DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7275 and SPBC1A4.07c

DIOPT Version :9

Sequence 1:	NP_648767.1	Gene:	CG7275 / 39669	FlyBaseID:	FBgn0036500	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_595809.1	Gene:	SPBC1A4.07c / 2540796	PomBaseID:	SPBC1A4.07c	Length:	436	Species:	Schizosaccharomyces pombe

Alignment Length:	448	Identity:	197/448 - (43%)
Similarity:	281/448 - (62%)	Gaps:	22/448 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKVKMISRNPDNYVRETKL-QQHKMPRNYDPSLHPLEGPREYVRALNATKLDRVFAKPFVCNLS- 63
            ||||.|:|.    ...|:| .|..:.||.||||||.|..|||.|||||||:||:||.||:..|.
pombe     1 MKVKTITRG----TSLTRLNDQDPVKRNLDPSLHPFERAREYTRALNATKMDRMFAAPFLGQLGR 61

  Fly    64 GHRDGVSCFGKHPKQLSTLATGAYDGEVRIWDLANRISSRNFVAHDGFVRGIAYTQNGGRIFTVG 128
            ||:|||....:..|.|...|:|:.||.|::||.:.|.......||:|.|||:.:: |.|.:.:..
pombe    62 GHQDGVYSLARDTKTLIDCASGSGDGAVKLWDASERCERWTSKAHEGIVRGLVFS-NQGDVLSCA 125

  Fly   129 DDKTIKVWKAEAPEVGEDEVPVNTILSKFGLHGISHNRRDNKFATCGEVCAIWDERHNDPLKTLK 193
            .|:.:.:...:..:|....:..:::|.      |..::..:.|||.||..:|||...:.|:...:
pombe   126 SDRYVYMLNKQDGKVKRSYLGDSSLLD------IDTSKGGDLFATSGENVSIWDYSRDTPVTKFE 184

  Fly   194 WGVDTLHTISYNPVETSILACCASDRSIILYDQREAQPLRKVVLTMKSNKLAWNPMEAFNFTVAN 258
            ||.|||..:.:|..|||:||....||||::||.|.:.||.|::..:::|.::|||||||||...:
pombe   185 WGADTLPVVKFNYTETSVLASAGMDRSIVIYDLRTSSPLTKLITKLRTNSISWNPMEAFNFVAGS 249

  Fly   259 EDCNLYTFDTRKLQTPLKVHFDHVSAVTDVDYSPTGKEFVSASYDKTIRIYNAHHSHSRDIYHTK 323
            ||.|||.:|.|.|:..|.|:.||||||..||:||||:||||.||||||||||....||||:||||
pombe   250 EDHNLYMYDMRNLKRALHVYKDHVSAVMSVDFSPTGQEFVSGSYDKTIRIYNVREGHSRDVYHTK 314

  Fly   324 RMQHVVCVAWSLDNRYVFSGSDEMNVRMWKANASEKLGVIRPRERVNFNYQEALKQKYAAHPQIK 388
            |||.|..|.:|:|.:|:|||||:.|||:|:|.||.:..:...||.....|.::|:::|...|:|:
pombe   315 RMQRVTAVKFSMDAQYIFSGSDDSNVRLWRARASSRASIRSTREENRLKYLDSLRERYKHIPEIR 379

  Fly   389 RIARHRQVPRHVLNAQKKMRTVKEKE----QVKEANVRKHTKKSKKVPYVSEKKKHVL 442
            ||||||.:|.:|    ||...:|.:|    :.:|.|:|:|:||. .|||..|:::||:
pombe   380 RIARHRHLPTNV----KKAAEIKREEINSLKRREENIRRHSKKG-AVPYEKERERHVV 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7275	NP_648767.1	WD40	1..370	CDD:225201	168/370 (45%)
		WD40	62..353	CDD:295369	128/291 (44%)
		WD40 repeat	113..154	CDD:293791	6/40 (15%)
		WD40 repeat	159..193	CDD:293791	10/33 (30%)
		WD40 repeat	200..236	CDD:293791	16/35 (46%)
		WD40 repeat	242..277	CDD:293791	19/34 (56%)
		WD40 repeat	285..327	CDD:293791	31/41 (76%)
		WD40 repeat	328..352	CDD:293791	13/23 (57%)
		Sof1	354..439	CDD:282068	32/88 (36%)
SPBC1A4.07c	NP_595809.1	WD40	<61..346	CDD:225201	128/291 (44%)
		WD40	61..344	CDD:238121	127/289 (44%)
		WD40 repeat	111..146	CDD:293791	6/35 (17%)
		WD40 repeat	152..187	CDD:293791	11/40 (28%)
		WD40 repeat	193..227	CDD:293791	16/33 (48%)
		WD40 repeat	232..269	CDD:293791	19/36 (53%)
		WD40 repeat	277..312	CDD:293791	24/34 (71%)
		Sof1	345..429	CDD:282068	32/88 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	113	1.000	Domainoid score	I1570
eggNOG	1	0.900	-	-		E1_KOG0268
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6430
Inparanoid	1	1.050	376	1.000	Inparanoid score	I429
OMA	1	1.010	-	-		QHG53609
OrthoFinder	1	1.000	-	-		FOG0005198
OrthoInspector	1	1.000	-	-		oto102003
orthoMCL	1	0.900	-	-		OOG6_102358
Panther	1	1.100	-	-	LDO	PTHR22851
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R295
SonicParanoid	1	1.000	-	-		X3713
TreeFam	1	0.960	-	-
	14	13.860