DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and C04F12.1

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_492573.1	Gene:	C04F12.1 / 172816	WormBaseID:	WBGene00007297	Length:	944	Species:	Caenorhabditis elegans

Alignment Length:	934	Identity:	224/934 - (23%)
Similarity:	358/934 - (38%)	Gaps:	220/934 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   386 SRGPPQQ---QQAAPLPLPP------QPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVK 441
            |..||..   ::..|||:|.      :|...::.....||.:|..|..:|:|.  |:..:.|||.
Worm    47 SSNPPTPSAIEKPVPLPVPSKPLFEYEPPAQLEALAKNKPVKVTTNSYELELK--PTPVFRYDVS 109

  Fly   442 IMPERPKKF------------------YRQA--FEQFRV----DQLGGAVLAYDGKASCYSVDK- 481
            ::    |.|                  .|||  .|..:|    :.||...:.|||.|..::..|
Worm   110 VL----KSFDDSTRDPIELAGSKGGDRQRQADLTEIVKVALTLEGLGNLNIFYDGAAMLFTTQKF 170

  Fly   482 -----------LPLNSQNPEVTVT---DRNGRT---LRYTIEI--KETGDSTIDLKSLTTYMNDR 527
                       :|:.|.:|:::.:   .:.||.   ...:||:  |::..:||||      :|:|
Worm   171 ETKTEKQQAIFMPIPSDHPKLSTSLKESQFGRASGKFHVSIELNSKQSELNTIDL------LNER 229

  Fly   528 IFDKPMRAMQCVEVVLASPCHNKAIRV---GRSFFKMSDPNNRHEL-DDGYEALVGLYQAFML-- 586
            :........|..::.|::........:   |...|  ...|.|..: .||.|.:.|:..:..:
Worm   230 LDSAACPVTQMAQIALSAEAKQNGFIILDGGHELF--DQKNTRRTIGKDGVEDMDGVAASIKMAQ 292

  Fly   587 GDR----PFLNVDISHKSFPISMPMIEYLERFSLKAKINNTTNLDYSRRFLEPFLRGINVVYTPP 647
            |::    ..|.:|...|.|..:.|:.:.::      .||...        |..:|:|:.|..|
Worm   293 GNKKTGSAHLVMDYKKKQFFKTGPLKDLIK------GINPNQ--------LRSYLKGLRVHTT-- 341

  Fly   648 QSFQSAPRVYRVNGLSRAPASSETFEHDGKKVTIASYFHSRNYPLKFPQL-HCLNVGSSIKSIL- 710
            .|.||   :: ::|:|..|. .|....||.                 |.| .|..|....||..
Worm   342 YSHQS---IF-IDGISNVPI-GEIKLPDGT-----------------PLLDDCARVSGKPKSFFD 384

  Fly   711 ----------------------LPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRK----R 749
                                  .|||...::..|.|.:..|  :....||.......:||    .
Worm   385 ASKPAVQVNQYNKREGRRMVYSFPIENLLVKPNQKLTQNHG--EPPRSIKPELRFDLIRKVGESA 447

  Fly   750 KIMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEYHSKRFT---MVKNGSWRMDGMK 811
            |:::..|        |:...||.|..:.|||....:..|.:.|....||   ::...||.:....
Worm   448 KLLSPNQ--------TLKSIGIAINPEPIVVEAMTVPKPTILYKDGAFTSPDLLNRTSWDVQARN 504

  Fly   812 -------FLEPKPKAHKCAVLYCDPRSGRKMNYTQLN------DFGNLIISQGKAVNISLDS-DV 862
                   |:||. |.:|..:||      ...:|:|.:      :..:::..:.|.|.:::.. ||
Worm   505 HQSLKGGFVEPM-KINKILILY------NSQSYSQASPKEAVVELQSILSKKAKDVGMTIGQIDV 562

  Fly   863 TYRPFTDDERSLDTIFADLKRSQHDLAIVIIPQFRI--SYDTIKQKAELQHGILTQCIKQFTVER 925
            ......|...:::.....||.||.. .|||......  ::.|:|.:..|...|..|.....:::|
Worm   563 EDLNDPDIIGAIENKMTILKTSQVK-PIVIYADHTSEGTHSTLKLQERLCEVITQQVALDKSLKR 626

  Fly   926 KCNNQTIGNILLKINSKLNGINHKIKDDPRLPMM----KNTMYIGADVTHPSP---DQREI---P 980
            .....|..|:|:|:|.|..|:|||::.|..:..:    .||:.|..||.|.|.   .:.||   |
Worm   627 TPGKVTANNLLMKLNLKYGGVNHKVRVDNSISHLWGDTSNTLIISYDVCHSSGKVYKKDEICDEP 691

  Fly   981 SVVGVA--ASHDPYGASYNMQYRLQRGALEEIEDMFSITLEH---------LRVYKEYRNAYPDH 1034
            |.||..  .:..|.....:..|:|.|.  |:::       ||         |..|...|..||..
Worm   692 SCVGFGFNGTACPEAFIGDFHYQLPRH--EQVD-------EHLLKLRARFMLNHYITSRKKYPQQ 747

  Fly  1035 IIYYRDGVSDGQFPKIKNEELRCIKQAC-----DKVGCKPKICCVIVVKRHHTRFFPSGDVTTSN 1094
            ::..|||||:||...::|||.:.|||:.     :|....|....::|.|||..|..    :...|
Worm   748 VVILRDGVSEGQHKMVRNEEFQAIKQSIMNVFNEKKAKAPSFALLVVTKRHANRLL----IKDQN 808

  Fly  1095 KFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDI-DLLQQLTYNLCHM 1158
            .:.||.|.|.:|:|||.....:...|||..:.|||:|...|.:.|.|.... |.|.|....||..
Worm   809 GYTNVPPLTAIDQTIVKKQGNEVIFVSHCPLNGTAQPIVINTLVNDGIFKTNDQLVQFITALCCA 873

  Fly  1159 FPRCNRSVSYPAPAYLAHLVAARG 1182
            ..:....||.|...|.|...|.||
Worm   874 HQKSTNIVSLPESIYAADEYAKRG 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	213/896 (24%)
		ArgoN	411..543	CDD:293095	39/175 (22%)
		ArgoL1	554..601	CDD:285861	12/56 (21%)
		PAZ	605..719	CDD:239207	26/137 (19%)
		Piwi_ago-like	764..1186	CDD:240015	128/465 (28%)
C04F12.1	NP_492573.1	PRK14971	<13..231	CDD:237874	46/195 (24%)
C04F12.1	NP_492573.1	Piwi	589..902	CDD:214930	97/322 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810