DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CrebA and Atf6

DIOPT Version :9

Sequence 1:	NP_524087.3	Gene:	CrebA / 39682	FlyBaseID:	FBgn0004396	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001074773.1	Gene:	Atf6 / 226641	MGIID:	1926157	Length:	656	Species:	Mus musculus

Alignment Length:	367	Identity:	93/367 - (25%)
Similarity:	144/367 - (39%)	Gaps:	78/367 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 HFQLPQHLYDN---------DCSSSVSSLRDGSMSPDICSDIEIDESAIKDEPMSP-DSSCP-AS 226
            ||......|:|         |.....|.|  .|.....|||::.:     .:|:|| .|||. :|
Mouse    35 HFDAAHEAYENNFDHLNFDLDLMPWESDL--WSPGSHFCSDMKAE-----PQPLSPASSSCSISS 92

  Fly   227 PTSQASSSQHQLSLNLAHLQSEMLFEPKHCGLLLTASSNSNNSLIKSQQRQQQILGQDNLLMAKM 291
            |.|..|.|..|      |:..|:                   .|:.|.|....:.|......:.:
Mouse    93 PRSTDSCSSTQ------HVPEEL-------------------DLLSSSQSPLSLYGDSCNSPSSV 132

  Fly   292 E-IKSEKQSTSNSSDKSHAHGYGIPLTPPSSLPSDDSEGNLSPEHLFAPLSPNATVSISVANPAG 355
            | :|.||..|...:...|.      |||...:.. .|:.::.|:.|..|.:|....:.||  ||
Mouse   133 EPLKEEKPVTGPGNKTEHG------LTPKKKIQM-SSKPSVQPKPLLLPAAPKTQTNASV--PA- 187

  Fly   356 GESSVRVSRTAASITRSSSGS-ASASGSSTSSTVTTTRQP----IHTP--LISSQP--KGSTGTL 411
              .::.:....|.:..:...| .|...:.|........||    :.:|  |.|:||  ..:.|..
Mouse   188 --KAIIIQTLPALMPLAKQQSIISIQPAPTKGQTVLLSQPTVVQLQSPAVLSSAQPVLAVTGGAA 250

  Fly   412 LLTEEEKRTLLAE--GYPIPQKLPLTKAEEKS-----------LKKIRRKIKNKISAQESRRKKK 463
            .|.......|.|.  ..|:..||.:||...:|           |::.:|.|||:.||.:||:|||
Mouse   251 QLPNHVVNVLPAPVVSSPVNGKLSVTKPVLQSATRSMGSDIAVLRRQQRMIKNRESACQSRKKKK 315

  Fly   464 EYMDQLERRVEILVTENHDYKKRLEGLEETNANLLSQLHKLQ 505
            |||..||.|::..::||...||....|:.....::|:..:|:
Mouse   316 EYMLGLEARLKAALSENEQLKKENGSLKRQLDEVVSENQRLK 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrebA	NP_524087.3	bZIP_CREB3	452..502	CDD:269837	19/49 (39%)
CrebA	NP_524087.3	coiled coil	452..495	CDD:269837	18/42 (43%)
Atf6	NP_001074773.1	Transcription activation. /evidence=ECO:0000305	1..137		30/133 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..169		28/130 (22%)
		Ribophorin_II	<223..>298	CDD:368624	18/74 (24%)
		Basic motif	295..326		17/30 (57%)
		bZIP_ATF6	296..347	CDD:269848	22/50 (44%)
		coiled coil	296..347	CDD:269848	22/50 (44%)
		Leucine-zipper	335..342		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..429
		Interaction with THBS4. /evidence=ECO:0000269\|PubMed:22682248	455..575
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	632..656
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834551
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930