DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and alg-5

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_001370006.1	Gene:	alg-5 / 172861	WormBaseID:	WBGene00011945	Length:	905	Species:	Caenorhabditis elegans

Alignment Length:	867	Identity:	217/867 - (25%)
Similarity:	383/867 - (44%)	Gaps:	93/867 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 PQQQQAAPLPLPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPERPKKFYRQA 454
            |.::...|..|..:|..|    |.|:...:..|:..:..:  .|:.:.|.::..|:.|.|...:.
Worm    58 PIEENREPFKLIGKPLPS----TTGRFLSLLANHFQITCN--GSIIHQYYIRFDPDIPSKKLNRT 116

  Fly   455 FEQFRVDQLGGAV---LAYDGKASCYSVDKLPLNSQNPEV-----TVTDRNGRTLRYTIEIKETG 511
            ..:...:|..|.:   |.:||..:.||.:.:.:...|..|     .|..:....| :.:.:....
Worm   117 ILRTLQEQNPGLIECPLVFDGIHTVYSTELINVKEVNNSVINVAGVVNTKESPNL-FKLYLTHVD 180

  Fly   512 DSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAIRVGRSFFKMS-----DPNN----- 566
            ...:|.|.:|...:.   ::.:|.|..::.|...........|.:|||.::     :|::
Worm   181 SFLLDTKIITGNQDQ---NQKLRMMHAIDTVFRQTSTGNFHAVLQSFFSIAQNSAIEPSHGLGWG 242

  Fly   567 RHELDDGYEALVGLYQAFM-LGDRPFLNVDISHKSFPISMPMIEYLERFSLKAKINNTTN----L 626
            ...|..|.|...|.||..: ..|...:|:|::..:|...:.::|:|... |:..:...|:    .
Worm   243 TVNLGVGREVCYGFYQNVVETFDTLTMNLDVATTTFYRPVALVEFLAEI-LEVPLATVTDGRSLS 306

  Fly   627 DYSRRFLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETF-------EHDGKKVTIASY 684
            |..::.....:.|:.|    .....|.||.:||...:..|..:.:|       ..|.|.:::..|
Worm   307 DVQKKKFNREVAGLKV----ETRHCSCPRRFRVARCTWKPTENISFHLSETAGNQDSKPLSLVEY 367

  Fly   685 FHSR-NYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRK 748
            :..| |..|.:..|.|:.||.: :..:||:|||.:..||...:|....|:||:|:  |||.|..:
Worm   368 YKRRYNIDLTYKHLPCIEVGRT-RECILPLELCYVVSGQRCIKKLNEQQIANLIR--ATSRNATE 429

  Fly   749 RK--IMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEYHS---KR---FTMVKNGSW 805
            |:  :|:|....:.:.|....:||:::....:.:..|||..|::.|.|   ||   .|:..||:|
Worm   430 RQNAVMSLQNRLKMDNDVNAVKFGLKVEAQLLKIEGRVLPVPRLLYRSPNLKRQECVTVPNNGTW 494

  Fly   806 RMDGMKFLEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISLDSDVTYRPFTDD 870
            .|.|..|...........|.:..|..   :....:..|...:::....:.:         ||.::
Worm   495 DMRGKNFYSGIQIREWAIVCFASPEI---IGEASMRSFVRNLVNVASEIGM---------PFLEE 547

  Fly   871 ERSLDTIFAD--LKRSQH-------DLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTVERK 926
            .|.......|  :|..:|       .|.:.|:|...:.|..:|:|.||. |:.|||::...|. |
Worm   548 HRFCRYAEPDQTVKLLEHLNEQYNLQLVLCIVPGKSVVYGELKRKGELL-GLTTQCVRSQNVS-K 610

  Fly   927 CNNQTIGNILLKINSKLNGINHKIKDDPRLPMMKNTMYIGADVTH----PSPDQREI-----PSV 982
            .:..|:.|:.:||||||.|||..:...|:....:..::||..:|.    .|.|....     .|:
Worm   611 ASPHTLSNLCMKINSKLGGINVILSSPPQSLNSEPVLFIGCHLTRSSLASSSDSTSSIAHCDSSI 675

  Fly   983 VGVAASHDPYGASYNMQYRLQRGALEEIEDMFSITLEHLRVYKEYRNAYPDHIIYYRDGVSDGQF 1047
            ..:..|.|.:...::..:|.|......|.||..:|.|.:..:::.....|..||.||.|::|...
Worm   676 ACLVGSMDGHPTQFSPIFRTQPRHQRTIVDMCEMTREAIINFRKSTGFKPHKIIIYRAGIADVTV 740

  Fly  1048 PKIKNEELRCIKQACDKV--GCKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIV 1110
            .:|...|||.::.||..:  |.:|.|..:.:...||||.|.:.:........||..||:|:..|.
Worm   741 DEIMQTELRAVRDACAMIEYGFQPGITFIGLDVTHHTRLFAANEKDRVGNSQNVPAGTLVETGIT 805

  Fly  1111 HPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLA 1175
            ..|..:|::|||..||||::||:|.|:.:..::....:.::||.|||...||.||||.|:|.|.|
Worm   806 VNNLFEFYLVSHAGIQGTSRPTKYVVMWDDNSIPSADIHEMTYQLCHTQSRCTRSVSIPSPVYYA 870

  Fly  1176 HLVAARGRVYLTGTNRFLDLKK 1197
            .|||.|.::.:...|  .|:::
Worm   871 KLVAQRAKILMADEN--FDMER 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	208/827 (25%)
		ArgoN	411..543	CDD:293095	24/139 (17%)
		ArgoL1	554..601	CDD:285861	14/57 (25%)
		PAZ	605..719	CDD:239207	29/125 (23%)
		Piwi_ago-like	764..1186	CDD:240015	126/447 (28%)
alg-5	NP_001370006.1	ArgoL1	219..280	CDD:400854	15/60 (25%)
		PAZ	303..418	CDD:396648	29/119 (24%)
		Piwi_ago-like	448..881	CDD:240015	126/446 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1910
OMA	1	1.010	-	-		QHG58336
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.880