Protein Alignment AGO2 and vsra-1

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_001417601.1
• Gene: vsra-1 / 172816
• WormBaseID: WBGene00007297
• Length: 946
• Species: Caenorhabditis elegans
• Alignment Length: 939
• Identity: 225/939 - (23%)
• Similarity: 364/939 - (38%)
• Gaps: 228/939 - (24%)

  Fly   386 SRGPPQQ---QQAAPLPLPP------QPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVK 441
            |..||..   ::..|||:|.      :|...::.....||.:|..|..:|:|.  |:..:.|||.
 Worm    47 SSNPPTPSAIEKPVPLPVPSKPLFEYEPPAQLEALAKNKPVKVTTNSYELELK--PTPVFRYDVS 109

  Fly   442 IMPERPKKF------------------YRQA--FEQFRV----DQLGGAVLAYDGKASCYSVDK- 481
            ::    |.|                  .|||  .|..:|    :.||...:.|||.|..::..|
 Worm   110 VL----KSFDDSTRDPIELAGSKGGDRQRQADLTEIVKVALTLEGLGNLNIFYDGAAMLFTTQKF 170

  Fly   482 -----------LPLNSQNPEVTVT---DRNGRT---LRYTIEI--KETGDSTIDLKSLTTYMNDR 527
                       :|:.|.:|:::.:   .:.||.   ...:||:  |::..:||||      :|:|
 Worm   171 ETKTEKQQAIFMPIPSDHPKLSTSLKESQFGRASGKFHVSIELNSKQSELNTIDL------LNER 229

  Fly   528 IFDKPMRAMQCVEVVLASPCHNKAIRV---GRSFFKMSDPNNRHEL-DDGYEALVGLYQAFML-- 586
            :........|..::.|::........:   |...|  ...|.|..: .||.|.:.|:..:..:
 Worm   230 LDSAACPVTQMAQIALSAEAKQNGFIILDGGHELF--DQKNTRRTIGKDGVEDMDGVAASIKMAQ 292

  Fly   587 GDR----PFLNVDISHKSFPISMPMIEYLE-------RFSLKAKINNTTNLDYSRRFLEPFLRGI 640
            |::    ..|.:|...|.|..:.|:.:.::       |..||....:||   ||.:.:  |:.||
 Worm   293 GNKKTGSAHLVMDYKKKQFFKTGPLKDLIKGINPNQLRSYLKGLRVHTT---YSHQSI--FIDGI 352

  Fly   641 NVV---------YTP-----------PQSF--QSAPRVYRVNGLSRAPASSETFEHDGKKVTIAS 683
            :.|         .||           |:||  .|.|.| :||..::         .:|:::..:
 Worm   353 SNVPIGEIKLPDGTPLLDDCARVSGKPKSFFDASKPAV-QVNQYNK---------REGRRMVYS- 406

  Fly   684 YFHSRNYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRK 748
                                       .|||...::..|.|.:..|  :....||.......:||
 Worm   407 ---------------------------FPIENLLVKPNQKLTQNHG--EPPRSIKPELRFDLIRK 442

  Fly   749 ----RKIMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEYHSKRFT---MVKNGSWR 806
                .|:::..|        |:...||.|..:.|||....:..|.:.|....||   ::...||.
 Worm   443 VGESAKLLSPNQ--------TLKSIGIAINPEPIVVEAMTVPKPTILYKDGAFTSPDLLNRTSWD 499

  Fly   807 MDGMK-------FLEPKPKAHKCAVLYCDPRSGRKMNYTQLN------DFGNLIISQGKAVNISL 858
            :....       |:||. |.:|..:||      ...:|:|.:      :..:::..:.|.|.:::
 Worm   500 VQARNHQSLKGGFVEPM-KINKILILY------NSQSYSQASPKEAVVELQSILSKKAKDVGMTI 557

  Fly   859 DS-DVTYRPFTDDERSLDTIFADLKRSQHDLAIVIIPQFRI--SYDTIKQKAELQHGILTQCIKQ 920
            .. ||......|...:::.....||.||.. .|||......  ::.|:|.:..|...|..|....
 Worm   558 GQIDVEDLNDPDIIGAIENKMTILKTSQVK-PIVIYADHTSEGTHSTLKLQERLCEVITQQVALD 621

  Fly   921 FTVERKCNNQTIGNILLKINSKLNGINHKIKDDPRLPMM----KNTMYIGADVTHPSP---DQRE 978
            .:::|.....|..|:|:|:|.|..|:|||::.|..:..:    .||:.|..||.|.|.   .:.|
 Worm   622 KSLKRTPGKVTANNLLMKLNLKYGGVNHKVRVDNSISHLWGDTSNTLIISYDVCHSSGKVYKKDE 686

  Fly   979 I---PSVVGVA--ASHDPYGASYNMQYRLQRGALEEIEDMFSITLEH---------LRVYKEYRN 1029
            |   ||.||..  .:..|.....:..|:|.|.  |:::       ||         |..|...|.
 Worm   687 ICDEPSCVGFGFNGTACPEAFIGDFHYQLPRH--EQVD-------EHLLKLRARFMLNHYITSRK 742

  Fly  1030 AYPDHIIYYRDGVSDGQFPKIKNEELRCIKQAC-----DKVGCKPKICCVIVVKRHHTRFFPSGD 1089
            .||..::..|||||:||...::|||.:.|||:.     :|....|....::|.|||..|.... |
 Worm   743 KYPQQVVILRDGVSEGQHKMVRNEEFQAIKQSIMNVFNEKKAKAPSFALLVVTKRHANRLLIK-D 806

  Fly  1090 VTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDI-DLLQQLTY 1153
            ...|. :.||.|.|.:|:|||.....:...|||..:.|||:|...|.:.|.|.... |.|.|...
 Worm   807 QNVSG-YTNVPPLTAIDQTIVKKQGNEVIFVSHCPLNGTAQPIVINTLVNDGIFKTNDQLVQFIT 870

  Fly  1154 NLCHMFPRCNRSVSYPAPAYLAHLVAARG 1182
            .||....:....||.|...|.|...|.||
 Worm   871 ALCCAHQKSTNIVSLPESIYAADEYAKRG 899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	19/91 (21%)
		ArgoL1	554..601	CDD:462567	12/56 (21%)
		PAZ	605..719	CDD:239207	26/142 (18%)
		Piwi_ago-like	764..1186	CDD:240015	129/465 (28%)
vsra-1	NP_001417601.1	PRK12323	<13..231	CDD:481241	46/195 (24%)
		Piwi	589..904	CDD:214930	98/322 (30%)