Protein Alignment AGO2 and ago3

DIOPT Version :10

• Sequence 1: NP_730054.1
• Gene: AGO2 / 39683
• FlyBaseID: FBgn0087035
• Length: 1217
• Species: Drosophila melanogaster
• Sequence 2: XP_004911628.1
• Gene: ago3 / 100486574
• XenbaseID: XB-GENE-6462752
• Length: 861
• Species: Xenopus tropicalis
• Alignment Length: 838
• Identity: 271/838 - (32%)
• Similarity: 413/838 - (49%)
• Gaps: 76/838 - (9%)

  Fly   399 PLPPQPAGSIKR----GTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPER-PKKFYRQA---- 454
            |:..||...:.|    ||:|||.::..|...:::.|:.  .|.|:|.|.|:: |::..|:.
 Frog     8 PVGAQPFFMVPRRPGYGTMGKPIKLLANCFQVEIPKID--VYLYEVDIKPDKCPRRVNREVVDSM 70

  Fly   455 FEQFRVDQLGGAVLAYDGKASCYSVDKLPLNSQ--NPEVTVTDRNGRTLRYTIEIKETGDSTIDL 517
            .:.|:|...|.....||||.|.|:.:.||:.|.  :.:||:....|:...:.:.||..  |.|..
 Frog    71 VQHFKVTIFGDRRPVYDGKRSLYTANPLPVASTGVDLDVTLPGEGGKDRPFKVSIKFV--SRISW 133

  Fly   518 KSLTTYMNDRI------FDKPM--RAMQCVEVVLASPCHNKAIRVGRSFFKMSDPNNRHELDDGY 574
            ..|...:..|.      .|||:  ..:..|:|||......|...||||||...:..: |.|..|.
 Frog   134 HLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGYD-HPLGGGR 197

  Fly   575 EALVGLYQAFMLGDRP-----FLNVDISHKSFPISMPMIEYLERFSLKAKINNTTNLDYSRRFLE 634
            |...|.:|:.    ||     .||:|:|..:|..:.|:|:::      .::.:..|:|...|.|.
 Frog   198 EVWFGFHQSV----RPAMWKMMLNIDVSATAFYKAQPVIQFM------CEVLDIHNIDEQPRPLT 252

  Fly   635 PF--------LRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETFE---HDGKKV--TIASYFH 686
            ..        ::|:.|..|...:.:   |.|||..::|.|||.:||.   .:|:.|  |:|.||.
 Frog   253 DSHRVKFTKEIKGLKVEVTHCGTMR---RKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFR 314

  Fly   687 SR-NYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRK 750
            .: |..||:|.|.||.||...|...||:|:|:|..||...:|....|.:.|||..|.|...|:.:
 Frog   315 EKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEE 379

  Fly   751 IMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEYHSKRFTMV--KNGSWRMDGMKF- 812
            |..|::...::.||.:..|..::.::...|:.|||..|.::|..:..|:.  .:|.|.|.|.:|
 Frog   380 ISRLVRSANYDADPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFH 444

  Fly   813 --LEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISLDSDVTYRPFTDDERSLD 875
              :|.|..|..|..      :.|:.....|..|.:.:....|...:.:.....:..:.....|::
 Frog   445 TGVEIKMWAIACFA------TQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVE 503

  Fly   876 TIFADLKR--SQHDLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTVERKCNNQTIGNILLK 938
            .:|..||.  |...|.|||:|.....|..:|:..:...|:.|||::...| .|.:.||:.|:.||
 Frog   504 PMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNV-IKTSPQTLSNLCLK 567

  Fly   939 INSKLNGINHKIKDDPRLPMMKN-TMYIGADVTHPSPDQREIPSVVGVAASHDPYGASYNMQYRL 1002
            ||.||.|||:.:....|..:.:. .:::|||||||.....:.||:..|..|.|.:.:.|....|:
 Frog   568 INVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRV 632

  Fly  1003 QRGALEEIEDMFSITLEHL-RVYKEYRNAYPDHIIYYRDGVSDGQF-PKIKNEELRCIKQACDKV 1065
            ||...|.|.|:.|:..|.| :.||..| ..|..||:||||||:||| .::...||..|::||..:
 Frog   633 QRPRQEIIHDLASMVRELLIQFYKSTR-FKPTRIIFYRDGVSEGQFRQQVLYYELLAIREACISL 696

  Fly  1066 --GCKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGT 1128
              ..:|.|..::|.||||||.|.:.......:..|:..||.||..|.||.|..|::.||..||||
 Frog   697 EKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGT 761

  Fly  1129 AKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVYL 1186
            ::|:.|:|:.:......|.||.|||.|||.:.||.||||.|||||.|||||.|.|.:|
 Frog   762 SRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHL 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO2	NP_730054.1	ArgoN	471..543	CDD:465134	22/81 (27%)
		ArgoL1	554..601	CDD:462567	18/51 (35%)
		PAZ	605..719	CDD:239207	39/127 (31%)
		Piwi_ago-like	764..1186	CDD:240015	151/433 (35%)
ago3	XP_004911628.1	ArgoN	73..167	CDD:465134	26/95 (27%)
		ArgoL1	177..227	CDD:462567	19/54 (35%)
		PAZ_argonaute_like	228..348	CDD:239212	39/128 (30%)
		Piwi_ago-like	393..819	CDD:240015	151/433 (35%)