DRSC/TRiP Functional Genomics Resources

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Protein Alignment CrebA and CREB3L1

DIOPT Version :10

Sequence 1:NP_524087.3 Gene:CrebA / 39682 FlyBaseID:FBgn0004396 Length:516 Species:Drosophila melanogaster
Sequence 2:NP_001412195.1 Gene:CREB3L1 / 90993 HGNCID:18856 Length:557 Species:Homo sapiens


Alignment Length:521 Identity:156/521 - (29%)
Similarity:212/521 - (40%) Gaps:201/521 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 DLKDIWDSDL-----DPESLKISPDH---DMHDW---LFDRDVKDPTVILNDKLISDALLNGTQP 60
            ||.|:.:||.     .||.|    ||   :|.|:   ||.....||.:.....|:...|.:.|..
Human    21 DLGDLNESDFLNNAHFPEHL----DHFTENMEDFSNDLFSSFFDDPVLDEKSPLLDMELDSPTPG 81

  Fly    61 IKTEHSYSLSSDVDSLPDSPKSLQAKIEDMDDECFPAISPKTATNGRVTIDPKYLTFHVPPTHA- 124
            |:.|||||||.  ||.|.|| .:..|:||         :.:.|.:|...:..|..:..|....: 
Human    82 IQAEHSYSLSG--DSAPQSP-LVPIKMED---------TTQDAEHGAWALGHKLCSIMVKQEQSP 134

  Fly   125 -TPISRLSSNPALNTSVADLTRS-SGLQSL-QAHQPHHGSGSSHVVVANLEHFQLPQHLYDNDCS 186
             .|:..|::..|:..:.|..|.. .||..| :...||...|         |..|||         
Human   135 ELPVDPLAAPSAMAAAAAMATTPLLGLSPLSRLPIPHQAPG---------EMTQLP--------- 181

  Fly   187 SSVSSLRDGSMSPDICSDIEIDESAIKDEPMSPDSSCPASPTSQASSSQHQLSLNLAHLQSEMLF 251
                                    .||.||:..:.....:|                        
Human   182 ------------------------VIKAEPLEVNQFLKVTP------------------------ 198

  Fly   252 EPKHCGLLLTASSNSNNSLIKSQQRQQQILGQDNLLMAKMEIKSEKQSTSNSSDKSHAHGYGIPL 316
                                            ::|:.                         :|.
Human   199 --------------------------------EDLVQ-------------------------MPP 206

  Fly   317 TPPSSLPSDDSEGNLSPEHLFAPLSPNATVSISVANPAGGESSVR-VSRTAASITRSSSGSASAS 380
            |||||..| ||:|:.||..| .|.||                 || ::|::.:|:.|        
Human   207 TPPSSHGS-DSDGSQSPRSL-PPSSP-----------------VRPMARSSTAISTS-------- 244

  Fly   381 GSSTSSTVTTTRQPIHTPLISSQPK--GSTGTLLLTEEEKRTLLAEGYPIPQKLPLTKAEEKSLK 443
                             ||:::..|  |::|.|||||||||||:|||||||.||||||||||:||
Human   245 -----------------PLLTAPHKLQGTSGPLLLTEEEKRTLIAEGYPIPTKLPLTKAEEKALK 292

  Fly   444 KIRRKIKNKISAQESRRKKKEYMDQLERRVEILVTENHDYKKRLEGLEETNANLLSQLHKLQALV 508
            ::||||||||||||||||||||::.||::||...:||::..|::|.||..|..||.||.|||.||
Human   293 RVRRKIKNKISAQESRRKKKEYVECLEKKVETFTSENNELWKKVETLENANRTLLQQLQKLQTLV 357

  Fly   509 S 509
            :
Human   358 T 358

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CrebANP_524087.3 bZIP_CREB3 452..502 CDD:269837 28/49 (57%)
coiled coil 452..495 CDD:269837 24/42 (57%)
CREB3L1NP_001412195.1 Required for transcriptional activation 1..60 14/42 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 71..98 13/28 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 200..259 26/127 (20%)
bZIP_CREB3 291..344 CDD:269837 32/52 (62%)
Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 292..321 23/28 (82%)
coiled coil 293..344 CDD:269837 30/50 (60%)
Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 332..353 9/20 (45%)
MBTPS2 recognition. /evidence=ECO:0000303|PubMed:21767813 392..395
MBTPS1 recognition. /evidence=ECO:0000303|PubMed:21767813 423..426
Blue background indicates that the domain is not in the aligned region.

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