DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CrebA and CREB3L2

DIOPT Version :9

Sequence 1:	NP_524087.3	Gene:	CrebA / 39682	FlyBaseID:	FBgn0004396	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_919047.2	Gene:	CREB3L2 / 64764	HGNCID:	23720	Length:	520	Species:	Homo sapiens

Alignment Length:	430	Identity:	147/430 - (34%)
Similarity:	199/430 - (46%)	Gaps:	126/430 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 DPKYLTFHVPPTHATP---------ISRLSSNPALN------------TSVADLTRSSGLQSLQA 154
            |.:.|.:|   ||.:.         :.:|.::|.|:            ||.|.|.::....|| .
Human    26 DGEALMYH---THFSELLDEFSQNVLGQLLNDPFLSEKSVSMEVEPSPTSPAPLIQAEHSYSL-C 86

  Fly   155 HQPHHGSGSSHVVVANLEHFQLPQHLYDNDCSSSVSSLRDGSMSPDICSDIEIDESAIKDEPMSP 219
            .:|...|..:|:..::        ...|::..|     ....:|.|..|      ::||.||::
Human    87 EEPRAQSPFTHITTSD--------SFNDDEVES-----EKWYLSTDFPS------TSIKTEPVT- 131

  Fly   220 DSSCPASPTSQASSSQHQLSLNLAHLQSEMLFEPKHCGLLLTASSNSNNSLIKSQQRQQQILGQD 284
            |...|....|..                          |.:||.|   ..|.|.:...:...|.|
Human   132 DEPPPGLVPSVT--------------------------LTITAIS---TPLEKEEPPLEMNTGVD 167

  Fly   285 N---LLMAKMEIK-SEKQSTSNSSDK----SHAHGYGIPLTPPSSLPSDDSEGNLSPEHLFAPLS 341
            :   .::.|:::: .|.....|.|.|    .|.|   :|.|||||..| ||||:|||.....|.|
Human   168 SSCQTIIPKIKLEPHEVDQFLNFSPKEAPVDHLH---LPPTPPSSHGS-DSEGSLSPNPRLHPFS 228

  Fly   342 -PNATVSISVANPAGGESSVRVSRTAASITRSSSGSASASGSSTSSTVTTTRQPIHTPLISSQPK 405
             |.                          |.|.|.:|..:.|:.||          :||:::..|
Human   229 LPQ--------------------------THSPSRAAPRAPSALSS----------SPLLTAPHK 257

  Fly   406 --GSTGTLLLTEEEKRTLLAEGYPIPQKLPLTKAEEKSLKKIRRKIKNKISAQESRRKKKEYMDQ 468
              || |.|:|||||||||:|||||||.||||:|:|||:||||||||||||||||||||||||||.
Human   258 LQGS-GPLVLTEEEKRTLIAEGYPIPTKLPLSKSEEKALKKIRRKIKNKISAQESRRKKKEYMDS 321

  Fly   469 LERRVEILVTENHDYKKRLEGLEETNANLLSQLHKLQALV 508
            ||::||...|||.:.:|::|.||.||..||.||.|||.||
Human   322 LEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLV 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrebA	NP_524087.3	bZIP_CREB3	452..502	CDD:269837	32/49 (65%)
CrebA	NP_524087.3	coiled coil	452..495	CDD:269837	28/42 (67%)
CREB3L2	NP_919047.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..264		32/109 (29%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	296..325		27/28 (96%)
		bZIP_CREB3	305..348	CDD:269837	28/42 (67%)
		coiled coil	305..348	CDD:269837	28/42 (67%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	336..357		10/20 (50%)
		S1P recognition. /evidence=ECO:0000303\|PubMed:17178827	427..430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144418
Domainoid	1	1.000	88	1.000	Domainoid score	I7931
eggNOG	1	0.900	-	-		E1_KOG0709
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288251at33208
OrthoFinder	1	1.000	-	-		FOG0003444
OrthoInspector	1	1.000	-	-		otm40574
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46004
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3645
SonicParanoid	1	1.000	-	-		X2341
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.840