DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CrebA and CREB3L3

DIOPT Version :9

Sequence 1:	NP_524087.3	Gene:	CrebA / 39682	FlyBaseID:	FBgn0004396	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_115996.1	Gene:	CREB3L3 / 84699	HGNCID:	18855	Length:	461	Species:	Homo sapiens

Alignment Length:	387	Identity:	102/387 - (26%)
Similarity:	159/387 - (41%)	Gaps:	129/387 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 LEHFQLPQHLYDNDCSSSVSSLRDGSMSPDICSDIEIDE--SAIKDEPM--SPDS---------- 221
            ::.|:|...|:|.         :||     |...:|:.|  ..:||:.:  :|||
Human    20 IDSFELLDLLFDR---------QDG-----ILRHVELGEGWGHVKDQQVLPNPDSDDFLSSILGS 70

  Fly   222 --SCPASPTSQASSSQHQLSLNLAHLQSEMLFEPKHCGLLLTASSNSNNSLIKSQQRQQQILGQD 284
              |.|:||                      |:.|:                           |.|
Human    71 GDSLPSSP----------------------LWSPE---------------------------GSD 86

  Fly   285 NLLMAKMEIKSEKQSTSNSSDKSHAHGYGIPLTPPSSL-PSDDSEG---NLSPEHLFAPLSP--- 342
            :.:  ..::.|:.|.|...|.         |.|.|:.. |:...:|   :..|.:..:..:|
Human    87 SGI--SEDLPSDPQDTPPRSG---------PATSPAGCHPAQPGKGPCLSYHPGNSCSTTTPGPV 140

  Fly   343 ------NATVSISVANPAGG----------ESSVRVSRTAASITRS-SSGSASASGSSTSSTVTT 390
                  :.|:.:.:.:|.|.          :.|.|.:.|...:..| |||.........|..:
Human   141 IQVPEASVTIDLEMWSPGGRICAEKPADPVDLSPRCNLTVKDLLLSGSSGDLQQHHLGASYLL-- 203

  Fly   391 TRQPIHTPLISSQP-KGSTGTLLLTEEEKRTLLAEGYPIPQKLPLTKAEEKSLKKIRRKIKNKIS 454
                        :| .|....|:|||:||:.|..||..:|.:|||||.||:.||||||||:||.|
Human   204 ------------RPGAGHCQELVLTEDEKKLLAKEGITLPTQLPLTKYEERVLKKIRRKIRNKQS 256

  Fly   455 AQESRRKKKEYMDQLERRVEILVTENHDYKKRLEGLEETNANLLSQLHKLQALVSKHNVKKS 516
            |||||:|||||:|.||.|:.....:|.:.::::..||:.|.:||.||.||||:|.:...|.:
Human   257 AQESRKKKKEYIDGLETRMSACTAQNQELQRKVLHLEKQNLSLLEQLKKLQAIVVQSTSKSA 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrebA	NP_524087.3	bZIP_CREB3	452..502	CDD:269837	23/49 (47%)
CrebA	NP_524087.3	coiled coil	452..495	CDD:269837	19/42 (45%)
CREB3L3	NP_115996.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..120		20/128 (16%)
		DUF2207	<169..>266	CDD:303056	45/110 (41%)
		bZIP_CREB3	244..304	CDD:269837	32/59 (54%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	245..274		23/28 (82%)
		coiled coil	246..297	CDD:269837	26/50 (52%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	285..306		7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..408
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..461
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144423
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0709
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288251at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40574
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3645
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.870