DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7857 and OTUD1

DIOPT Version :9

Sequence 1:	NP_648769.2	Gene:	CG7857 / 39671	FlyBaseID:	FBgn0026738	Length:	312	Species:	Drosophila melanogaster
Sequence 2:	NP_001138845.1	Gene:	OTUD1 / 220213	HGNCID:	27346	Length:	481	Species:	Homo sapiens

Alignment Length:	196	Identity:	50/196 - (25%)
Similarity:	81/196 - (41%)	Gaps:	45/196 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 PETEVTDDDGIEEKEEQLAPNQRVSKAQKRRDKKAKEARAREAEIKTELQNAANQPTPKLIELQQ 162
            ||.|......||......|....||::..|.:|.|.                      .|.|:::
Human   257 PEAEAPPAGSIEAAPSSAAEPVIVSRSDPRDEKLAL----------------------YLAEVEK 299

  Fly   163 ITAKLSQR-QLSLHNIPSDGDCLYQSIRHQLIVNALPGHSVQELREETANYVRAHKDSLISYMIH 226
            ....|.|| :...|.|| ||:|||::: .:.:......|  :||||:|.:|:..|.|. .|.:|.
Human   300 QDKYLRQRNKYRFHIIP-DGNCLYRAV-SKTVYGDQSLH--RELREQTVHYIADHLDH-FSPLIE 359

  Fly   227 PETGDILNDQQFEQYCHDIAKTHAWGGHIELKAISSLLRVPIEV-----IQAEGAPTL---LGQE 283
            .:.|         ::....|:..||.|:.||.|:..:|.|.|.:     :::....|:   ||.|
Human   360 GDVG---------EFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPE 415

  Fly   284 E 284
            :
Human   416 D 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7857	NP_648769.2	COG5539	17..307	CDD:227826	50/196 (26%)
CG7857	NP_648769.2	OTU	178..305	CDD:280496	32/115 (28%)
OTUD1	NP_001138845.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..60
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..282		7/24 (29%)
		Cys-loop	314..320		4/6 (67%)
		OTU	315..432	CDD:280496	33/116 (28%)
		His-loop	369..379		4/9 (44%)
		Variable-loop	426..431
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910