DRSC/TRiP Functional Genomics Resources

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Protein Alignment cocoon and HNRNPDL

DIOPT Version :10

Sequence 1:NP_648764.1 Gene:cocoon / 39665 FlyBaseID:FBgn0036496 Length:318 Species:Drosophila melanogaster
Sequence 2:NP_112740.1 Gene:HNRNPDL / 9987 HGNCID:5037 Length:420 Species:Homo sapiens


Alignment Length:312 Identity:74/312 - (23%)
Similarity:129/312 - (41%) Gaps:60/312 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 NVDTKAVRGVRSNEGRLYSPSEET----GWGEYHYFCVFPKKNKRQSEDNLENSTAKTKRTEAHL 104
            ::...|.....:...|.:.|::.:    ...||.....|.:.:|..:..|.::..          
Human    94 SIQRSAAAAAATRTARQHPPADSSVTMEDMNEYSNIEEFAEGSKINASKNQQDDG---------- 148

  Fly   105 RCFDLIVLGLSYNTTEQDLREYFETYGDVVKAEIKKDTRSGHSKGFGFVRF---GSYDVQMHVLS 166
               .:.:.|||::|:::||.||...:|:||...||.|..:|.|:|||||.|   .|.|..:.:  
Human   149 ---KMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLEL-- 208

  Fly   167 KRHSIDGRWCEVKVPASRGMGNQEPGKVFVGRCTEDIEADDLREYFSKFGEVIDVFIP-----KP 226
            |.|.:||:..:.| .|....|.:.|.|||||..:.|...:.::|||..|||:.::.:|     ..
Human   209 KEHKLDGKLIDPK-RAKALKGKEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNE 272

  Fly   227 FRAFSFVTFLDPY-VPRVVCGEKHIIKGVSVHVSTADKKNVQNKNQLFQT--------------- 275
            .|.|.|:|:.|.. |.:::....|.|......:..|..|.|..:.|..|.               
Human   273 RRGFCFITYTDEEPVKKLLESRYHQIGSGKCEIKVAQPKEVYRQQQQQQKGGRGAAAGGRGGTRG 337

  Fly   276 ------NNYNNLDNNFKMQPANNFRM----------HPANNFSMHSFNPHGY 311
                  .|:|...||:..|...|:..          :...:::.:::..:||
Human   338 RGRGQGQNWNQGFNNYYDQGYGNYNSAYGGDQNYSGYGGYDYTGYNYGNYGY 389

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cocoonNP_648764.1 TDP43_N 3..78 CDD:465833 5/37 (14%)
RRM1_TDP43 108..181 CDD:409760 29/75 (39%)
RRM2_TDP43 193..262 CDD:409761 21/74 (28%)
HNRNPDLNP_112740.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..83
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 96..120 3/23 (13%)
RRM1_hnRPDL 149..224 CDD:410152 29/77 (38%)
RRM2_hnRPDL 234..308 CDD:409998 21/73 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 313..348 4/34 (12%)
Necessary for interaction with TNPO1. /evidence=ECO:0000269|PubMed:9524220 342..420 8/48 (17%)
Necessary for its nuclear import and export 396..420
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..420
Blue background indicates that the domain is not in the aligned region.

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