DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO2 and ago4

DIOPT Version :9

Sequence 1:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster
Sequence 2:	NP_001239488.1	Gene:	ago4 / 100535764	ZFINID:	ZDB-GENE-030131-5357	Length:	863	Species:	Danio rerio

Alignment Length:	849	Identity:	276/849 - (32%)
Similarity:	419/849 - (49%)	Gaps:	84/849 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 GPPQQQQAAPLPL--PPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPE-RPKK 449
            |||     ||..|  ||:..|   .||:|||.::..|:..:.:.|:.  .||||:.|.|| ||::
Zfish     7 GPP-----APTSLFQPPRRPG---LGTVGKPIRLLANHFQVQIPKID--VYHYDIDIKPEKRPRR 61

  Fly   450 FYRQAFE----QFRVDQLGGAVLAYDGKASCYSVDKLPLNSQNPEVTVT-DRNGRTLRYTIEIKE 509
            ..|:..:    .|::...|.....||||.:.|:...||:.....::.|| ...|:...:.:.::.
Zfish    62 VNREVVDTMVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDLEVTLPGEGKDQTFKVSLQW 126

  Fly   510 TGDSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAIR---VGRSFFKMSDPNN-RHEL 570
            .  |.:.|:.|...::..:.:.|..::|.::|:..   |..::|   ||||||  |.|.. .|.|
Zfish   127 V--SVVSLQMLLEALSGHLNEVPEDSVQALDVITR---HLPSMRYTPVGRSFF--SPPEGYYHPL 184

  Fly   571 DDGYEALVGLYQAFMLGDRP-----FLNVDISHKSFPISMPMIEYLERFSLKAKINNTTN--LDY 628
            ..|.|...|.:|:.    ||     .||:|:|..:|..:.|:||::........||..|.  .|.
Zfish   185 GGGREVWFGFHQSV----RPAMWNMMLNIDVSATAFYRAQPVIEFMCEVLDIQNINEQTKPLTDS 245

  Fly   629 SRRFLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETFE---HDGK--KVTIASYFHSR 688
            .|......:||:.|..|.....:   |.|||..::|.|||.:||.   .:|:  :.|:|.||..:
Zfish   246 QRVKFTKEIRGLKVEVTHCGQMK---RKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQK 307

  Fly   689 -NYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIM 752
             :..||:|.|.||.||...|...||:|:|:|..||...:|....|.:.|||..|.|...|:.:|.
Zfish   308 YSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEIS 372

  Fly   753 NLLQYFQHNL----DPTISRFGIRIANDFIVVSTRVLSPPQVEYHSKRFTMV--KNGSWRMDGMK 811
            .|::  .:::    ||.:..|||.:.||...|:.|||..|.::|..:..|:.  ..|.|.|.|.:
Zfish   373 RLVK--SNSMVGGPDPYLKEFGIVVHNDMTEVTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQ 435

  Fly   812 F---LEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISLDSDVTYRPFTDDERS 873
            |   :|.|..|..|..    |:  ::.....|..|.:.:....|...:.:.....:..:.....|
Zfish   436 FYAGIEIKVWAVACFA----PQ--KQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADS 494

  Fly   874 LDTIFADLKRSQ--HDLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTVERKCNNQTIGNIL 936
            ::.:|..||.|.  ..|.:||:|.....|..:|:..:...|:.|||::...|. |.:.||:.|:.
Zfish   495 VEPMFKHLKMSYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVV-KTSPQTLSNLC 558

  Fly   937 LKINSKLNGINHKIKDDPRLPMMKN-TMYIGADVTHPSPDQREIPSVVGVAASHDPYGASYNMQY 1000
            ||||:||.|||:.:....|..:.:. .:::|||||||.....:.||:..|..|.|.:.:.|....
Zfish   559 LKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATV 623

  Fly  1001 RLQRG----------ALEEIEDMFSITLEHL-RVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEE 1054
            |:|..          :.|.|:|:.::..|.| :.||..| ..|..|||||.|||:||..::...|
Zfish   624 RVQTSRQDLSQEQLFSQEVIQDLTNMVRELLIQFYKSTR-FKPTRIIYYRGGVSEGQMKQVAWPE 687

  Fly  1055 LRCIKQACDKV--GCKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQF 1117
            |..|::||..:  ..:|.|..::|.||||||.|.|.......|..||..||.||.||.||:|..|
Zfish   688 LIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCSDKAERVGKSGNVPAGTTVDSTITHPSEFDF 752

  Fly  1118 FMVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARG 1182
            ::.||..||||::|:.|:|:.:......|.||.|||.|||.:.||.||||.|||||.|.|||.|.
Zfish   753 YLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRA 817

  Fly  1183 RVYL 1186
            |.:|
Zfish   818 RYHL 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	263/816 (32%)
		ArgoN	411..543	CDD:293095	35/137 (26%)
		ArgoL1	554..601	CDD:285861	20/52 (38%)
		PAZ	605..719	CDD:239207	40/121 (33%)
		Piwi_ago-like	764..1186	CDD:240015	154/442 (35%)
ago4	NP_001239488.1	ArgoN	28..157	CDD:406799	31/132 (23%)
		ArgoL1	168..218	CDD:400854	21/55 (38%)
		PAZ_argonaute_like	219..339	CDD:239212	40/122 (33%)
		Piwi_ago-like	386..821	CDD:240015	154/442 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58336
OrthoDB	1	1.010	-	-		D159407at2759
OrthoFinder	1	1.000	-	-		FOG0000468
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.030