Protein Alignment AGO2 and AGO1

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: XP_061517419.1
• Gene: AGO1 / 1280922
• VectorBaseID: AGAMI1_003573
• Length: 955
• Species: Anopheles gambiae
• Alignment Length: 976
• Identity: 301/976 - (30%)
• Similarity: 447/976 - (45%)
• Gaps: 143/976 - (14%)

  Fly   343 YQQRPSGQQQGGHQQGRQGQEGGYQQRPPGQQPNQTQSQGQYQSRGPP----------------- 390
            |....:..|..|...|:...|..:...|| :.|:.:|||..:.:..||
Mosquito    20 YSDMATHIQLNGVIMGKSFNESPWTSSPP-RPPSPSQSQTSFDTLSPPPAGATVNPTTVATTTGT 83

  Fly   391 QQQQA-----APLPLPPQ-PAGSIKR----GTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPE 445
            |..||     |..|.||. |..:..|    |..|:|..:..|:..:.:.:  ...:|||:.|.|:
Mosquito    84 QGAQALGVVPATPPAPPDLPVFTCPRRPNLGREGRPIVLRANHFQITMPR--GFVHHYDINIQPD 146

  Fly   446 R-PKKFYRQAFEQF--RVDQLGGAVL-AYDGKASCYSVDKLPLNSQNPEVTVT---DRNGRTLRY 503
            : |:|..|:..|..  ...::.||:. .:||:.:.|:.|.||:.:...|:.||   :...|..|.
Mosquito   147 KCPRKVNREIIETMVHAYSKMFGALKPVFDGRNNLYTRDLLPIGNDRVELEVTLPGEGKDRVFRV 211

  Fly   504 TIEIKETGDSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAIRVGRSFFKMSDPNNRH 568
            ||:    ..:.:.|.:|...:..|....|..|:..::||:..........||||||...| ...|
Mosquito   212 TIK----WVAQVSLFNLEEALEGRTRQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPD-GYYH 271

  Fly   569 ELDDGYEALVGLYQAFMLGDRP-----FLNVDISHKSFPISMPMIEYL-ERFSLKAKINNTTN-- 625
            .|..|.|...|.:|:.    ||     .||:|:|..:|..:.|:||:: |...:: .||....
Mosquito   272 PLGGGREVWFGFHQSV----RPSQWKMMLNIDVSATAFYKAQPVIEFMCEVLDIR-DINEQRKPL 331

  Fly   626 LDYSRRFLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETFE---HDGKKV--TIASYF 685
            .|..|......::|:.:..|...:.:   |.|||..::|.||..::|.   .:|:.|  |:|.||
Mosquito   332 TDSQRVKFTKEIKGLKIEITHCGTMR---RKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYF 393

  Fly   686 HSR-NYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKR 749
            ..: ...|::|.|.||.||...|...||:|:|:|..||...:|....|.:.|||..|.|...|:|
Mosquito   394 LDKYKMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDRER 458

  Fly   750 KIMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEYHSK----------------RFT 798
            :|.||::....|.|..:..||:.|:|:.:.|..|||.||:::|..:                ...
Mosquito   459 EINNLVRRADFNNDAYVQEFGLTISNNMMEVRGRVLPPPKLQYGGRVSSMSGQLLSGPQNKVSLA 523

  Fly   799 MVKNGSWRMDGMKF---LEPKPKAHKCAVLYCDPRSGRKMNYTQ-----LNDFGNLIISQGKAVN 855
            :...|.|.|.|.:|   :|.:..|..|.......|.....|:||     .||.|..||.|.....
Mosquito   524 LPNQGVWDMRGKQFFTGVEIRVWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCK 588

  Fly   856 ISLDSDVTYRPFTDDERSLDTIFADLKRSQHDLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQ 920
            .:...|.....|    |.|.:.|:.|:     |.:|::|.....|..:|:..:...|:.|||::.
Mosquito   589 YATGPDQVEPMF----RYLKSTFSHLQ-----LVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQA 644

  Fly   921 FTVERKCNNQTIGNILLKINSKLNGINH--------KIKDDPRLPMMKNTMYIGADVTHPSPDQR 977
            ..| .|.:.||:.|:.||||.||.|||.        |:.|:|       .:::|||||||.....
Mosquito   645 KNV-NKTSPQTLSNLCLKINVKLGGINSILVPSIRPKVFDEP-------VIFLGADVTHPPAGDN 701

  Fly   978 EIPSVVGVAASHDPYGASYNMQYRLQRGALEEIEDMFSITLEHL-RVYKEYRNAYPDHIIYYRDG 1041
            :.||:..|..|.|.:.:.|....|:|:...|.|:::.|:..|.| ..||......|..||.||||
Mosquito   702 KKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIIQELSSMVRELLIMFYKSTGGFKPHRIILYRDG 766

  Fly  1042 VSDGQFPKIKNEELRCIKQACDKVGC--KPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTV 1104
            ||:||||.:...||..|::||.|:..  ||.|..::|.||||||.|.:.....|.|..|:..||.
Mosquito   767 VSEGQFPHVLQHELTAIREACIKLEADYKPGITFIVVQKRHHTRLFCADKKEQSGKSGNIPAGTT 831

  Fly  1105 VDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYP 1169
            ||..|.||.|..|::.|||.||||::|:.|:|:.:..:.:.|.||.|||.|||.:.||.||||.|
Mosquito   832 VDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFESDELQCLTYQLCHTYVRCTRSVSIP 896

  Fly  1170 APAYLAHLVAARGRVYLTGTNRFLDLKKEY-------------------AKRTIVPEFMKKNPMY 1215
            ||||.|||||.|.|.:|        ::||:                   ..|.|......|..||
Mosquito   897 APAYYAHLVAFRARYHL--------VEKEHDSGEGSHQSGCSEDRTPGAMARAITVHADTKKVMY 953

  Fly  1216 F 1216
            |
Mosquito   954 F 954

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	19/74 (26%)
		ArgoL1	554..601	CDD:462567	19/51 (37%)
		PAZ	605..719	CDD:239207	36/122 (30%)
		Piwi_ago-like	764..1186	CDD:240015	162/456 (36%)
AGO1	XP_061517419.1	None