DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and ppw-1

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_491323.2	Gene:	ppw-1 / 172013	WormBaseID:	WBGene00004093	Length:	887	Species:	Caenorhabditis elegans

Alignment Length:	925	Identity:	220/925 - (23%)
Similarity:	370/925 - (40%)	Gaps:	190/925 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 QTQSQGQYQSRGP--PQQQQAAPLPLPPQPAGSIKRGT-----------IGKPGQ------VGIN 422
            :.|.:..:.|..|  |..|:....||..:...:::|||           ..||.|      |.:|
Worm     2 EKQLEAMFVSDRPAAPAAQKLGTAPLAAKKTRNVERGTKVNIDTNIRKLTIKPNQPIYKYAVQVN 66

  Fly   423 YL---------DLDLSKMPSVAYHYDVKIMPERPKKFYRQAFEQFRVDQLGGAVLAYDGKASCYS 478
            |:         .:::||.......:|..  ..|.:|.|.:|.:::...:.||... ||.:||.|:
Worm    67 YVFRKPDGTEATIEMSKSAKKGTEHDND--KTRCQKVYNEAIKRYDELKTGGPFF-YDRQASLYT 128

  Fly   479 VDKLPLNSQNPEVTVTDR-----NGRTLRYTI-EIKETGDSTIDLKSLTTYMNDRIFDKPMRAMQ 537
            :.|  |.:::....|||:     |.:..::.: ::.::..||.:....||.......||.:  ::
Worm   129 LTK--LKNESISFVVTDKICKRQNFKEAQFVLKKVDQSFQSTSNDVIRTTNSCPANADKTL--LE 189

  Fly   538 CVEVVLASPC-HNK-AIRVGRSFFKMSDPNNRHELDDGYE--ALVGLYQAFMLG----------- 587
            .:.::::.|. .|| .|.||.....:.||.   .:|..|:  |...||..  :|
Worm   190 AMNIIVSGPAFENKNVITVGACVHYLIDPT---VVDVAYKEYAEGQLYSG--VGASKSVKTLEGT 249

  Fly   588 DRP----FLNVDISHKSF-PISMPMIEYLERF-----SLKAKINNTTNLDYSRRFLEPFLRGINV 642
            |:.    |:..::....| |...|::|.|:.|     :|||      |...::|..:.|: |::|
Worm   250 DKKVPSLFMTTEMKTTLFHPDYAPLVELLQTFRGFSTTLKA------NSPAAQRIEKAFV-GLDV 307

  Fly   643 VYTPPQSFQSAPRVYRVN-GLS-----------RAPASSETFEHDGKK---VTIASYFHSR-NYP 691
            |..           |.|: ||.           ...|....||.:...   ..:..||..: ...
Worm   308 VLN-----------YGVHKGLGEDGVVMKIRRFHTSAKETCFEVEKSTREFTNVFDYFKKKYGIT 361

  Fly   692 LKFPQLHCLNVGSSIKSILLPIE---LC---SIEEGQALNRKDGATQVANMIKYAATSTNVRKR- 749
            ||:|.|..:........|..|.|   ||   ::...|.:|.:.     |:|||.:|...::||.
Worm   362 LKYPDLFTIEAKGKQGKIHFPAEVLLLCPNQTVTNDQMINNEQ-----ADMIKMSAAQPHIRKTT 421

  Fly   750 --KIMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEYHSKRFTMVKNGSWRMDGMKF 812
              .|:..:....:|:      :|.....|.:.:...||..|::.:...:...:.|...|.
Worm   422 TDTIVRNVGLASNNI------YGFIKVEDPVNLEGMVLPKPKIAFAGNQLADLANPKSRF----- 475

  Fly   813 LEPKPKAHKCAVLYCDPRSGRK--MNYTQLNDFGNL-------IISQG-KAVNISLDSDVTYRPF 867
                |.....|..|.|.:...|  :.:.|..:...|       :::.| |..|.::...:
Worm   476 ----PTDFNRAGQYYDAKELTKWELVFVQNEEVQGLAKQLADEMVNNGMKCSNPTMSFII----- 531

  Fly   868 TDDERSLDTIFADLKRSQHDLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTVERKCNN-QT 931
               ...|:.||...|.:...|...:: :.|.:|....:..|.::.:|||.|:..|.|:.... ||
Worm   532 ---RGDLEPIFKKAKAAGTQLLFFVV-KSRYNYHQQIKALEQKYDVLTQEIRAETAEKVFRQPQT 592

  Fly   932 IGNILLKINSKLNGINHKIKDDP-RLPMMKNTMYIGADVTHPSPDQREIPSVVGVAAS----HDP 991
            ..||:.|.|.||.|:|:.|..:. ..|   |.:.:|...:.......:.|..||.||:    |..
Worm   593 RLNIINKTNMKLGGLNYAIGSEAFNKP---NRLIVGFVTSQRVGGNPDYPISVGFAANMLKHHQK 654

  Fly   992 YGASYNMQYRLQRGALEEIEDMFSITLEH--LRVYK---EYRNAYPDHIIYYRDGVSDGQFPKIK 1051
            :...|...:|        ..|:|...::.  |.::|   |.|.. ||.|:.|.:|||:|||..|.
Worm   655 FAGGYVYVHR--------DRDVFGSIIKDTLLAIFKTCTEQRGR-PDDILLYFNGVSEGQFSMIN 710

  Fly  1052 NEELRCIKQAC---DKVGC---KPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIV 1110
            .|....:|:||   .|.|.   :|.|..:...|.|:.|.:.|    ...:..|::||||||.|||
Worm   711 EEFSARVKEACMAFQKEGTPPFRPHITIIASSKAHNERLYKS----DKGRIVNLEPGTVVDHTIV 771

  Fly  1111 HPNEMQFFMVSHQAIQGTAKPTRYNVIENT--GNLDIDL--LQQLTYNLCHMFPRCNRSVSYPAP 1171
            .....:::..|..|.|||||.|::.:|..|  |.....|  |:|||.:||:........|..|.|
Worm   772 SNVYTEWYHASAVARQGTAKATKFTLIFTTKAGPQAEPLWHLEQLTNDLCYDHQIVFHPVGLPVP 836

  Fly  1172 AYLAHLVAARGRVYL 1186
            .|:|...:.||.:.|
Worm   837 LYIADRYSQRGAMVL 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	209/881 (24%)
		ArgoN	411..543	CDD:293095	34/163 (21%)
		ArgoL1	554..601	CDD:285861	12/63 (19%)
		PAZ	605..719	CDD:239207	31/140 (22%)
		Piwi_ago-like	764..1186	CDD:240015	117/452 (26%)
ppw-1	NP_491323.2	PAZ_argonaute_like	272..389	CDD:239212	29/134 (22%)
ppw-1	NP_491323.2	Piwi-like	444..849	CDD:239208	116/438 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010