Protein Alignment AGO2 and csr-1

DIOPT Version :9

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_001040938.1
• Gene: csr-1 / 177591
• WormBaseID: WBGene00017641
• Length: 1030
• Species: Caenorhabditis elegans
• Alignment Length: 1130
• Identity: 248/1130 - (21%)
• Similarity: 410/1130 - (36%)
• Gaps: 312/1130 - (27%)

  Fly   220 GR-QGQEGGYQQRPSGQQQGGHQQGRQGQEGGY--QQRPPGQQQGGH--QQGRQGQEGG------ 273
            || :|..||        .:||..:||  ..|||  ..||..:.:..|  .||:...|||
 Worm     7 GRGRGSRGG--------SRGGSGRGR--GRGGYGDSYRPDLETRETHVTYQGKVKYEGGDRHDFN 61

  Fly   274 YQQRPPGQQQGGHEQGRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPSGQQQ------GGH 332
            |::.|.|..:|.|..|::|..|         .:|..:.||    |||.:|...::.      ||:
 Worm    62 YEKTPTGSYRGSHRDGQEGSRG---------NRGSFRGGR----GGYDRRRDDEESKAENRFGGY 113

  Fly   333 QQGRQGQEGGYQQRPSGQQQGGHQQGRQGQ--------EGGYQQRPPGQQPNQTQSQGQYQSRGP 389
            .:|..|  |.|:.|..|..:||..|.....        |...:.:..|...:..|.|..
 Worm   114 NRGANG--GNYRGRTGGSGRGGSTQTTTVDPKYNGLILENSAEPKLKGLNSDMNQKQNP------ 170

  Fly   390 PQQQQAAPLPLPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPERPKKFY--- 451
                                        ::.:|...|:||:.....:...:|::..:..|.|
 Worm   171 ----------------------------RLALNIFGLELSERTIFRHVVQMKLIDRQHNKEYILT 207

  Fly   452 --------RQAFEQ---------------FRVDQLGGAVLAYDGKASCYSVDKLPLNSQNPEVTV 493
                    .:|.:|               .:..|......||||..|.::::.:.|
 Worm   208 TMSARGRGNRATKQKDNFILLDILLKQWAAKKGQQNLPAFAYDGAQSLFTLEGISL--------- 263

  Fly   494 TDRNGRTLRYTIEIKETGDSTIDLKSLTTYMNDRI--------------FDKPM----------- 533
                      .::||:  :..:::..|:.::.|.|              .:||.
 Worm   264 ----------MVDIKK--EDALEIPELSNFLKDSISFLSGDLEISCEPDLEKPSFVQTELNEWSD 316

  Fly   534 -RAMQCVEVVLASPCHNKAIRVGRSFFKMSDPNNRHELDDGYE--------ALVGLYQAFML--- 586
             |....:::|.:    ..|||..|   .:|.....:......|        |..|:::...:
 Worm   317 PRFYAYLDIVTS----QSAIRSER---YLSQSKGLYVHTQSLEELRVKWAVAAKGIHKGCRIVGA 374

  Fly   587 -GDRPFLNVDISHKSFPISMPMIEYLE-----RFSLKAKINNTTNLDYSRRFLEPFLRGINVVYT 645
             |..|.|.:|.....:..|:|:.:.|:     .|.....:|....|..:.:.|...|: .|..|.
 Worm   375 NGPLPILELDPQSTQYYASIPLSQMLQYAFPRDFPPNRIVNPNMKLQRAVKLLLKDLK-CNPYYD 438

  Fly   646 PPQSFQSAPRVYRVNGLS------RAPASSETFEHDGKKVTIASYFHSRNYP-LKFPQLHCLNVG 703
            ..|       ::..|.::      .||...|               ..:.|| ||||.|..:..|
 Worm   439 DKQ-------IWATNTITVSDVDYNAPKDPE---------------FRQKYPNLKFPMLPAVQCG 481

