Protein Alignment CG7857 and OTUD1

DIOPT Version :10

• Sequence 1: NP_648769.2
• Gene: CG7857 / 39671
• FlyBaseID: FBgn0026738
• Length: 312
• Species: Drosophila melanogaster
• Sequence 2: NP_001138845.1
• Gene: OTUD1 / 220213
• HGNCID: 27346
• Length: 481
• Species: Homo sapiens
• Alignment Length: 196
• Identity: 50/196 - (25%)
• Similarity: 81/196 - (41%)
• Gaps: 45/196 - (22%)

  Fly    98 PETEVTDDDGIEEKEEQLAPNQRVSKAQKRRDKKAKEARAREAEIKTELQNAANQPTPKLIELQQ 162
            ||.|......||......|....||::..|.:|.|.                      .|.|:::
Human   257 PEAEAPPAGSIEAAPSSAAEPVIVSRSDPRDEKLAL----------------------YLAEVEK 299

  Fly   163 ITAKLSQR-QLSLHNIPSDGDCLYQSIRHQLIVNALPGHSVQELREETANYVRAHKDSLISYMIH 226
            ....|.|| :...|.|| ||:|||::: .:.:......|  :||||:|.:|:..|.|. .|.:|.
Human   300 QDKYLRQRNKYRFHIIP-DGNCLYRAV-SKTVYGDQSLH--RELREQTVHYIADHLDH-FSPLIE 359

  Fly   227 PETGDILNDQQFEQYCHDIAKTHAWGGHIELKAISSLLRVPIEV-----IQAEGAPTL---LGQE 283
            .:.|         ::....|:..||.|:.||.|:..:|.|.|.:     :::....|:   ||.|
Human   360 GDVG---------EFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPE 415

  Fly   284 E 284
            :
Human   416 D 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7857	NP_648769.2	COG5539	17..307	CDD:227826	50/196 (26%)
		OTU_OTUD6	163..309	CDD:438598	37/131 (28%)
OTUD1	NP_001138845.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	18..60
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..282		7/24 (29%)
		OTU_OTUD1	289..437	CDD:438584	41/164 (25%)
		Cys-loop. /evidence=ECO:0000305|PubMed:23827681	314..320		4/6 (67%)
		His-loop. /evidence=ECO:0000305|PubMed:23827681	369..379		4/9 (44%)
		Variable-loop. /evidence=ECO:0000305|PubMed:23827681	426..431