DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CrebA and Creb3l2

DIOPT Version :9

Sequence 1:	NP_524087.3	Gene:	CrebA / 39682	FlyBaseID:	FBgn0004396	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_848776.2	Gene:	Creb3l2 / 208647	MGIID:	2442695	Length:	521	Species:	Mus musculus

Alignment Length:	397	Identity:	140/397 - (35%)
Similarity:	187/397 - (47%)	Gaps:	98/397 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 ISRLSSNPALN------------TSVADLTRSSGLQSLQAHQPHHGSGSSHVVVANLEHFQLPQH 179
            :.:|.|:|.|:            ||.|.|.::....|| :.:|...|..:|  .|..:.|.
Mouse    48 LGQLLSDPFLSEKSESMEVEPSPTSPAPLIQAEHSYSL-SEEPRTQSPFTH--AATSDSFN---- 105

  Fly   180 LYDNDCSSSVSSLRDGSMSPDICSDIEIDESAIKDEPMSPDSSCPASPTSQASSSQHQLSLNLAH 244
              |.:..|....|           ..|...:.||.||::.:......|:         ::|.:..
Mouse   106 --DEEVESEKWYL-----------STEFPSATIKTEPITEEQPPGLVPS---------VTLTITA 148

  Fly   245 LQSEMLFEPKHCGLLLTASSNSN-NSLIKSQQRQQQILGQDNLLMAKMEIKSEKQSTSNSSDKSH 308
            :.:.  ||.:...|.:.|..:|: .:||..               .|:|.....|..:.|..::.
Mouse   149 ISTP--FEKEESPLDMNAGGDSSCQTLIPK---------------IKLEPHEVDQFLNFSPKEAS 196

  Fly   309 AHGYGIPLTPPSSLPSDDSEGNLSPEHLFAPLSPNATVSISVANPAGGESSVRVSRTAASITRSS 373
            .....:|.||||| .|.||||:|||.....|.|.:...|.:.|.|.|
Mouse   197 VDQLHLPPTPPSS-HSSDSEGSLSPNPRLHPFSLSQAHSPARAMPRG------------------ 242

  Fly   374 SGSASASGSSTSSTVTTTRQPIHTPLISSQPK--GSTGTLLLTEEEKRTLLAEGYPIPQKLPLTK 436
                 .|..|||            ||:::..|  || |.|:|||||||||:|||||||.||||||
Mouse   243 -----PSALSTS------------PLLTAPHKLQGS-GPLVLTEEEKRTLVAEGYPIPTKLPLTK 289

  Fly   437 AEEKSLKKIRRKIKNKISAQESRRKKKEYMDQLERRVEILVTENHDYKKRLEGLEETNANLLSQL 501
            :|||:||||||||||||||||||||||||||.||::||...|||.:.:|::|.||.||..||.||
Mouse   290 SEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQL 354

  Fly   502 HKLQALV 508
            .|||.||
Mouse   355 QKLQTLV 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrebA	NP_524087.3	bZIP_CREB3	452..502	CDD:269837	32/49 (65%)
CrebA	NP_524087.3	coiled coil	452..495	CDD:269837	28/42 (67%)
Creb3l2	NP_848776.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..106		7/31 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	196..264		30/104 (29%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	296..325		27/28 (96%)
		bZIP_CREB3	305..348	CDD:269837	28/42 (67%)
		coiled coil	305..348	CDD:269837	28/42 (67%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	336..357		10/20 (50%)
		S1P recognition. /evidence=ECO:0000250\|UniProtKB:Q70SY1	427..430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834550
Domainoid	1	1.000	100	1.000	Domainoid score	I7006
eggNOG	1	0.900	-	-		E1_KOG0709
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	184	1.000	Inparanoid score	I3940
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288251at33208
OrthoFinder	1	1.000	-	-		FOG0003444
OrthoInspector	1	1.000	-	-		otm42646
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46004
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3645
SonicParanoid	1	1.000	-	-		X2341
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.980