DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CrebA and Atf6b

DIOPT Version :9

Sequence 1:	NP_524087.3	Gene:	CrebA / 39682	FlyBaseID:	FBgn0004396	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	XP_006256045.1	Gene:	Atf6b / 406169	RGDID:	1303317	Length:	741	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	114/505 - (22%)
Similarity:	186/505 - (36%)	Gaps:	141/505 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PES-LKISPDHDMHDWLFDRDVKDPTVILNDKLIS-----DALLNGTQPIKTEHSYSLSSDVDSL 76
            ||: |.:.....|.:.:...::.|||....|.|:|     ..|.:|...:..|.:.........:
  Rat    35 PENRLMVGGGGKMAELMLLSEIADPTRFFTDNLLSPEDWDSTLYSGLDEVAEEQTQLFRCVEQDV 99

  Fly    77 PDSPKSLQAKIEDMDDECFPAISPKTATNGRVTIDPKYLTFHVPPTHATPI---SRLSSNPALNT 138
            |....||..                    |...|.|:      ||....||   .::.|.|:...
  Rat   100 PFDSSSLDV--------------------GMDVIPPE------PPWDPLPIFPDLQVKSEPSSPC 138

  Fly   139 SVADLTRSSGLQSLQAHQPHHGSGSSHVVVANLEHFQLPQHLYDNDCSSSVSSLRDGSMSPDICS 203
            |      ||.|.|..:|.....|.            |:|:       ...|..::..|::|.:|
  Rat   139 S------SSSLSSESSHLSTEPSS------------QVPR-------VGEVLQVKMESLAPPLC- 177

  Fly   204 DIEIDESAIKDEPMSPDSSCPASPTSQASSSQHQLSLNLAHLQSEMLFEPKHCGLLLTASSNSNN 268
                   .:.|:        ||.|......:....|.:||.:|:::  ||..    .::|.||..
  Rat   178 -------LLGDD--------PAFPFETVQITVGSASDDLADIQTKL--EPAS----PSSSVNSEA 221

  Fly   269 SLIKSQQRQQQILGQDNLLMAKMEIKSEKQSTSNSSDKSHAHGYGIPL--TPPSSLPSDDSEGNL 331
            ||:.:....|.::|::.|     |:|:|..|..           |..|  .|.|||.:.......
  Rat   222 SLLSADSPSQALIGEEVL-----EVKTESPSPP-----------GCLLWDVPASSLGAVQISMGK 270

  Fly   332 SPEHLFAPLSPNATVSISV-ANPAGGESSVRVSRTAASITRSSSGSASASGSSTSSTVTTTRQPI 395
            :|.....||.|...|..:| ..|..|.:|     ||..:.                  ...:||.
  Rat   271 APAPRKPPLQPKPVVLTTVPVPPRAGPAS-----TAVLLQ------------------PLVQQPA 312

  Fly   396 HTPL------ISSQPKGSTGTLLLTEEEKRTLLAEGYPIPQKLPLTKAEEKSLKKIRRKIKNKIS 454
            .:|:      |.:||:|....  ....|:::::..  |:|......:.:.|.||:.:|.|||:.|
  Rat   313 VSPVVLIQGAIRAQPEGPAPA--APRPERKSIVPA--PMPGNACPPEVDAKLLKRQQRMIKNRES 373

  Fly   455 AQESRRKKKEYMDQLERRVEILVTENHD-------YKKRLEGLEETNANL 497
            |.:||||||||:..||.|::.::.:|..       .::|||.|...|:.|
  Rat   374 ACQSRRKKKEYLQGLEARLQAVLADNQQLRRENAALRRRLEALLAENSEL 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrebA	NP_524087.3	bZIP_CREB3	452..502	CDD:269837	20/53 (38%)
CrebA	NP_524087.3	coiled coil	452..495	CDD:269837	18/49 (37%)
Atf6b	XP_006256045.1	PHA03160	<271..337	CDD:165431	18/90 (20%)
		bZIP_ATF6	363..414	CDD:269848	19/50 (38%)
		coiled coil	363..414	CDD:269848	19/50 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338122
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930