DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and alg-2

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_871992.1	Gene:	alg-2 / 173468	WormBaseID:	WBGene00000106	Length:	910	Species:	Caenorhabditis elegans

Alignment Length:	939	Identity:	275/939 - (29%)
Similarity:	431/939 - (45%)	Gaps:	138/939 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 GGHQQGRQGQEGGYQQRPPGQQPNQTQSQGQYQSRGPPQQQQAAPLPLPPQPAGSIKRGTIGKPG 417
            ||.:.....|.||......|.:|:   :..|:|              .|.:|    ..|..|:..
Worm    34 GGAETSSSSQLGGSAHGAIGTKPD---AGVQFQ--------------CPVRP----NHGVEGRSI 77

  Fly   418 QVGINYLDLDLSKMP-SVAYHYDVKIMPER-PKKFYRQAFEQFRVDQLGGAVLA----------- 469
            .:..|:..:   ::| ....||.:.:.|:: |::..|:..         |.:::
Worm    78 LLRANHFAV---RIPGGSVQHYQIDVFPDKCPRRVNREVI---------GCLISSFSKYFTNIRP 130

  Fly   470 -YDGKASCYSVDKLPLNSQ--NPEVTVTDRNGRTLRYTIEIKETGDSTIDLKSLTTYMNDRIFDK 531
             ||||.:.|:.:.||:.::  |.|||:...:....::::.:|..|.  :.|.:|...|..|:...
Worm   131 VYDGKRNMYTREPLPIGTEPMNFEVTLPGDSAVERKFSVTMKWIGQ--VCLSALDDAMEGRVRQV 193

  Fly   532 PMRAMQCVEVVLASPCHNKAIRVGRSFFK----MSDPNNRHE---LDDGYEALVGLYQAFMLGDR 589
            |..|:|.::|:|......|...||||||.    |......|:   |..|.|...|.:|:.    |
Worm   194 PHEAVQSIDVILRHLPSLKYTPVGRSFFTPPGVMKPGMQMHQESKLGGGREVWFGFHQSV----R 254

  Fly   590 P-----FLNVDISHKSFPISMPMIEY--------LERFSLKAKINNTTNLDYSRRFLEPFLRGIN 641
            |     .||:|:|..:|..:||:||:        ::..:.:..:::...:.:::.     :||:.
Worm   255 PSQWKMMLNIDVSATAFYRAMPVIEFVAEVLELPVQALAERRALSDAQRVKFTKE-----IRGLK 314

  Fly   642 VVYTPPQSFQSAPRVYRVNGLSRAPASSETFE---HDGKKV--TIASYFHSR-NYPLKFPQLHCL 700
            :..|   ...:..|.|||..::|.||.::||.   ..|:.:  |:|.||..: ...||:|.|.||
Worm   315 IEIT---HCGAVRRKYRVCNVTRRPAQTQTFPLQLETGQTIECTVAKYFFDKYRIQLKYPHLPCL 376

  Fly   701 NVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMNLLQYFQHNLDPT 765
            .||...|...||.|:|.|..||...:|....|.:.|||..|.|...|:|:|..|:...:.:.||.
Worm   377 QVGQEQKHTYLPPEVCDIVPGQRCLKKLTDVQTSTMIKATARSAPEREREICKLVSKAELSADPF 441

  Fly   766 ISRFGIRIANDFIVVSTRVLSPPQVEY---HSKRFTMVKNGSWRMDGMKF---LEPKPKAHKCAV 824
            ...|||.|......|..||||.|::.|   |.....:...|.|.|.|.:|   :|.:..|..|..
Worm   442 AHEFGITINPAMTEVKGRVLSAPKLLYGGRHRATTALPNQGVWDMRGKQFHTGMEVRTWAIACFA 506

  Fly   825 LYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISLDSDVTYRP----FTDDERSLDTIFADLKR-- 883
                     :.::.:.||. .:..:|.:.::......:...|    :......::.:|..||:
Worm   507 ---------QQSHVKENDL-RMFTTQLQRISTDAGMPIIGTPMFCKYASGVEQVEPMFKYLKQTY 561

  Fly   884 SQHDLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTVERKCNNQTIGNILLKINSKLNGINH 948
            |...|.:|::|.....|..:|:..:...||.|||::.....| ...||:.|:.||:|.||.|:|.
Worm   562 SAIQLIVVVLPGKTPIYAEVKRVGDTVLGIATQCVQAKNAIR-TTPQTLSNLCLKMNVKLGGVNS 625

  Fly   949 KIKDDPRLPMMKN--TMYIGADVTHPSPDQREIPSVVGVAASHDPYGASYNMQYRLQRGALEEIE 1011
            .:..:.| |.:.|  .:::|.|:|||:......||:..|..|.|.:.:.|....|:|:...|.|.
Worm   626 ILLPNVR-PRIFNEPVIFLGCDITHPAAGDTRKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIIT 689

  Fly  1012 DMFSITLEHLRVYKEYRNA--YPDHIIYYRDGVSDGQFPKIKNEELRCIKQACDKV--GCKPKIC 1072
            |:..:..|.|..:  |||.  .|..|:.||||||:||...:...|||.|::||..:  |.:|.|.
Worm   690 DLTYMVRELLVQF--YRNTRFKPARIVVYRDGVSEGQLFNVLQYELRAIREACVMLESGYQPGIT 752

  Fly  1073 CVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVI 1137
            .:.|.||||||.|.:.......|..|:.|||.||..|.||.|..||:.||..||||::|:.|:|:
Worm   753 FIAVQKRHHTRLFAADKADQVGKAFNIPPGTTVDVGITHPTEFDFFLCSHAGIQGTSRPSHYHVL 817

  Fly  1138 ENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVYL--------------TG 1188
            .:..:|..|.||||||.:||.:.||.||||.|||||.|||||.|.|.:|              :|
Worm   818 WDDNDLTADELQQLTYQMCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDRDHGSGEEGSQPSG 882

  Fly  1189 TNRFLDLKKEYAKRTIV-PEFMKKNPMYF 1216
            |:.........||...| |:  ..|.|||
Worm   883 TSSEDTTLSSMAKAVQVHPD--SNNVMYF 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	250/828 (30%)
		ArgoN	411..543	CDD:293095	31/147 (21%)
		ArgoL1	554..601	CDD:285861	19/58 (33%)
		PAZ	605..719	CDD:239207	34/127 (27%)
		Piwi_ago-like	764..1186	CDD:240015	151/439 (34%)
alg-2	NP_871992.1	PLN03202	67..859	CDD:215631	250/835 (30%)
		ArgoN	67..205	CDD:293095	32/155 (21%)
		ArgoL1	216..273	CDD:285861	20/60 (33%)
		PAZ_argonaute_like	274..395	CDD:239212	34/128 (27%)
		Piwi_ago-like	440..866	CDD:240015	151/439 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1910
OMA	1	1.010	-	-		QHG58336
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.980