DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7275 and AT4G28450

DIOPT Version :9

Sequence 1:	NP_648767.1	Gene:	CG7275 / 39669	FlyBaseID:	FBgn0036500	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_567810.5	Gene:	AT4G28450 / 828962	AraportID:	AT4G28450	Length:	452	Species:	Arabidopsis thaliana

Alignment Length:	451	Identity:	192/451 - (42%)
Similarity:	283/451 - (62%)	Gaps:	8/451 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKVKMISRNPDNYVRETKLQQHKMPRNYDPSLHPLEGPREYVRALNATKLDRVFAKPFVCNLSGH 65
            ||:|.:||:.|.|.||......::..|:||||.|:|...||.|||.|.||:::||:|||..:.||
plant     1 MKIKTLSRSVDEYTRERSQDLQRVFHNFDPSLRPMEKAVEYQRALTAAKLEKIFARPFVGAMDGH 65

  Fly    66 RDGVSCFGKHPKQLSTLATGAYDGEVRIWDLANRISSRNFVAHDGFVRGIAYTQNGGRIFTVGDD 130
            ||||||..|:|..|..:.:.:.||::|:||:::|.:...|..|.|.|||:..:.:|..:.:.|.|
plant    66 RDGVSCMAKNPNYLKGIFSASMDGDIRLWDISSRRTVCQFPGHQGAVRGLTASTDGNVLVSCGTD 130

  Fly   131 KTIKVWKAEAPEVGEDEV-------PVNTILSKFGLHGISHNRRDNKFATCGEVCAIWDERHNDP 188
            .|:::|....|.:.:..:       |..|.:.|.....:.|....:.|||.|....||:...:.|
plant   131 CTVRLWNVPRPSLEDSSISSENFIEPSATYVWKNAFWAVDHQFEGDLFATAGAQLDIWNHNRSQP 195

  Fly   189 LKTLKWGVDTLHTISYNPVETSILACCASDRSIILYDQREAQPLRKVVLTMKSNKLAWNPMEAFN 253
            :::.:||.|::.::.:||.|.::||..||||||.:||.|.:...||:::..|:|.:||||||..|
plant   196 VQSFQWGTDSVISVRFNPGEPNLLATSASDRSITIYDLRLSSAARKIIMMTKTNSIAWNPMEPMN 260

  Fly   254 FTVANEDCNLYTFDTRKLQTPLKVHFDHVSAVTDVDYSPTGKEFVSASYDKTIRIYNAHHSHSRD 318
            .|.||||.:.|:||.|||.....||.||||||.|:|:||||:|||:.|||:::||:..:..|||:
plant   261 LTAANEDGSCYSFDGRKLDEAKCVHKDHVSAVMDIDFSPTGREFVTGSYDRSVRIFPYNGGHSRE 325

  Fly   319 IYHTKRMQHVVCVAWSLDNRYVFSGSDEMNVRMWKANASEKLGVIRPRERVNFNYQEALKQKYAA 383
            ||||||||.|.||.:|.|..||.||||:.|:|:|||.|||:||||.|||:....|.||:|.:|..
plant   326 IYHTKRMQRVFCVKYSCDATYVISGSDDTNLRLWKAKASEQLGVILPREQKKHEYNEAVKNRYKH 390

  Fly   384 HPQIKRIARHRQVPRHVLNAQKKMRTVKEKEQVKEANVRKHTKKSKKVPYVSEKKKHVLKE 444
            ..::|||.|||.:|:.:..|...:|||.:.::.|||..:.|:.....|.....|:| ::||
plant   391 LSEVKRIVRHRHLPKPIYKAMGIIRTVNDSKRRKEARRKAHSAPGTVVTAPLRKRK-IIKE 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7275	NP_648767.1	WD40	1..370	CDD:225201	167/375 (45%)
		WD40	62..353	CDD:295369	125/297 (42%)
		WD40 repeat	113..154	CDD:293791	10/47 (21%)
		WD40 repeat	159..193	CDD:293791	8/33 (24%)
		WD40 repeat	200..236	CDD:293791	16/35 (46%)
		WD40 repeat	242..277	CDD:293791	19/34 (56%)
		WD40 repeat	285..327	CDD:293791	25/41 (61%)
		WD40 repeat	328..352	CDD:293791	13/23 (57%)
		Sof1	354..439	CDD:282068	33/84 (39%)
AT4G28450	NP_567810.5	WD40	<63..362	CDD:225201	127/298 (43%)
		WD40	63..360	CDD:238121	125/296 (42%)
		WD40 repeat	69..107	CDD:293791	13/37 (35%)
		WD40 repeat	113..161	CDD:293791	10/47 (21%)
		WD40 repeat	166..200	CDD:293791	8/33 (24%)
		WD40 repeat	207..243	CDD:293791	16/35 (46%)
		WD40 repeat	249..286	CDD:293791	20/36 (56%)
		WD40 repeat	292..334	CDD:293791	25/41 (61%)
		WD40 repeat	335..359	CDD:293791	13/23 (57%)
		Sof1	361..445	CDD:282068	32/83 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	66	1.000	Domainoid score	I3587
eggNOG	1	0.900	-	-		E1_KOG0268
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6430
Inparanoid	1	1.050	396	1.000	Inparanoid score	I483
OMA	1	1.010	-	-		QHG53609
OrthoDB	1	1.010	-	-		D418107at2759
OrthoFinder	1	1.000	-	-		FOG0005198
OrthoInspector	1	1.000	-	-		oto2939
orthoMCL	1	0.900	-	-		OOG6_102358
Panther	1	1.100	-	-	LDO	PTHR22851
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3713
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840