Protein Alignment AGO2 and piwil4

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: XP_012813692.2
• Gene: piwil4 / 100486962
• XenbaseID: XB-GENE-993661
• Length: 853
• Species: Xenopus tropicalis
• Alignment Length: 924
• Identity: 204/924 - (22%)
• Similarity: 363/924 - (39%)
• Gaps: 199/924 - (21%)

  Fly   323 RP----SGQQQGGHQQGRQGQEGGYQQRPSGQ------QQGGHQQGRQGQEGGYQQRPPGQQPNQ 377
            ||    |...||.......|::.|.....:|:      ::|| :.||..|:.|...|       |
 Frog    34 RPDAGSSKDLQGIGSGNGSGRDSGIGTISAGENRYVLAERGG-RNGRNLQDFGINTR-------Q 90

  Fly   378 TQSQGQYQSRGPPQQQQAAPLPLPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVKI 442
            |.:.                       ....|.||.|.|.::..|...|.|.....: |.|.|..
 Frog    91 TMAH-----------------------VKDHKTGTSGAPVKLMTNLFGLTLPTQWKL-YQYRVDF 131

  Fly   443 MPERPKKFYRQAFEQFRVDQLGGAVLAYDGKASCYSVDKLPLNSQNPEVTVTDRNGRTLRYTIEI 507
            .||...:..:.|......:.||.| .|:.|:....|.:...||    .:..|.|.|.|::.||.:
 Frog   132 SPEFASRKLKTALLYSHGETLGRA-RAFHGEILFLSRNIGKLN----HLESTTRKGETVKITITL 191

  Fly   508 KE--TGDSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAIRVGRSFFKMSD----PNN 566
            ..  ..||.:.::....     :|.|..:::...:             |||:::..:|    |.:
 Frog   192 TNQLPADSPVCIQFFGI-----LFKKVFKSLNMYQ-------------VGRNYYNPADPVIIPQH 238

  Fly   567 RHELDDGYEALVGLYQAFMLGDRPFLNVDISHKSFPISMPMIEYLERFSLKAKINNTTNLD---- 627
            |..|..|:     :.....|..:..|..|:|||                   .:.|.|.||
 Frog   239 RLMLWPGF-----VLSIMKLESQLALCADVSHK-------------------VLRNETVLDSMKA 279

  Fly   628 -YSR----RF---LEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETF-EHDGKKVTIAS 683
             ||:    ||   .|..|.|: ||.|...:     :.|||:.:..:...:::| ..||.::|...
 Frog   280 LYSKVPKERFTDICEKELLGL-VVLTRYNN-----KTYRVDDIDWSTKPTDSFPRKDGSEITYTD 338

  Fly   684 YFHSRNYPLKFPQLHCLNVGSSIKS------------ILLPIELCSIEEGQALNRKDGATQVANM 736
            |: |:.|.:....|....:.|::|:            .|:| |||.:   ..|:.:  |.....:
 Frog   339 YY-SQQYSINISDLQQPMLVSTLKAKKSDNPDAPRAVHLIP-ELCYL---TGLSSR--ALSDFRL 396

  Fly   737 IKYAATSTNV----RKRKIMNLLQYFQHNLDPT--ISRFGIRIANDFIVVSTRVLSPPQVEYHSK 795
            :|..:..|.:    |::::..|....|...:.:  :.::|:|:... |.|:.|:..|.::.....
 Frog   397 MKDLSMETQLDPERRQQRLQRLADSIQRTPEASAELEKWGLRMDKQ-IPVTGRIAPPERIFMRDN 460

  Fly   796 RFTMVKNGSWRMDGMKFLEPKPKAHKCAVLYCDPRSGRKM--NYTQLNDFGNLI-----ISQGKA 853
            ..|......|..|          .....|:...|.....|  :|...:...||:     ::.|..
 Frog   461 VCTPGSPADWARD----------TRNEKVICVAPLQNWLMLFSYRNADVAENLLQCLMKVASGMG 515

  Fly   854 VNISL-------DSDVTY-----RPFTDDERSLDTIFADLKRSQHDLAIVIIPQFRISYDTIKQK 906
            .::.:       |:.|::     :..|.|   |..:|..:..:|.|           |||:||:.
 Frog   516 FHMDMPRIVQVEDNPVSFLRTLQKNVTPD---LQLVFCVIPTNQKD-----------SYDSIKKF 566

  Fly   907 AELQHGILTQCIKQFTVERKCNNQTIGN-ILLKINSKLNGINHKIKDDPRLPMMKNTMYIGADVT 970
            ..|...:.:||::..|:.|:....::.| |.:::..||.|....::    :| :|..|.:|.|:.
 Frog   567 LSLDQPVPSQCVQNRTLGRQQMMMSVANKIAMQMICKLGGELWAVE----IP-LKALMVVGIDIN 626

  Fly   971 HPSPDQREIPSVVGVAASHDPYGASYNMQYRLQRGALEEIEDMFSITLE-HLRVYKEYRNAYPDH 1034
            ..:.::.  .||||..||.:.....::.:..:|: ...:..|...:.:: .::.::...|..|:.
 Frog   627 KDAVNKS--MSVVGFVASTNARLTRWHSRCIIQK-TTSDFADCLKMCMKGAIQNWQRCNNDLPNR 688

  Fly  1035 IIYYRDGVSDGQFPKIKNEELRCIKQAC--DKVGCKPKICCVIVVKRHHTRFFPSGDVTTSNKFN 1097
            |:.|||||.|||...:.:.|:..:..:.  .|....|::..::|.|:..:||:    ..|.....
 Frog   689 IVVYRDGVGDGQLKMVVDYEIPQLLSSFRETKTSYCPRLSVIVVRKKCISRFY----TQTGRGIQ 749

  Fly  1098 NVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRC 1162
            |...||:||.....|....|:::|..|.|||..||.|||:.:...|..|.:|:|||.|||::...
 Frog   750 NPVLGTIVDSEATRPEWYDFYLISQNARQGTVNPTYYNVLLDENGLKPDHMQRLTYKLCHLYYNW 814

  Fly  1163 NRSVSYPAPAYLAH 1176
            ...:..|||...||
 Frog   815 PGVIRVPAPCQYAH 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	14/73 (19%)
		ArgoL1	554..601	CDD:462567	14/50 (28%)
		PAZ	605..719	CDD:239207	32/138 (23%)
		Piwi_ago-like	764..1186	CDD:240015	102/438 (23%)
piwil4	XP_012813692.2	ArgoL1	222..269	CDD:462567	14/70 (20%)
		PAZ	271..409	CDD:198017	35/150 (23%)
		Piwi_piwi-like_Euk	395..836	CDD:240016	107/471 (23%)