DRSC/TRiP Functional Genomics Resources

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Protein Alignment CrebA and Creb3l2

DIOPT Version :10

Sequence 1:NP_524087.3 Gene:CrebA / 39682 FlyBaseID:FBgn0004396 Length:516 Species:Drosophila melanogaster
Sequence 2:NP_848776.2 Gene:Creb3l2 / 208647 MGIID:2442695 Length:521 Species:Mus musculus


Alignment Length:397 Identity:140/397 - (35%)
Similarity:187/397 - (47%) Gaps:98/397 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 ISRLSSNPALN------------TSVADLTRSSGLQSLQAHQPHHGSGSSHVVVANLEHFQLPQH 179
            :.:|.|:|.|:            ||.|.|.::....|| :.:|...|..:|  .|..:.|.    
Mouse    48 LGQLLSDPFLSEKSESMEVEPSPTSPAPLIQAEHSYSL-SEEPRTQSPFTH--AATSDSFN---- 105

  Fly   180 LYDNDCSSSVSSLRDGSMSPDICSDIEIDESAIKDEPMSPDSSCPASPTSQASSSQHQLSLNLAH 244
              |.:..|....|           ..|...:.||.||::.:......|:         ::|.:..
Mouse   106 --DEEVESEKWYL-----------STEFPSATIKTEPITEEQPPGLVPS---------VTLTITA 148

  Fly   245 LQSEMLFEPKHCGLLLTASSNSN-NSLIKSQQRQQQILGQDNLLMAKMEIKSEKQSTSNSSDKSH 308
            :.:.  ||.:...|.:.|..:|: .:||..               .|:|.....|..:.|..::.
Mouse   149 ISTP--FEKEESPLDMNAGGDSSCQTLIPK---------------IKLEPHEVDQFLNFSPKEAS 196

  Fly   309 AHGYGIPLTPPSSLPSDDSEGNLSPEHLFAPLSPNATVSISVANPAGGESSVRVSRTAASITRSS 373
            .....:|.||||| .|.||||:|||.....|.|.:...|.:.|.|.|                  
Mouse   197 VDQLHLPPTPPSS-HSSDSEGSLSPNPRLHPFSLSQAHSPARAMPRG------------------ 242

  Fly   374 SGSASASGSSTSSTVTTTRQPIHTPLISSQPK--GSTGTLLLTEEEKRTLLAEGYPIPQKLPLTK 436
                 .|..|||            ||:::..|  || |.|:|||||||||:|||||||.||||||
Mouse   243 -----PSALSTS------------PLLTAPHKLQGS-GPLVLTEEEKRTLVAEGYPIPTKLPLTK 289

  Fly   437 AEEKSLKKIRRKIKNKISAQESRRKKKEYMDQLERRVEILVTENHDYKKRLEGLEETNANLLSQL 501
            :|||:||||||||||||||||||||||||||.||::||...|||.:.:|::|.||.||..||.||
Mouse   290 SEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQL 354

  Fly   502 HKLQALV 508
            .|||.||
Mouse   355 QKLQTLV 361

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CrebANP_524087.3 bZIP_CREB3 452..502 CDD:269837 32/49 (65%)
coiled coil 452..495 CDD:269837 28/42 (67%)
Creb3l2NP_848776.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 83..106 7/31 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 196..264 30/104 (29%)
Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 296..325 27/28 (96%)
bZIP_CREB3 305..348 CDD:269837 28/42 (67%)
coiled coil 305..348 CDD:269837 28/42 (67%)
Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 336..357 10/20 (50%)
S1P recognition. /evidence=ECO:0000250|UniProtKB:Q70SY1 427..430
Blue background indicates that the domain is not in the aligned region.

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