DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7857 and otud6b

DIOPT Version :9

Sequence 1:	NP_648769.2	Gene:	CG7857 / 39671	FlyBaseID:	FBgn0026738	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_956519.1	Gene:	otud6b / 393194	ZFINID:	ZDB-GENE-040426-974	Length:	293	Species:	Danio rerio

Alignment Length:	301	Identity:	126/301 - (41%)
Similarity:	185/301 - (61%)	Gaps:	29/301 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EVSLEDIGARHRRERKDLQAKLQAMKKNAPKNNKNKRKEFLEEMARLEGELEQRHKAELKAAEAM 81
            |.:.|.:..:||:|:||||||:|:||...|||:|.:||:..|::|:||.||.|:|:.|||    :
Zfish     5 ETAEEQLAKQHRKEKKDLQAKIQSMKNAVPKNDKKRRKQLTEDIAKLEAELSQKHENELK----L 65

  Fly    82 EAPVLVEPVVKEPAEKPETEVTDDDGIEEKEEQLAPNQ--RVSKAQKRRDKKA-----KEARARE 139
            :....||.|         ::..|...:...|||..|::  |.|||||||||||     :|.|..|
Zfish    66 QNTSSVEEV---------SDALDSMSVANHEEQSDPSKQSRTSKAQKRRDKKAALEKEREMRIAE 121

  Fly   140 AEIKTELQNAANQPTPKLIELQQITAKLSQRQLSLHNIPSDGDCLYQSIRHQLIVNALPGHSVQE 204
            ||:: .|..:.:|...||.|      ||.:|.|.:..|.|||.|:|:::.|||....| ...::|
Zfish   122 AEVE-NLSGSRHQEGLKLRE------KLVERHLQIKEISSDGHCMYRAVEHQLTERGL-ALGLKE 178

  Fly   205 LREETANYVRAHKDSLISYMIHPETGDILNDQQFEQYCHDIAKTHAWGGHIELKAISSLLRVPIE 269
            ||::||.|:|:|.|..:.::.:|.|||:...::||:||.|:|.|.||||.:||||:|.:|::|||
Zfish   179 LRDQTAQYMRSHADDFMPFLTNPNTGDMYTAEEFEKYCSDVADTAAWGGQLELKALSQVLQLPIE 243

  Fly   270 VIQAEGAPTLLGQEEFGGSPLIICYHRHIYQLGAHYNSTVP 310
            ||||: :|.:...||:....:.:.|.||.|.||.||||..|
Zfish   244 VIQAD-SPCITIGEEYDKPKITLIYMRHAYGLGEHYNSVEP 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7857	NP_648769.2	COG5539	17..307	CDD:227826	123/296 (42%)
CG7857	NP_648769.2	OTU	178..305	CDD:280496	55/126 (44%)
otud6b	NP_956519.1	TMPIT	1..>67	CDD:285135	31/65 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		19/37 (51%)
		COG5539	2..282	CDD:227826	125/298 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..114		25/69 (36%)
		Cys-loop. /evidence=ECO:0000250	152..158		4/5 (80%)
		OTU	154..278	CDD:280496	55/125 (44%)
		Variable-loop. /evidence=ECO:0000250	219..229		6/9 (67%)
		His-loop. /evidence=ECO:0000250	267..277		6/9 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	124	1.000	Domainoid score	I5474
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6064
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3506
OMA	1	1.010	-	-		QHG54513
OrthoDB	1	1.010	-	-		D1541668at2759
OrthoFinder	1	1.000	-	-		FOG0003029
OrthoInspector	1	1.000	-	-		oto38972
orthoMCL	1	0.900	-	-		OOG6_102788
Panther	1	1.100	-	-	LDO	PTHR12419
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3778
SonicParanoid	1	1.000	-	-		X2018
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	14.010