DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7857 and Otud6a

DIOPT Version :9

Sequence 1:	NP_648769.2	Gene:	CG7857 / 39671	FlyBaseID:	FBgn0026738	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_001156663.1	Gene:	Otud6a / 408193	MGIID:	3644685	Length:	290	Species:	Mus musculus

Alignment Length:	303	Identity:	108/303 - (35%)
Similarity:	168/303 - (55%)	Gaps:	41/303 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EVSLEDIGARHRRERKDLQAKLQAMKKNAPKNNKNKRKEFLEEMARLEGELEQRHKAELKAAEAM 81
            |..|:.:..||.||:::|||.:|.:|.:.|||:|.:||:.|.:::|||.|:|||||.||
Mouse     5 EQELQRVIRRHYREKRELQAHIQTLKASVPKNDKGRRKQMLADISRLEAEMEQRHKQEL------ 63

  Fly    82 EAPVLVEPVVKEPAEKPETEVTDDDGIEEKE--EQLAPNQRVSKAQKRRDKKAKEAR-------A 137
                      ::..|.|::.|.......||.  |.:.|  |..|||||||::|.:.|       |
Mouse    64 ----------EKFGENPDSSVDSVTADLEKMNLENMPP--RPPKAQKRRDRRAHQERRHQERMPA 116

  Fly   138 REAEIKTELQNAANQPTPKLIELQQITAKLSQRQLSLHNIPSDGDCLYQSIRHQLIVNALPGHSV 202
            .:||     |.|||:..    |.:::.|.|..:.|.:..||:||.|:|::|:.||:.:.    ::
Mouse   117 AQAE-----QLAANRRE----EEEKVAAILGAKNLEMKTIPADGHCMYRAIQDQLVFSV----TI 168

  Fly   203 QELREETANYVRAHKDSLISYMIHPETGDILNDQQFEQYCHDIAKTHAWGGHIELKAISSLLRVP 267
            :.||..||.|:|.|.|..:.:...||.|:....:.|.:||.||....:|||.:||:|:|.:|:.|
Mouse   169 ESLRYRTAYYMRKHIDDFLPFFTEPEAGNFYTREDFLRYCDDIVHNASWGGQLELRALSHVLQTP 233

  Fly   268 IEVIQAEGAPTLLGQEEFGGSPLIICYHRHIYQLGAHYNSTVP 310
            |||:|| .:||::..||:...|:.:.|..:....|.||||..|
Mouse   234 IEVVQA-NSPTIVIGEEYTRKPVTLVYLHYACDFGEHYNSVKP 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7857	NP_648769.2	COG5539	17..307	CDD:227826	105/298 (35%)
CG7857	NP_648769.2	OTU	178..305	CDD:280496	45/126 (36%)
Otud6a	NP_001156663.1	COG5539	5..272	CDD:227826	105/298 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..117		37/107 (35%)
		Cys-loop. /evidence=ECO:0000250	147..153		4/5 (80%)
		OTU	148..270	CDD:280496	45/126 (36%)
		Variable-loop. /evidence=ECO:0000250	211..221		4/9 (44%)
		His-loop. /evidence=ECO:0000250	259..269		2/9 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835263
Domainoid	1	1.000	120	1.000	Domainoid score	I5740
eggNOG	1	0.900	-	-		E1_COG5539
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	204	1.000	Inparanoid score	I3734
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54513
OrthoDB	1	1.010	-	-		D1541668at2759
OrthoFinder	1	1.000	-	-		FOG0003029
OrthoInspector	1	1.000	-	-		otm44052
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12419
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3778
SonicParanoid	1	1.000	-	-		X2018
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.900