Protein Alignment AGO2 and piwil3

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: XP_031752134.1
• Gene: piwil3 / 100496286
• XenbaseID: XB-GENE-6469412
• Length: 869
• Species: Xenopus tropicalis
• Alignment Length: 1037
• Identity: 229/1037 - (22%)
• Similarity: 389/1037 - (37%)
• Gaps: 251/1037 - (24%)

  Fly   262 GHQQGR-QGQEGGYQQRPPGQQQGGHEQGRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPS 325
            |..:.| :|:..|.::.||||:              |.|||                    |||.
 Frog     3 GRARARARGRARGQERGPPGQE--------------YPQRP--------------------QRPP 33

  Fly   326 GQQQGGHQQGRQGQEGGYQQRPSGQQQ--GGHQQGRQGQEGGYQQRPPGQQPNQTQSQG------ 382
            .||....|.        :.|.|..:.:  |   :|||........||..:.|.|..|.|
 Frog    34 PQQFPPQQP--------FPQAPPAEPELVG---RGRQRGAAAAAVRPRAEDPVQEISAGFQEVTI 87

  Fly   383 --------QYQSRGPPQQQQAAPLPLPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYD 439
                    .:...|...:|..       :.....|.|..|...|:..|::.| :|:...|.|.|.
 Frog    88 SERGGRRRDFHDLGVNTRQTI-------EHVKESKTGVSGSTIQLSTNHIKL-VSRPQWVLYQYH 144

  Fly   440 VKIMPERPKKFYRQAFEQFRVDQLGGAVLAYDGKASCYSVDKLPLNSQNPEVTVTDRNGRTLRYT 504
            :...|:...:..|.|. .::.::|.|...|:|| ...::..:|   ::..||....|||..::.|
 Frog   145 IDYNPQMESRRLRTAL-LYQHEELIGKARAFDG-TMLFAPKRL---NKATEVFSQTRNGENVKIT 204

  Fly   505 I----EIKETGDSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAIRVGRSFFKMSDP- 564
            |    |:..|..:.....::       ||.:.::.|...:             :||:::..|||
 Frog   205 ITLTNELPPTSPTCFQFYNI-------IFRRLLKMMNMKQ-------------IGRNYYNPSDPI 249

  Fly   565 -NNRHELD--DGYEALVGLYQAFMLGDRPFLNVDISHKSFPISMPMIEYLERFSLKAKINNTTNL 626
             .::|.|.  .|:...:..|:..::     |::|:|||                   .:.:.|.|
 Frog   250 EISQHNLTIWPGFTTSILQYETSIM-----LSLDVSHK-------------------VLRSETVL 290

  Fly   627 DY---------SRRFLEPFLRGI--NVVYTPPQSFQSAPRVYRVNGLSRAPASSETF-EHDGKKV 679
            |.         .|.|.:...:.:  .:|.|...:     :.||::.:........|| :.||..:
 Frog   291 DVMTKLYRMHGDRDFADAVTKELLGQIVLTKYNN-----KTYRIDEICWNMTPQSTFKKSDGSDI 350

  Fly   680 TIASYFHSR--------------NYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGA 730
            :...|:..:              |.|.:      :..|.....|:|..|||:: .|.....::..
 Frog   351 SFVDYYRMQYNKEIRDLRQALIANIPRR------VRPGGDTGPIVLVPELCNL-TGLTDRMRNDF 408

  Fly   731 TQVANMIKYAATSTNVRKRKIMNLLQYF--QHNLDPTISRFGIRIANDFIVVSTRVLSPPQ---- 789
            ..:.::..:.....:.|::::...|.|.  ..|:...:..:|:......:....|| |||:
 Frog   409 GVMRDLAVHTRLPPDQREKQVARFLNYIHKDENVQKELRDWGLNFDKQLLPFVGRV-SPPERILQ 472

  Fly   790 ----VEYHSKRFTMVKNGSWRMDGMKFLEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQ 850
                .:|:.:    ..:.|..|.|...:..: ......:||  ||.......|.:.....:....
 Frog   473 AGRTADYNPQ----FADWSREMRGQTLISVR-HLDNWMLLY--PRRCYDAAQTLVQTLNKVAQQI 530

  Fly   851 GKAVNISLDSDVTYRPFTDDERS---LDTIFADLKRSQHDLAIVIIPQFRISYDTIKQKAELQHG 912
            |..:|       ..|.|..|:|:   :..:.|::......:..|:....:..||:||:...||..
 Frog   531 GMRMN-------NVRMFEVDDRANSYIQVLNAEVNPDTQMVVCVLSSIHKEKYDSIKKYLCLQIP 588

  Fly   913 ILTQCIKQFTVERKCNNQTIGNILLKI----NSKLNGINHKIKDDPRLPMMKNTMYIGADVTHPS 973
            ..:||:...|:.:.   ||:.::..||    |.|:.|....::    :| :...|.||.|..|.:
 Frog   589 TPSQCVVARTLSKP---QTVLSVATKIAMQMNCKMGGELWSVE----IP-LGEMMVIGIDCYHDT 645

  Fly   974 PDQREIPSVVGVAASHDPYGASYNMQYRLQRGAL----EEIEDMFSITLE-HLRVYKEYRNAYPD 1033
            ...:.  |:.|..||     .:.|:.....|..|    :||.|...:.|: .|..:.......|.
 Frog   646 LSGKR--SIAGFVAS-----MNRNLTRWYSRCVLQDQKQEIVDGLKVCLQASLHAWFNCNKNLPS 703

  Fly  1034 HIIYYRDGVSDGQFPKIKNEE----LRCIKQA----CDKVGCKPKICCVIVVKRHHTRFFPSGDV 1090
            .|:.|||||.|||...:.|.|    |.|||.|    |      ||:..::|.||.:.|||    .
 Frog   704 RILIYRDGVGDGQLKTLVNYEIPQFLDCIKSAGRDYC------PKLSIIVVKKRINARFF----A 758

  Fly  1091 TTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNL 1155
            ....:..|..||||||..:..|....||:||....|||..||.|||:.::..|..|.:|:|||.|
 Frog   759 HLGGRIQNPPPGTVVDVEVTRPEWYDFFIVSQSVRQGTVSPTHYNVVYDSSGLKPDYMQRLTYKL 823

  Fly  1156 CHMFPRCNRSVSYPAPAYLAHLVAARGRVYLTGTNRFLDLKKEYAKRTIVPEFMKKNPMYFV 1217
            ||::......:..|||...||.:|     :|.|.:    :.||       |.....|.:|::
 Frog   824 CHLYYNWPGVIRVPAPCQYAHKLA-----FLVGQS----IHKE-------PHLALSNRLYYL 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	15/75 (20%)
		ArgoL1	554..601	CDD:462567	14/50 (28%)
		PAZ	605..719	CDD:239207	22/139 (16%)
		Piwi_ago-like	764..1186	CDD:240015	118/449 (26%)
piwil3	XP_031752134.1	GAGE	<75..117	CDD:461753	6/48 (13%)
		PAZ	287..423	CDD:198017	23/147 (16%)
		Piwi_piwi-like_Euk	410..852	CDD:240016	123/486 (25%)