Protein Alignment AGO2 and wago-10

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_503177.1
• Gene: wago-10 / 178560
• WormBaseID: WBGene00020707
• Length: 990
• Species: Caenorhabditis elegans
• Alignment Length: 1027
• Identity: 215/1027 - (20%)
• Similarity: 401/1027 - (39%)
• Gaps: 271/1027 - (26%)

  Fly   373 QQPNQTQSQGQYQSRGPPQQQQAAPLPLP--PQPAGSIKRGT---------IGKPGQVGINYLDL 426
            |.|:.|....|...|.|.:.::::.:.:|  .:||..:...|         |.:...|.:|...|
 Worm     6 QNPSPTGFLPQIPFRIPKRTRRSSEVDVPATKRPAPPLTSSTSLPTRDSFSIIETRDVQLNMFAL 70

  Fly   427 DLSKMPS--VAYHYDVKIMPERPK-----------------------------KFYRQAFEQFRV 460
            ::|.||.  ..:|.|..|..:..|                             ||:::..|.|
 Worm    71 NISGMPRKIQRFHVDTLIKGKNGKIFNVNHGVLANSGDINSHNKRLAQHALMQKFHKKRRELF-- 133

  Fly   461 DQLGGAVLAYDGKASCYSVDKLPLNSQNPEVT------------VTDRNGRTLRYT--IEIKETG 511
            .|....:||||...:.|..|.:.|.....|.|            :|.:..|...||  ::|:.:|
 Worm   134 GQHDYHILAYDCANTLYLPDGVYLGRNEEECTFKSDDFSPEQWNITSKLSRKKDYTYVMKIRPSG 198

  Fly   512 DSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNK-AIRVGRSFFK-----MSDPNNRHEL 570
            ......:..:...|      .|...:|||:|.:...:|. ..:.|...|.     :|:|:...|:
 Worm   199 FIYTSGEEASEVAN------RMELTRCVEIVTSQKLNNSDYCQFGNDTFSFRAQPVSEPDATSEI 257

  Fly   571 DDGYEALVGLYQAFMLGDRPFLNVDISHKSFPISMPMI-----EYLER-------------FSLK 617
            ..|:..:..:.:.....:...:.:|.....|..|..::     :|||:             ::.|
 Worm   258 RSGFAKVSRIVEGRNGKNEMLMAIDTKASPFYKSTSVLNFVCGKYLEKRGSSRNDYRGRGDYNRK 322

  Fly   618 AKINNTT-------------NLDY--SRRFLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPA 667
            .....:|             :|:|  :|:.:|..|:|:.|.....::..:...:.||     |..
 Worm   323 KTGGGSTDAPDHQDVAEVERSLEYRENRQQIEEALKGLLVSAAHLKNSTNLIMISRV-----AET 382

  Fly   668 SSET---FEHDG-KKVTIAS-YFHSRNYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQAL--N 725
            :|||   ..::| :::::|. |..:.||.||:|::..:...........|:||..:..||.:  :
 Worm   383 NSETTKFMTNNGEREISVADHYLEAYNYRLKYPKMPLVVSKRFRDECFYPMELLQVAPGQRIKDH 447

  Fly   726 RKDGATQVA-------------NMIKYAATSTNVRKRKIMNLLQYFQHNLDPTISRFGIRIAN-D 776
            :...|.|:|             :::|: ..|.|::          ...||  .:..|||::.: :
 Worm   448 KMSAAVQMAMKGQKSTLPQKHVDLVKH-VLSRNLK----------LDRNL--YMDAFGIKLESAE 499

  Fly   777 FIVVSTRVLSPPQVEYHSKRFTMVKNGS--WRMDGMKFLEPKPKAHKCAVL-------------Y 826
            .:.:.:::|.|||:::..:.: |.|.|:  :|.:| :|::| ...:..|::             :
 Worm   500 LVKLQSKILPPPQIKFKDEVY-MPKMGNPVFRTNG-RFVDP-ADINAVAIVVFDRAIDMRQAENF 561

  Fly   827 CD-------------PRSGRKMNYTQLNDFGNLIISQ------GKAVNISLDSDVTYRPFTDDER 872
            ||             .:|.|.....::|...::.|..      .|.|||
 Worm   562 CDRLSCYCRENGITVKKSSRDWPIREINSEDSVAIKNAMEKWFSKGVNI---------------- 610

  Fly   873 SLDTIFADLKRSQHDLAIVIIPQFRISYDTIKQKAELQHGILT-QCIKQFTVERKCNN---QTIG 933
             |..|..:.|...||:         :.|      .|...|:.| |..|| ||:...::   ||..
 Worm   611 -LVAIAKEKKPDVHDV---------LKY------YEASVGLQTIQVCKQ-TVDMMLSSGGRQTAD 658

  Fly   934 NILLKINSKLNGINHKIK-----------DDPRL---PMMKNTMYIGADVTHPSP----DQR--- 977
            |::.|.|.|..|.|..::           .|..|   .:.:...:||.|::|.:.    |:.
 Worm   659 NVMRKFNLKCGGTNFFVQIPRSVNGRTVCADAHLLNEKLFERVQFIGFDISHGASRTLFDRSTGK 723

  Fly   978 ---EIPSVVGV--AASHDPY--GASY---NMQYRLQRGALEEIEDMFSITLEHLRVYKEYRNAYP 1032
               |: |:|||  :.||..:  |.:|   ..:|:||:     ::::|...::.   |:.:....|
 Worm   724 MDGEV-SIVGVSYSLSHSTHLGGFAYMQTQKEYKLQK-----LDEVFPKCVDS---YRNHTGRLP 779

  Fly  1033 DHIIYYRDGVSDGQFPKIKNEELRCIKQACDKV--GCKPKICCVIVVKRHHTRFFPSGDVTTSNK 1095
            ..|:.||.|..:|.|.::| ||:..|:...:::  ..:|::..:|..:..|.|.||:....:...
 Worm   780 SKIVIYRIGAGEGDFKRVK-EEVDKIRGTFNRIQPDYRPQLVVIIAQRDSHVRVFPAHITGSKAG 843

  Fly  1096 FNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFP 1160
            ..||..||.||..|......:|.:.|...:.||.:|.:|.::.|..|.....:..|||     |.
 Worm   844 QQNVTSGTCVDSVITSLGHQEFILSSQMPLLGTVRPCKYTILTNDPNWTKTEITHLTY-----FR 903

  Fly  1161 RCNRSVSYPAPA-----YLAHLVAARGRVYLTGTNRFLDLKKEYAKRTIVPE 1207
            .....|||..|:     |.|..:|.|||.......||::|  :..:|:::.|
 Worm   904 AFGHQVSYQPPSFPDVLYAAENLAKRGRNNYKVHQRFVNL--QAVERSVIAE 953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	17/85 (20%)
		ArgoL1	554..601	CDD:462567	7/51 (14%)
		PAZ	605..719	CDD:239207	29/151 (19%)
		Piwi_ago-like	764..1186	CDD:240015	114/498 (23%)
wago-10	NP_503177.1	PAZ_argonaute_like	347..439	CDD:239212	22/96 (23%)
		ArgoL2	<478..515	CDD:465136	10/48 (21%)
		Piwi-like	499..932	CDD:239208	110/483 (23%)