Protein Alignment cocoon and RBM23

DIOPT Version :10

• Sequence 1: NP_648764.1
• Gene: cocoon / 39665
• FlyBaseID: FBgn0036496
• Length: 318
• Species: Drosophila melanogaster
• Sequence 2: NP_001339693.1
• Gene: RBM23 / 55147
• HGNCID: 20155
• Length: 483
• Species: Homo sapiens
• Alignment Length: 241
• Identity: 53/241 - (21%)
• Similarity: 81/241 - (33%)
• Gaps: 78/241 - (32%)

  Fly    36 ESSGLQYRNVDTKAVRGVRSNEGRLYSPSEETGWGEYHYFCVFPKKNKRQSEDNL--ENSTAKTK 98
            ||....:|..|....|......|..|..|:...:.|        |...|:..|||  |...|:|
Human   156 ESRSRDHRREDRVHYRSPPLATGYRYGHSKSPHFRE--------KSPVREPVDNLSPEERDART- 211

  Fly    99 RTEAHLRCFDLIVLGLSYNTTEQDLREYFETYGDVVKAEIKKDTRSGHSKGFGFVRFGSYDVQMH 163
                      :..:.|:.....:||.::|...|.|....|..|..|..|||..:|.|
Human   212 ----------VFCMQLAARIRPRDLEDFFSAVGKVRDVRIISDRNSRRSKGIAYVEF-------- 258

  Fly   164 VLSKRHSIDGRWCEVK-VPASRGM-------------------------------GNQEPGKVFV 196
                        ||:: ||.:.|:                               ||..|.:::|
Human   259 ------------CEIQSVPLAIGLTGQRLLGVPIIVQASQAEKNRLAAMANNLQKGNGGPMRLYV 311

  Fly   197 GRCTEDIEADDLREYFSKFGEVIDVFIPKP-----FRAFSFVTFLD 237
            |....:|..|.||..|..||::.::.:.|.     .:.:.|:||.|
Human   312 GSLHFNITEDMLRGIFEPFGKIDNIVLMKDSDTGRSKGYGFITFSD 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cocoon	NP_648764.1	TDP43_N	3..78	CDD:465833	9/41 (22%)
		RRM1_TDP43	108..181	CDD:409760	16/73 (22%)
		RRM2_TDP43	193..262	CDD:409761	14/50 (28%)
RBM23	NP_001339693.1	SF-CC1	143..482	CDD:273721	53/241 (22%)