Protein Alignment CrebA and CREB3

DIOPT Version :10

• Sequence 1: NP_524087.3
• Gene: CrebA / 39682
• FlyBaseID: FBgn0004396
• Length: 516
• Species: Drosophila melanogaster
• Sequence 2: NP_006359.3
• Gene: CREB3 / 10488
• HGNCID: 2347
• Length: 371
• Species: Homo sapiens
• Alignment Length: 202
• Identity: 80/202 - (39%)
• Similarity: 112/202 - (55%)
• Gaps: 19/202 - (9%)

  Fly   318 PPSSLPSDDSEGNLSPEHLFAPLSPNATVSI-SVANP--AGGESSVRVSRTAASITRSSSGSASA 379
            |.|.:|||....:|    |.:.|||.|:::| |.:||  ...:.:..:.|...|:...|. |...
Human    40 PLSEVPSDWEVDDL----LCSLLSPPASLNILSSSNPCLVHHDHTYSLPRETVSMDLESE-SCRK 99

  Fly   380 SGSSTSSTVTTTRQPIHTPLISSQPKGSTGTLLLTEEEKRTLLAEGYPIPQKLPLTKAEEKSLKK 444
            .|        |...|.|...::.|   ....|:||:|||..|..||..:|:.|||||.||:.||:
Human   100 EG--------TQMTPQHMEELAEQ---EIARLVLTDEEKSLLEKEGLILPETLPLTKTEEQILKR 153

  Fly   445 IRRKIKNKISAQESRRKKKEYMDQLERRVEILVTENHDYKKRLEGLEETNANLLSQLHKLQALVS 509
            :||||:||.||||||||||.|:..||.||.....:|.:.:.:::.|||.|.:||.||.||||:|.
Human   154 VRRKIRNKRSAQESRRKKKVYVGGLESRVLKYTAQNMELQNKVQLLEEQNLSLLDQLRKLQAMVI 218

  Fly   510 KHNVKKS 516
            :.:.|.|
Human   219 EISNKTS 225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CrebA	NP_524087.3	bZIP_CREB3	452..502	CDD:269837	24/49 (49%)
		coiled coil	452..495	CDD:269837	20/42 (48%)
CREB3	NP_006359.3	Transcription activation (acidic). /evidence=ECO:0000269|PubMed:10984507	1..92		17/55 (31%)
		LXXLL motif 1	13..17
		LXXLL motif 2	54..58		1/3 (33%)
		HCFC1-binding-motif (HBM)	78..81		0/2 (0%)
		bZIP_CREB3	151..211	CDD:269837	31/59 (53%)
		Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	152..184		22/31 (71%)
		coiled coil	153..204	CDD:269837	25/50 (50%)
		Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	192..213		8/20 (40%)