DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7857 and OTUD6B

DIOPT Version :9

Sequence 1:	NP_648769.2	Gene:	CG7857 / 39671	FlyBaseID:	FBgn0026738	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_057107.4	Gene:	OTUD6B / 51633	HGNCID:	24281	Length:	293	Species:	Homo sapiens

Alignment Length:	316	Identity:	125/316 - (39%)
Similarity:	184/316 - (58%)	Gaps:	55/316 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AELESRLDEVSLEDIGARHRRERKDLQAKLQAMKKNAPKNNKNKRKEFLEEMARLEGELEQRHKA 73
            |.|...|||.  |.:..|||:|:|:||||:|.||...|||:|.:||:..|::|:||.|:||:|:.
Human     3 AVLTEELDEE--EQLLRRHRKEKKELQAKIQGMKNAVPKNDKKRRKQLTEDVAKLEKEMEQKHRE 65

  Fly    74 ELKAAEAMEAPVLVEPVVKEPAEKPETEVTDDDGIEEKEEQLAPN----------QRVSKAQKRR 128
            ||:                      :.::|..   |.|.:.:|.|          .|:|||||||
Human    66 ELE----------------------QLKLTTK---ENKIDSVAVNISNLVLENQPPRISKAQKRR 105

  Fly   129 DKKA-----KEARAREAEIKTELQNAANQPTPKLIELQQITAKLSQRQLSLHNIPSDGDCLYQSI 188
            :|||     :|.|..||||: .|..|.:..:.||.::      |:.|||.:..|||||.|:|::|
Human   106 EKKAALEKEREERIAEAEIE-NLTGARHMESEKLAQI------LAARQLEIKQIPSDGHCMYKAI 163

  Fly   189 RHQLIVN--ALPGHSVQELREETANYVRAHKDSLISYMIHPETGDILNDQQFEQYCHDIAKTHAW 251
            ..||...  ||   :|..||.:||.|:::|.:..:.::.:|.|||:...::|::||.||..|.||
Human   164 EDQLKEKDCAL---TVVALRSQTAEYMQSHVEDFLPFLTNPNTGDMYTPEEFQKYCEDIVNTAAW 225

  Fly   252 GGHIELKAISSLLRVPIEVIQAEGAPTLLGQEEFGGSPLIICYHRHIYQLGAHYNS 307
            ||.:||:|:|.:|:.|||:|||:..|.::| ||:...|||:.|.||.|.||.||||
Human   226 GGQLELRALSHILQTPIEIIQADSPPIIVG-EEYSKKPLILVYMRHAYGLGEHYNS 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7857	NP_648769.2	COG5539	17..307	CDD:227826	119/306 (39%)
CG7857	NP_648769.2	OTU	178..305	CDD:280496	56/128 (44%)
OTUD6B	NP_057107.4	COG5539	18..280	CDD:227826	117/297 (39%)
		Cys-loop. /evidence=ECO:0000250	152..158		5/5 (100%)
		OTU	153..278	CDD:280496	56/128 (44%)
		Variable-loop. /evidence=ECO:0000250	219..229		6/9 (67%)
		His-loop. /evidence=ECO:0000250	267..277		6/9 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5593
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6064
Inparanoid	1	1.050	209	1.000	Inparanoid score	I3684
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54513
OrthoDB	1	1.010	-	-		D1541668at2759
OrthoFinder	1	1.000	-	-		FOG0003029
OrthoInspector	1	1.000	-	-		otm42000
orthoMCL	1	0.900	-	-		OOG6_102788
Panther	1	1.100	-	-	LDO	PTHR12419
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3778
SonicParanoid	1	1.000	-	-		X2018
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	13.010