 -ANMIKYAATSTNVRKRKIMNLL-QYFQHNLDPTIS-------RFGIRIANDFIVVSTRVLSPPQ 789
             |:||.....:...|.:.:.::: |.....::|.:|       :..:.:..:.|.|...:|.||.
 Worm   548 RADMINKTTYTAQQRGKLLQHIIAQKSLSGIEPPVSNNDDYMKKHKLVMKREPIRVKATILPPPT 612

  Fly   790 VEYHSKRFTMVKN-GSWR----------MDGMKFLEPKPKAHKCA------------VLYCDPRS 831
            :.|....|....: |.|.          :||..|   :.|.:|.:            :|...||.
 Worm   613 LVYGDSVFHDEHHIGEWEAVTHDPPRQVLDGAVF---RRKLYKSSEQPLMKRLMGSILLIQSPRQ 674

  Fly   832 GRKMNYTQ---------LNDFGNLIISQGKAVNISLDSDVTYRPFTDDERSLDTIFADLKRSQHD 887
            .|..:|.|         :.|.|..::                  :.|:.:....|..:|:.:|:.
 Worm   675 CRDFDYNQQGYHAIMRAIEDSGQPVL------------------WADENKHSAVIQGELQFNQNQ 721

  Fly   888 LAIVIIPQFRIS---------------------------------------YDTIKQKAELQHGI 913
            ..|.:|.||..:                                       |:.:|..|:.::||
 Worm   722 HGIEVIEQFLQNIKSTIGEYERDGEVIVPIVFAVFQARATVYSGNNNEYNDYNVLKYLADNKYGI 786

  Fly   914 LTQCI------------KQFTVERKCNNQTIGNILLKINSKLNGINHK---IKDDPRLPMMKNTM 963
            .||.|            |...:.|....:.:|.:.........|..||   |..||..|    |:
 Worm   787 HTQGILEKSLGVVGPSPKNCALTRLMVEKVLGKVGTTHRKLERGGAHKTWTIFTDPAKP----TL 847

  Fly   964 YIGADVTHPSPDQREIPSVV------GVAASHDPYGASYNMQYRLQRGALEEIEDMFSITLEHLR 1022
            .:|.||:|||...||..:|:      .|..:.|.....:....|:|...:|.:.|......|.:.
 Worm   848 VLGIDVSHPSTRDRETGNVLQKMSAATVVGNIDLDVTEFRASSRIQDTGVECLIDFSKEIDERIG 912

  Fly  1023 VYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQACDKV--GCKPKICCVIVVKRHHTRFF 1085
            .:.::....|.||:.||||:|:|.|.|...||..||::.|.|:  ..:|.|..::|.|||||:||
 Worm   913 EFIDHTGKRPAHIVVYRDGLSEGDFQKYLFEERVCIEERCLKIDTSFQPSITYIVVTKRHHTQFF 977

  Fly  1086 ---PSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIEN--TGNLDI 1145
               ||....:..  .||.|||:::..:.......||:.:....:|..:||.|.|:.:  ||..|.
 Worm   978 LEDPSQGYESQG--YNVLPGTLIEDAVTTNKYYDFFLSTQIGNEGCFRPTHYYVLHDTWTGKPDS 1040

  Fly  1146 ---DLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVYLTGTNRFLDLKKEY 1199
               .:...||||.|    |...:|:.|||...|||.|.|.:..|.|.|.:..:...|
 Worm  1041 FWPTVTHALTYNFC----RSTTTVALPAPVLYAHLAAKRAKETLDGINTYKSVNNIY 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	210/973 (22%)
		ArgoN	411..543	CDD:293095	26/169 (15%)
		ArgoL1	554..601	CDD:285861	13/62 (21%)
		PAZ	605..719	CDD:239207	34/149 (23%)
		Piwi_ago-like	764..1186	CDD:240015	126/530 (24%)
ergo-1	NP_503362.2	PAZ	421..557	CDD:198017	34/140 (24%)
		Piwi_ago-like	588..1080	CDD:240015	124/522 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1910
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870