DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CrebA and CREB3L4

DIOPT Version :9

Sequence 1:	NP_524087.3	Gene:	CrebA / 39682	FlyBaseID:	FBgn0004396	Length:	516	Species:	Drosophila melanogaster
Sequence 2:	NP_001242907.1	Gene:	CREB3L4 / 148327	HGNCID:	18854	Length:	395	Species:	Homo sapiens

Alignment Length:	415	Identity:	109/415 - (26%)
Similarity:	158/415 - (38%)	Gaps:	167/415 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 LTFHVPPTHATPISRLSSNPALNTSVADLTRSSGLQ----------SLQAHQPHHGSGSSHVVVA 169
            |..|.||.. .|::||              :..|||          .||..:|..
Human    28 LGLHCPPPE-VPVTRL--------------QEQGLQGWKSGGDRGCGLQESEPED---------- 67

  Fly   170 NLEHFQLPQHLYDNDCSSSVSSLRDGSMSPDICSDIEIDESAIKDEPMSPDSSCPASPTSQASSS 234
            .|:.|..|..:|   ||.:         ||.       .:|.|.::|..|||    .|..:|:|
Human    68 FLKLFIDPNEVY---CSEA---------SPG-------SDSGISEDPCHPDS----PPAPRATS- 108

  Fly   235 QHQLSLNLAHLQSEMLFEPKH-CGLL--LTASSNSNNSLIKSQ--QRQQQILGQDNLLMAKMEIK 294
                        |.||:|..: .|.|  :...:..|..||..|  |.....:..|:.:::::..
Human   109 ------------SPMLYEVVYEAGALERMQGETGPNVGLISIQLDQWSPAFMVPDSCMVSELPF- 160

  Fly   295 SEKQSTSNSSDKSHAHGYGIPLTPPSSLPSDDSEGNLSPEHLFAPLSPNATVSISVANPAGGESS 359
                       .:|||          .||   ..|.::|    .|.
Human   161 -----------DAHAH----------ILP---RAGTVAP----VPC------------------- 178

  Fly   360 VRVSRTAASITRSSSGSASASGSSTSSTVTTTRQPIHTPLISSQPKGSTGTLLLTEEEKRTLLAE 424
                                                 |.|:..|      ||.||:||||.|..|
Human   179 -------------------------------------TTLLPCQ------TLFLTDEEKRLLGQE 200

  Fly   425 GYPIPQKLPLTKAEEKSLKKIRRKIKNKISAQESRRKKKEYMDQLERRVEILVTENHDYKKRLEG 489
            |..:|..||||||||:.|||:||||:||.|||:|||:||||:|.||.||.....:|.:.:|:::.
Human   201 GVSLPSHLPLTKAEERVLKKVRRKIRNKQSAQDSRRRKKEYIDGLESRVAACSAQNQELQKKVQE 265

  Fly   490 LEETNANLLSQLHKLQALVSKHNVK 514
            ||..|.:|::||.:||.|:::.:.|
Human   266 LERHNISLVAQLRQLQTLIAQTSNK 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CrebA	NP_524087.3	bZIP_CREB3	452..502	CDD:269837	23/49 (47%)
CrebA	NP_524087.3	coiled coil	452..495	CDD:269837	20/42 (48%)
CREB3L4	NP_001242907.1	PCC	77..>154	CDD:188093	26/112 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..108		10/45 (22%)
		bZIP_CREB3	218..278	CDD:269837	31/59 (53%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	219..248		21/28 (75%)
		coiled coil	220..271	CDD:269837	26/50 (52%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	259..280		7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144422
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0709
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288251at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40574
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840