Protein Alignment cocoon and NCL

DIOPT Version :10

• Sequence 1: NP_648764.1
• Gene: cocoon / 39665
• FlyBaseID: FBgn0036496
• Length: 318
• Species: Drosophila melanogaster
• Sequence 2: NP_005372.2
• Gene: NCL / 4691
• HGNCID: 7667
• Length: 710
• Species: Homo sapiens
• Alignment Length: 268
• Identity: 65/268 - (24%)
• Similarity: 113/268 - (42%)
• Gaps: 75/268 - (27%)

  Fly     7 SEKEGDE--------PIELPAEEDGTLLLSTLQAQFPESSGLQYRNVDTKAVRGVRSNEGRLYSP 63
            |:||.|.        |.::..:|        |:..|.:::.::..:.|.|: :|:...|.:..:.
Human   386 SKKERDARTLLAKNLPYKVTQDE--------LKEVFEDAAEIRLVSKDGKS-KGIAYIEFKTEAD 441

  Fly    64 SEETGWGEYHYFCVFPKK----------------NKRQSED--NLENST----AKTKRTEAHLRC 106
            :|:|          |.:|                .|.|::|  ..:|||    :||
Human   442 AEKT----------FEEKQGTEIDGRSISLYYTGEKGQNQDYRGGKNSTWSGESKT--------- 487

  Fly   107 FDLIVLGLSYNTTEQDLREYFETYGDVVKAEIKK--DTRSGHSKGFGFVRFGSYDVQMHVLS--K 167
              |::..|||:.||:.|:|.||      ||...|  ..::|.|||:.|:.|.|::.....|:  .
Human   488 --LVLSNLSYSATEETLQEVFE------KATFIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCN 544

  Fly   168 RHSIDGRWCEVKVPASRGMGN--QEPGK-VFVGRCTEDIEADDLREYF--SKFGEVIDVFIPKPF 227
            :..|:||...:::...||..|  .:|.| :||...:||...:.|:|.|  |....::........
Human   545 KREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSVRARIVTDRETGSS 609

  Fly   228 RAFSFVTF 235
            :.|.||.|
Human   610 KGFGFVDF 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cocoon	NP_648764.1	TDP43_N	3..78	CDD:465833	14/78 (18%)
		RRM1_TDP43	108..181	CDD:409760	24/76 (32%)
		RRM2_TDP43	193..262	CDD:409761	13/46 (28%)
NCL	NP_005372.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..303
		8 X 8 AA tandem repeats of X-T-P-X-K-K-X-X	58..135
		RRM1_NCL	307..381	CDD:409837
		RRM2_NCL	390..465	CDD:409838	13/93 (14%)
		RRM3_NCL	485..557	CDD:409839	26/88 (30%)
		RRM4_NCL	572..649	CDD:409840	13/46 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	640..710