  Fly   704 SSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYA--ATSTNVRKRKIMNLLQYFQHNLDPTI 766
            :.....|:|:|...:...|:::|:     |....:..  |.:.|.|...:......|..| |..:
 Worm   482 TGPHKRLMPLEYLKVLPYQSIDRR-----VLEEFELTPRANAPNERWSTLQKHYDQFGFN-DQVM 540

  Fly   767 SRFGIRIAND-FIVVS----TRVLSPPQVEYHSKRFTMVKNGSWRMDGMKFLEPKPKAHKCAVLY 826
            ..||::|.|| |..||    .|||: |.|.|........:...|:....||:.|....|...||.
 Worm   541 KDFGVQICNDPFNNVSEIDGERVLA-PSVAYADPVHVDDEKRDWKAQDKKFVTPATIDHLMFVLV 604

  Fly   827 C------------------------------------DPRSGRKMNYTQLND-FGNLIISQGKAV 854
            .                                    |..:|.:.:...|.. |.||:.....
 Worm   605 AGYTRTWDADCDATKFVAKAFMQRCKDKGMHIGSYSMDQHNGERGSENFLTSVFKNLVTHPNY-- 667

  Fly   855 NISLDSDVTYRPF----TDDERSLDTIFADLKR-----SQHDLAIVIIPQFRISYDTIKQKAELQ 910
                 .|.::.||    :||..::.......:|     :||    |::...:...|.|::|:  |
 Worm   668 -----RDSSFTPFVLFISDDVPNIHECLKFEERMSDIPTQH----VLLKNVKKMRDNIEKKS--Q 721

  Fly   911 HGILTQCIKQFTVERKCNNQTIGNILLKINSKLNGINHKIKDDPRLPMMKN---TMYIGADVTHP 972
            .|            |:..:.|:.||::|.|.|..|:|: ..|.||.....|   |..||.||.||
 Worm   722 GG------------RRAYDLTLDNIVMKANIKCGGLNY-TADIPRDLACWNEVSTFVIGMDVAHP 773

  Fly   973 SPD-QRE-IPSVVGVA--ASHDPYGASYNMQYRLQRGALEEIEDMFSITLEHLRVYKEYRNAYPD 1033
            ..: .|| .||.||::  ::.:||....:..|...|....:.|.:...|.:.:|.:.|.| .:|.
 Worm   774 DRNAAREGNPSTVGLSCNSAENPYSFIGDFLYTDPRREAIQDEILRKFTDQSVRNFAEIR-GFPK 837

  Fly  1034 HIIYYRDGVSDG-QFPKIKNEEL--RCIKQACDKVG---CKPKICCVIVVKRHHTRFFPSGDVTT 1092
            .:|.:|||||.| :...:|..|:  :.||.|...:|   ..||:..::|.|||||||:..|....
 Worm   838 KVIIFRDGVSFGEETAALKEVEIIEQTIKTAAKSMGHSDYAPKVLAIVVKKRHHTRFYAKGGHHG 902

  Fly  1093 SNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCH 1157
            :...|.: |.|.|...|....:.|.|:.:.:.:|||||...:.||.:...:..:.:.::...:|.
 Worm   903 NMPINPL-PDTSVGGDIAEYGKRQIFIQAFRPVQGTAKVPSFLVIRDDEEVSDEHVAKMVCAVCS 966

  Fly  1158 MFPRCNRSVSYPAPAYLAHLVAARG 1182
            :....|...|.|.|.|:||.:|.||
 Worm   967 LHQLVNSPTSIPTPVYVAHELAKRG 991

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	195/910 (21%)
		ArgoN	411..543	CDD:293095	24/183 (13%)
		ArgoL1	554..601	CDD:285861	9/58 (16%)
		PAZ	605..719	CDD:239207	25/125 (20%)
		Piwi_ago-like	764..1186	CDD:240015	126/483 (26%)
csr-1	NP_001040938.1	PAZ	399..521	CDD:198017	28/149 (19%)
		Piwi-like	555..993	CDD:239208	120/466 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010