DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7857 and otud6b

DIOPT Version :9

Sequence 1:	NP_648769.2	Gene:	CG7857 / 39671	FlyBaseID:	FBgn0026738	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_001011269.1	Gene:	otud6b / 496720	XenbaseID:	XB-GENE-985119	Length:	294	Species:	Xenopus tropicalis

Alignment Length:	306	Identity:	124/306 - (40%)
Similarity:	185/306 - (60%)	Gaps:	36/306 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LDEV--SLEDIG--ARHRRERKDLQAKLQAMKKNAPKNNKNKRKEFLEEMARLEGELEQRHKAEL 75
            :||.  :.|:.|  .:||:|::|||||:|:||.:.|||:|.:||:..|::|:||.:|:.|||.||
Frog     1 MDEAEGNSEESGLIKQHRKEKRDLQAKIQSMKNSVPKNDKKRRKQLTEDIAKLEADLDVRHKEEL 65

  Fly    76 KA-AEAMEAPVLVEPVVKEPAEKPETEVTD-DDGIEEKEEQLAPNQRVSKAQKRRDKKA-----K 133
            :| |:....|..|..:.        ..||. |.|.|...:|  |.|  |||||||:|||     :
Frog    66 EAFAQKQPEPTQVSGIT--------NGVTSLDLGNEAPVQQ--PRQ--SKAQKRREKKAAQEKER 118

  Fly   134 EARAREAEIKTELQNAANQPTPKLIELQQITAKLSQRQLSLHNIPSDGDCLYQSIRHQLIV--NA 196
            :.|..||||       ||....:.:|.|::...|::|:|.:..|||||.|:|::|.|||..  |.
Frog   119 DERIAEAEI-------ANLSGARHLESQKLARILAERELQIRQIPSDGHCMYRAIEHQLRERGND 176

  Fly   197 LPGHSVQELREETANYVRAHKDSLISYMIHPETGDILNDQQFEQYCHDIAKTHAWGGHIELKAIS 261
            |   :|..||.:||:|::.|.:..:.::.:..|||:...::|.:||.||..|.||||.:||:|:|
Frog   177 L---TVANLRSQTADYMQNHAEDFLPFLTNSSTGDMYTQEEFLKYCTDIVNTPAWGGQLELRALS 238

  Fly   262 SLLRVPIEVIQAEGAPTLLGQEEFGGSPLIICYHRHIYQLGAHYNS 307
            .:|:..|||||||.:|.::| ||:....:.:.|.||.|.||.||||
Frog   239 HILKTAIEVIQAESSPIVIG-EEYSSKAITLVYMRHAYGLGEHYNS 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7857	NP_648769.2	COG5539	17..307	CDD:227826	121/302 (40%)
CG7857	NP_648769.2	OTU	178..305	CDD:280496	54/128 (42%)
otud6b	NP_001011269.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		21/44 (48%)
		COG5539	4..285	CDD:227826	122/303 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..120		22/64 (34%)
		Cys-loop. /evidence=ECO:0000250	155..161		5/5 (100%)
		OTU	156..281	CDD:280496	54/128 (42%)
		Variable-loop. /evidence=ECO:0000250	222..232		6/9 (67%)
		His-loop. /evidence=ECO:0000250	270..280		6/9 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5904
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6064
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3630
OMA	1	1.010	-	-		QHG54513
OrthoDB	1	1.010	-	-		D1541668at2759
OrthoFinder	1	1.000	-	-		FOG0003029
OrthoInspector	1	1.000	-	-		oto105012
Panther	1	1.100	-	-	LDO	PTHR12419
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3778
SonicParanoid	1	1.000	-	-		X2018
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110