DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7857 and HOOK2

DIOPT Version :9

Sequence 1:	NP_648769.2	Gene:	CG7857 / 39671	FlyBaseID:	FBgn0026738	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_037444.2	Gene:	HOOK2 / 29911	HGNCID:	19885	Length:	719	Species:	Homo sapiens

Alignment Length:	308	Identity:	71/308 - (23%)
Similarity:	127/308 - (41%)	Gaps:	81/308 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AELESRLDEVSLEDIGARHRRERKDLQAKLQAMKKNAPK------NNKNKRKEFLEEMARLEGEL 67
            |:||::             ||:.::||.:.|.....|.|      |.:.|.:...:|..||..|.
Human   360 AQLEAQ-------------RRQVQELQGQRQEEAMKAEKWLFECRNLEEKYESVTKEKERLLAER 411

  Fly    68 EQRHKA--ELKAAEAMEAPVLVEP---VVKEPAEKPETEVTDDDGIE----EKEEQLAPNQRVSK 123
            :...:|  ||:.|:       ::|   ...:|:..|.:...|:...|    |..|.|.   |:..
Human   412 DSLREANEELRCAQ-------LQPRGLTQADPSLDPTSTPVDNLAAEILPAELRETLL---RLQL 466

  Fly   124 AQKRRDKKAKEARAREAEIKTELQNAANQPTPKLIELQQITAKLSQRQLSLHNIPSDGDCLYQSI 188
            ..||..::....|.|:.|::..|:: ||:....| |.|.   :|:|:|||  .:.:..:.|.:::
Human   467 ENKRLCRQEAADRERQEELQRHLED-ANRARHGL-ETQH---RLNQQQLS--ELRAQVEDLQKAL 524

  Fly   189 RHQ----------LIVNALPGHSVQELREETANYVRAHKDSLISYM--IHPETGDILNDQQFEQY 241
            :.|          |:...|..| :|:|.|......|..:     |:  :.|.| |....::.|:.
Human   525 QEQGGKTEDAISILLKRKLEEH-LQKLHEADLELQRKRE-----YIEELEPPT-DSSTARRIEEL 582

  Fly   242 CHDIAKTHAWGGHIELKAISSLLRVPIE----VIQ--------AEGAP 277
            .|::.|..|     :|:|:....|..::    |:|        |.|||
Human   583 QHNLQKKDA-----DLRAMEERYRRYVDKARMVMQTMEPKQRPAAGAP 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7857	NP_648769.2	COG5539	17..307	CDD:227826	68/300 (23%)
CG7857	NP_648769.2	OTU	178..305	CDD:280496	26/124 (21%)
HOOK2	NP_037444.2	Sufficient for interaction with microtubules	1..548		50/218 (23%)
		Required for localization to the centrosome and induction of aggresome formation	1..161
		HOOK	8..706	CDD:283312	71/308 (23%)
		Required for localization to the centrosome and induction of aggresome formation	533..719		24/105 (23%)
		Sufficient for interaction with CNTRL. /evidence=ECO:0000269\|PubMed:17140400	584..719		12/47 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	696..719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000