DRSC/TRiP Functional Genomics Resources

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Protein Alignment cocoon and hnrnpa1

DIOPT Version :10

Sequence 1:NP_648764.1 Gene:cocoon / 39665 FlyBaseID:FBgn0036496 Length:318 Species:Drosophila melanogaster
Sequence 2:XP_012812298.1 Gene:hnrnpa1 / 496507 XenbaseID:XB-GENE-493963 Length:362 Species:Xenopus tropicalis


Alignment Length:234 Identity:72/234 - (30%)
Similarity:104/234 - (44%) Gaps:33/234 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   109 LIVLGLSYNTTEQDLREYFETYGDVVKAEIKKDTRSGHSKGFGFVRFGSYD-VQMHVLSKRHSID 172
            |.:.|||:.||::.|||:||.:|.:....:.:|..|..|:|||||.:.|.| |...:.::.|.:|
 Frog    16 LFIGGLSFETTDESLREHFEQWGTLTDCVVMRDPNSKRSRGFGFVTYSSTDEVDAAMSARPHKVD 80

  Fly   173 GRWCEVKVPASRGMGNQEPG------KVFVGRCTEDIEADDLREYFSKFG--EVIDVFIPK---P 226
            ||..|.|...|| ..:..||      |:|||...||.|...|||||.::|  |||::...:   .
 Frog    81 GRVVEPKRAVSR-EDSSRPGAHLTVKKIFVGGIKEDTEEHHLREYFEQYGKIEVIEIMTDRGSGK 144

  Fly   227 FRAFSFVTFLD-PYVPRVVCGEKHIIKGVSVHVSTADKK-----------------NVQNKNQLF 273
            .|.|:||||.| ..|.::|..:.|.:...:..|..|..|                 |...:.. |
 Frog   145 KRGFAFVTFEDHDSVDKIVIQKYHTVNNHNCEVRKALSKQEMASVSGSQRGRGGSGNFSGRGG-F 208

  Fly   274 QTNNYNNLDNNFKMQPANNFRMHPANNFSMHSF-NPHGY 311
            ..:|:.....||.......|..........:.| |..||
 Frog   209 GNDNFGGRGGNFSSNRGGGFGNRGYGGDGYNGFGNDGGY 247

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cocoonNP_648764.1 TDP43_N 3..78 CDD:465833
RRM1_TDP43 108..181 CDD:409760 29/72 (40%)
RRM2_TDP43 193..262 CDD:409761 27/74 (36%)
hnrnpa1XP_012812298.1 RRM1_hnRNPA1 12..92 CDD:410154 29/75 (39%)
RRM_SF 105..184 CDD:473069 28/78 (36%)
HnRNPA1 <315..>334 CDD:463312
Blue background indicates that the domain is not in the aligned region.

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