Protein Alignment AGO2 and wago-1

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_492045.1
• Gene: wago-1 / 172463
• WormBaseID: WBGene00011061
• Length: 945
• Species: Caenorhabditis elegans
• Alignment Length: 955
• Identity: 215/955 - (22%)
• Similarity: 364/955 - (38%)
• Gaps: 198/955 - (20%)

  Fly   370 PPGQQPNQTQSQGQYQSRGPPQQQQAAP----LPLPPQPAGS------------IKR-------- 410
            ||...|..           ||.....||    .|:||.||.:            |||
 Worm     5 PPQPHPPM-----------PPMPPVTAPPGAMTPMPPVPADAQKLHQSTGNDACIKRLQQLNVED 58

  Fly   411 -----------GTIGKPGQVGINYLDLDLSKMPSV---AYHYDVKIMPERPKKFYRQAFEQFRVD 461
                       |.:|:|..:..|...::::|..:|   ..|....:...:...|.::..|.|.|.
 Worm    59 GAKMYMKPTEPGKMGRPVDIQTNVFGIEVTKETTVHRFMVHAKADLTSTKEVTFTKKGKEDFVVQ 123

  Fly   462 ----------------------QLGGAVLAYDGKASCYSVDKL--PLNSQNPEVTVTDRNG---- 498
                                  ...|..:.|||:::.|:...|  .|::...:..|...||
 Worm   124 DRRDKCCNIFFLAVEKNPEFFKMKDGNQIVYDGQSTLYTTVNLFSELDANGTKSKVFQINGADTG 188

  Fly   499 ----RTLR-YTIEIKETGDSTIDLKSLTTYMNDRIFDKPMRA-----MQCVEVVLASPCHNKAIR 553
                :||. .::||....|::|.|.|  ..:..|..|:.:..     .|.:|:.|...|..:..|
 Worm   189 NDDLKTLPCISLEIYAPRDNSITLSS--ENLGKRTADQNIEVNNREYTQFLELALNQHCVRETNR 251

  Fly   554 V-----GRSFFKMS-----DPNNRHELDDGYEALVGLYQA--FMLG------DRPFLNVDISHKS 600
            .     |:.:|..:     |..:..::.||.:...||.:.  |:.|      :.|.|.:|....:
 Worm   252 FGCFEHGKVYFLNATEEGFDQRDCVDVGDGKQLYPGLKKTIQFIEGPYGRGQNNPSLVIDGMKAA 316

  Fly   601 FPISMPMIEYLERFSLKAKINNTTNLDYSRRFLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRA 665
            |.....:|:.|...:.:...|...|:  :|......::|::...|    :.:..|..|:.|:...
 Worm   317 FHKEQTVIQKLFDITGQDPSNGLNNM--TREKAAAVIKGLDCYST----YTNRKRHLRIEGIFHE 375

  Fly   666 PASSETFE-HDGKKVTIASYFHSR-NYPLKFPQLH---CLNVGSSIKSILLPIELCSIEEGQALN 725
            .|:...|| .|||..:||.|:..: ...|::|..:   |.:.|:   :...|.||.::...|.:.
 Worm   376 SATKTRFELPDGKTCSIAEYYADKYKISLQYPNANLVVCKDRGN---NNYFPAELMTVSRNQRVT 437

  Fly   726 -RKDGATQVANMIKYAATSTNVRKRKIM---NLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLS 786
             .:....|.....|..|...:||:|.|:   |.:.....|  ..:...||::.::.::|..|.|.
 Worm   438 IPQQTGNQSQKTTKECAVLPDVRQRMIITGKNAVNITLEN--ELLVALGIKVYSEPLMVQARELD 500

  Fly   787 PPQVEYHSKRFTMVKNGSWRMDGMKFLEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQG 851
            ..::.|  :|..|...|.||.....|::|.......|. |.....|.:.:...:|....:.|...
 Worm   501 GKELVY--QRSVMSDMGKWRAPPGWFVKPATVPDLWAA-YAVGNPGCRFSIGDVNQLVGMFIDSC 562

  Fly   852 KAVNISLDSDVTYRPFTDDERSLDTIFADLKR---SQHDLAIVI----IPQFRISYDTIKQKAEL 909
            |...:     |...|......|.:.|...|::   |:....::|    |......|..::|:
 Worm   563 KKKGM-----VIKPPCETGLYSTEKIMTQLEKVAASKCKYVLMITDDAIVHLHKQYKALEQR--- 619

  Fly   910 QHGILTQCIKQFTVERKCN-------NQTIGNILLKINSKLNGINHKIKDDPRLPMMKNTMYIGA 967
                 |..|.|.....|.|       ..|:.||:.|.|.||.|:|:.: .|.:..|....:.||.
 Worm   620 -----TMMIVQDMKISKANAVVKDGKRLTLENIINKTNVKLGGLNYTV-SDAKKSMTDEQLIIGV 678

  Fly   968 DVTHPSPDQREI--------PSVVGVA----ASHD--------PYGASYNMQYRLQRGALEEIED 1012
            .|:.|....:.:        |.::|.|    |:|:        |.|          :..:..|||
 Worm   679 GVSAPPAGTKYMMDNKGHLNPQIIGFASNAVANHEFVGDFVLAPSG----------QDTMASIED 733

  Fly  1013 MFSITLEHLRVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQACDKVGCKPKICCVIVV 1077
            :...:::   ::::.|.|.|..||.||.|.|:|....|...|:...:........:.|:..::|.
 Worm   734 VLQNSID---LFEKNRKALPKRIIIYRSGASEGSHASILAYEIPLARAIIHGYSKEIKLIFIVVT 795

  Fly  1078 KRHHTRFF----PSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIE 1138
            |.|..|||    .||...|.   .|:.||.|:|..:.:|...|||:..|..:|||||...|.|:.
 Worm   796 KEHSYRFFRDQLRSGGKATE---MNIPPGIVLDNAVTNPACKQFFLNGHTTLQGTAKTPLYTVLA 857

  Fly  1139 NTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGR 1183
            :.....:|.|::||:.|||.....:.|.|.|.|.|:|:..|.|||
 Worm   858 DDCKAPMDRLEELTFTLCHHHQIVSLSTSIPTPLYVANEYAKRGR 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	20/87 (23%)
		ArgoL1	554..601	CDD:462567	12/64 (19%)
		PAZ	605..719	CDD:239207	26/118 (22%)
		Piwi_ago-like	764..1186	CDD:240015	115/458 (25%)
wago-1	NP_492045.1	PAZ_argonaute_like	320..430	CDD:239212	26/118 (22%)
		Piwi	598..905	CDD:214930	90/330 (27%)