Protein Alignment AGO2 and ppw-2

DIOPT Version :9

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: NP_491535.1
• Gene: ppw-2 / 172152
• WormBaseID: WBGene00004094
• Length: 975
• Species: Caenorhabditis elegans
• Alignment Length: 982
• Identity: 207/982 - (21%)
• Similarity: 369/982 - (37%)
• Gaps: 206/982 - (20%)

  Fly   370 PPGQQPNQTQSQGQYQSRGPPQQQQAAPLPLPPQPAGS---------IKR--------------- 410
            |||..|             ||   ...|:|:|..|..|         |||
 Worm    25 PPGLHP-------------PP---PVPPVPVPTLPVTSEHKTAHDACIKRLEQLEIPPDPKIYPS 73

  Fly   411 ----GTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPERPKK----FYRQAFEQFRV---DQLG 464
                ||.|...:|..|...:::.| .|..|.|.|.|..|...|    |.::..|.|.|   .:..
 Worm    74 PTEPGTFGSVTEVLTNVFGVEVHK-TSNFYQYSVHITAELSSKKEVTFTKKGKEDFIVHDRHEKC 137

  Fly   465 GAVL------------------AYDGKASCYS----VDKLP---LNSQNPEVTVTDRNGRTL--- 501
            .|:|                  .|||::..::    .:.:|   :.::..::...|.|.:.|
 Worm   138 SAILFHALNRFEDFFKSSENCIIYDGQSILFTSMNLFEGIPTGKIKTKVFQINGADTNLKDLMVL 202

  Fly   502 ---------------RYTIEI--KETGDSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHN 549
                           .:::|.  :.|.||.|:..::.   ..:|.|   .||....:...|.|
 Worm   203 PCIKLEVFPTKNPVVNFSLEDIGRRTSDSNIESVNMA---YKQILD---LAMSQYAIRETSKC-- 259

  Fly   550 KAIRVGRSFF-----KMSDPNNRHELDDGYEALVGLYQAFMLGDRPFLNVDISHKSFPI-SMPMI 608
            .....|:.||     :...|.:..|:.||.:...||.:.....:.|: ..:.::.|..| .|.:.
 Worm   260 VVFEHGKMFFINPLQEGYAPCDIVEVGDGKQMKPGLKKTLQFIEGPY-GRNQNNPSIVIDGMKVA 323

  Fly   609 EYLERFSLKAKINNTTNL-----DYSRRFLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPAS 668
            .::|:...:...:.|:||     ...|......::|::.    ..:::...|.:::..:....|:
 Worm   324 FHMEQLVFQKLSSITSNLANGITGSERERCAAVIKGLDC----HSNYRGRTRHHKIESIHHEGAA 384

  Fly   669 SETFE-HDGKKVTIASYFHSR-NYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALN-RKDGA 730
            :..|| ..|...|:|:||..: ...|::|..:.:...........|:||.:|...|.:. .:..:
 Worm   385 TARFELEGGGTCTVATYFKDKYKIQLRYPNANLIVCKERGALNFYPMELITISPNQRVRITQQTS 449

  Fly   731 TQVANMIKYAATSTNVRKRKIMN---LLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEY 792
            :|.....|.:|...::|:|.||.   ..:....|  ..:.:.|:.:.::.:||..|.|  |.:..
 Worm   450 SQSQRTTKESAVLPDIRQRLIMTGKIAAKITAEN--EVLGKMGVTVCDEPLVVKGRNL--PAIRL 510

  Fly   793 HS----KRFTMVKNGSWRMDGMKFLEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKA 853
            .|    :.....::..||..........||..   .||.....|.:||...:..|.:      :.
 Worm   511 ASFETGEHLINPRDCKWRPQRYNRSAVAPKVW---ALYGVGSPGSQMNRDVMRRFCD------EF 566

  Fly   854 VNISLDSDVTYRPFTD-DERSLDTIFADLKRSQHDLAIVIIPQFRISYDTIKQKAE-LQHGILTQ 916
            :|:|....:.:.|..| :..:.|.|...|:.:.:.....::.....:...:.||.: ::|.  ||
 Worm   567 MNMSRSKGILFPPPGDVNLLTPDAIENRLREAANAGCTFVLCITEDNITCLHQKYKFIEHH--TQ 629

  Fly   917 CI-------KQFTVERKCNNQTIGNILLKINSKLNGINHKIKDDPRLPMMKNTMYIGADVTHPSP 974
            .|       |..:|.......|:.|::.|.|.||.|.|:...|...  .::..:.||..::.|.|
 Worm   630 MIVQDMKLSKALSVVNASKKLTLENVINKTNVKLGGSNYVYLDTKN--FLQEHLIIGVGISSPPP 692

  Fly   975 DQREI--------PSVVGVAASHDPYGAS----YNMQYRLQRGALEEIEDMFSITLEHLRVYKEY 1027
            ..:.|        |::||.|     |..:    ::..:.|.....|.|..:..|....::.||::
 Worm   693 GTKYIMESRGILNPTIVGFA-----YNGNGKQEFSGDFVLNAAGQETIAPIEDIVSYSIKGYKKF 752

  Fly  1028 RNA-YPDHIIYYRDGVSDGQFPKIKNEELRCIKQACDKVGCKPKICCVIVVKRHHTRFF------ 1085
            .:. .|..|..||.|.|:|....|.:.|:...:.|........::..::|.|.|..|||
 Worm   753 HDGKAPKRITIYRSGSSEGNHGPIISYEVPLARVAMRNFSPDTQLLYIVVSKEHTYRFFKKESGG 817

  Fly  1086 -PSGDVTTSNKFN--------------NVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYN 1135
             .||...::...|              |:.||..||..:.:|...|||:.||..:||:||...|.
 Worm   818 SSSGGSNSAGASNSGTLTSAPPKPWELNIGPGLTVDYGVTNPACKQFFLNSHMTLQGSAKTPLYT 882

  Fly  1136 VIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVYLTGTNRFLDLKKEYA 1200
            |:.:..|:.:..|::.|:||||:........|.|.|.|:|:..|.|||          :|..|..
 Worm   883 VLADDRNIGMSALEEFTFNLCHLHQIVGLPTSIPTPLYVANEYAKRGR----------NLWNEAI 937

  Fly  1201 KRTIVPE 1207
            ....:||
 Worm   938 NANEIPE 944

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	185/884 (21%)
		ArgoN	411..543	CDD:293095	35/183 (19%)
		ArgoL1	554..601	CDD:285861	10/51 (20%)
		PAZ	605..719	CDD:239207	21/120 (18%)
		Piwi_ago-like	764..1186	CDD:240015	109/468 (23%)
ppw-2	NP_491535.1	PLN03202	64..919	CDD:215631	182/890 (20%)
		ArgoN	78..>189	CDD:293095	23/111 (21%)
		PAZ	334..461	CDD:198017	23/130 (18%)
		Piwi	604..934	CDD:280353	86/348 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870