DRSC/TRiP Functional Genomics Resources

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Protein Alignment CrebA and Creb3l1

DIOPT Version :10

Sequence 1:NP_524087.3 Gene:CrebA / 39682 FlyBaseID:FBgn0004396 Length:516 Species:Drosophila melanogaster
Sequence 2:NP_036087.2 Gene:Creb3l1 / 26427 MGIID:1347062 Length:520 Species:Mus musculus


Alignment Length:523 Identity:159/523 - (30%)
Similarity:218/523 - (41%) Gaps:205/523 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 DLKDIWDSDL-----DPESLKISPDH---DMHDW---LFDRDVKDPTVILNDK-LISDALLNGTQ 59
            ||.|:.:||.     .||.|    ||   :|.|:   ||.....||  :|::| .:.|..|:...
Mouse    21 DLGDLNESDFLNNAHFPEHL----DHFVENMEDFSNDLFSSFFDDP--VLDEKSALLDMELDSPA 79

  Fly    60 P-IKTEHSYSLSSDVDSLPDSPKSLQAKIEDMDDECFPAISPKTATNGRVTIDPKYLTFHVPPTH 123
            | |:.|||||||.  ||.|.|| .:..|:||         :.:...:|...:..|..:..|....
Mouse    80 PGIQAEHSYSLSG--DSAPQSP-LVPVKMED---------TTQDVEHGAWALGNKLCSIMVKQEQ 132

  Fly   124 A--TPISRLSSNPALNTSVADLTRS-SGLQSL-QAHQPHHGSGSSHVVVANLEHFQLPQHLYDND 184
            :  .|:..|:::.|:..:.|..|.. .||..: :...||...|         |..|||       
Mouse   133 SPELPVDPLAASSAMAAAAAMATPPLLGLSPMPRLPIPHQAPG---------EMTQLP------- 181

  Fly   185 CSSSVSSLRDGSMSPDICSDIEIDESAIKDEPMSPDSSCPASPTSQASSSQHQLSLNLAHLQSEM 249
                                      .||.||  |:                         .|:.
Mouse   182 --------------------------VIKAEP--PE-------------------------MSQF 193

  Fly   250 LFEPKHCGLLLTASSNSNNSLIKSQQRQQQILGQDNLLMAKMEIKSEKQSTSNSSDKSHAHGYGI 314
            |                            ::..:|.:.|                          
Mouse   194 L----------------------------KVTPEDLVQM-------------------------- 204

  Fly   315 PLTPPSSLPSDDSEGNLSPEHLFAPLSPNATVSISVANPAGGESSVR-VSRTAASITRSSSGSAS 378
            |.|||||..| ||:|:.||..| .|.||                 || ::|::.:|:.|      
Mouse   205 PPTPPSSHGS-DSDGSQSPRSL-PPSSP-----------------VRPMARSSTAISTS------ 244

  Fly   379 ASGSSTSSTVTTTRQPIHTPLISSQPK--GSTGTLLLTEEEKRTLLAEGYPIPQKLPLTKAEEKS 441
                               ||:::..|  |::|.|||||||||||:|||||||.||||||||||:
Mouse   245 -------------------PLLTAPHKLQGTSGPLLLTEEEKRTLIAEGYPIPTKLPLTKAEEKA 290

  Fly   442 LKKIRRKIKNKISAQESRRKKKEYMDQLERRVEILVTENHDYKKRLEGLEETNANLLSQLHKLQA 506
            ||::||||||||||||||||||||::.||::||...:||::..|::|.||..|..||.||.|||.
Mouse   291 LKRVRRKIKNKISAQESRRKKKEYVECLEKKVETYTSENNELWKKVETLETANRTLLQQLQKLQT 355

  Fly   507 LVS 509
            ||:
Mouse   356 LVT 358

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CrebANP_524087.3 bZIP_CREB3 452..502 CDD:269837 28/49 (57%)
coiled coil 452..495 CDD:269837 24/42 (57%)
Creb3l1NP_036087.2 Required for transcription activation. /evidence=ECO:0000250|UniProtKB:Q96BA8 1..60 14/42 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 200..259 27/128 (21%)
bZIP_CREB3 291..344 CDD:269837 32/52 (62%)
Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 292..321 23/28 (82%)
coiled coil 293..344 CDD:269837 30/50 (60%)
Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 332..353 9/20 (45%)
S2P recognition. /evidence=ECO:0000250|UniProtKB:Q96BA8 392..395
S1P recognition. /evidence=ECO:0000250|UniProtKB:Q96BA8 423..426
Blue background indicates that the domain is not in the aligned region.

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