Protein Alignment AGO2 and alg-3

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_502217.1
• Gene: alg-3 / 178106
• WormBaseID: WBGene00011910
• Length: 1035
• Species: Caenorhabditis elegans
• Alignment Length: 970
• Identity: 259/970 - (26%)
• Similarity: 411/970 - (42%)
• Gaps: 194/970 - (20%)

  Fly   369 RPPGQQPNQTQSQGQYQSRGPPQQQQA-------APLPLPPQPAGSIK------------RGTIG 414
            ||...|.:...|.|   |..||...|.       :|..|.|.....:.            .||||
 Worm    33 RPASGQASPLSSNG---SLSPPVDDQGSVSYNSDSPRDLSPLLLSELACLNMREVVARPGLGTIG 94

  Fly   415 KPGQVGINYLDLDLS--KMPSVAYHYDV------------------KIMPERPKKFYRQAFEQFR 459
            :...|..|:..:||.  ||..|.||.:|                  |.:.:.|..|:.:
 Worm    95 RKIPVKSNFFAVDLKNPKMVVVQYHVEVHHPGCRKLDKDEMRIIFWKAVSDHPNIFHNK------ 153

  Fly   460 VDQLGGAVLAYDGKASCYSVDKLPLNSQNPEVTV-------TDRNGRTLRYTIEIKETGDSTIDL 517
                  ..|||||....|:|.:|........|.:       .|...|| |..|.|:..|...:::
 Worm   154 ------FALAYDGAHQLYTVARLEFPDDQGSVRLDCEATLPKDNRDRT-RCAISIQNVGPVLLEM 211

  Fly   518 -KSLTTYMNDRIFDKPMRAMQCVEVVL------------------ASPCHNKAIRVGRSFFKMSD 563
             ::.|..:::|:    :..:|.::::.                  .|.|:......|::.
 Worm   212 QRTRTNNLDERV----LTPIQILDIICRQSLTCPLLKNSANFYTWKSSCYRIPTAAGQAL----- 267

  Fly   564 PNNRHELDDGYEALVGLYQAFMLGD--RPFLNVDISHKSF-----PISMPMIEYLERFSLKAKIN 621
                 :|:.|.|...|.:.:..:..  ||.||:|::|.:|     .:...|.:.|...:.|...|
 Worm   268 -----DLEGGKEMWTGFFSSAHIASNYRPLLNIDVAHTAFYKTRITVLQFMCDVLNERTSKPNRN 327

  Fly   622 N--------------------------------------------TTNLD----------YSRRF 632
            |                                            |..:|          :..|.
 Worm   328 NPRGPGAPGGYRGGRGGARGGSYQNFGNRGPPGANVRDDFGGNGLTFTMDTLSRDTQLSSFETRI 392

  Fly   633 LEPFLRG--INVVYTPPQSFQSAPRVYRVNGLSRAPASSETF---EHDGKKV--TIASYFHSRNY 690
            ....:||  |...:.|     :|.|||:||.| :.||....|   :.:|::|  ::|.||..:..
 Worm   393 FGDSIRGMKIRATHRP-----NAIRVYKVNSL-QLPADKLMFQGIDEEGRQVVCSVADYFSEKYG 451

  Fly   691 PLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMNLL 755
            |||:|:|.||:||...::|.||:|.|.|:..|..|:|....|.:.:||.||.....|:.:|..|.
 Worm   452 PLKYPKLPCLHVGPPTRNIFLPMEHCLIDSPQKYNKKMTEKQTSAIIKAAAVDATQREDRIKQLA 516

  Fly   756 QYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEY--HSKRFTMV---KNGSWRMDGMKFLEP 815
            .......||.:..||:.:::..|..|.||:.||.:.:  :::....|   |:|||.||......|
 Worm   517 AQASFGTDPFLKEFGVAVSSQMIETSARVIQPPPIMFGGNNRSINPVVFPKDGSWSMDHQTLYMP 581

  Fly   816 KPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISL---DSDVTYRPFTDDERSLDTI 877
            ........:...|||     :.|.|..|...:..:..|:.::.   ...|.|....:|..:|.|.
 Worm   582 ATCRSYSMIALVDPR-----DQTSLQTFCQSLTMKATAMGMNFPRWPDLVKYGRSKEDVCTLFTE 641

  Fly   878 FADLKRSQHDL--AIVIIPQFRIS--YDTIKQKAELQHGILTQCIKQFTVERKCNNQTIGNILLK 938
            .||..|..:.:  .|:::.|.:.|  |.|:|:::::.|||::||:....|.|. ...|..||:||
 Worm   642 IADEYRVTNTVCDCIIVVLQSKNSDIYMTVKEQSDIVHGIMSQCVLMKNVSRP-TPATCANIILK 705

  Fly   939 INSKLNGINHKIKDDP---RLPMMKNTMYIGADVTHPSPDQ--REIPSVVGVAASHDPYGASYNM 998
            :|.|:.|||.:|..|.   :..:.:.||.:|.|||||:..:  ..:|||..:.|:.|....||..
 Worm   706 LNMKMGGINSRIVADQITNKYLVDQPTMVVGIDVTHPTQAEMRMNMPSVAAIVANVDLLPQSYGA 770

  Fly   999 QYRLQRGALEEIEDMFSITLEHLRVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQACD 1063
            ..::|:...|.:..:.....|.:..:..:....|..||.||||||:|||.::..||::.|:.||.
 Worm   771 NVKVQKKCRESVVYLLDAIRERIITFYRHTKQKPARIIVYRDGVSEGQFSEVLREEIQSIRTACL 835

  Fly  1064 KVG--CKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQ 1126
            .:.  .:|.|..::|.||||.|.|.........|..||.|||.||..||.|....|::.||..:|
 Worm   836 AIAEDFRPPITYIVVQKRHHARIFCKFPNDMVGKAKNVPPGTTVDTGIVSPEGFDFYLCSHYGVQ 900

  Fly  1127 GTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVYL 1186
            ||::|.||:|:.:......|.:|.:||.:||.:.||.||||.|.|.|.|.|||.|.|.::
 Worm   901 GTSRPARYHVLLDECKFTADEIQNITYGMCHTYGRCTRSVSIPTPVYYADLVATRARCHI 960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	16/79 (20%)
		ArgoL1	554..601	CDD:462567	11/48 (23%)
		PAZ	605..719	CDD:239207	41/174 (24%)
		Piwi_ago-like	764..1186	CDD:240015	143/440 (33%)
alg-3	NP_502217.1	ArgoN	152..233	CDD:465134	19/97 (20%)
		ArgoL1	260..304	CDD:462567	12/53 (23%)
		PAZ_argonaute_like	369..479	CDD:239212	36/115 (31%)
		Piwi_ago-like	525..960	CDD:240015	143/440 (33%)