DRSC/TRiP Functional Genomics Resources

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Protein Alignment cocoon and MSI1

DIOPT Version :10

Sequence 1:NP_648764.1 Gene:cocoon / 39665 FlyBaseID:FBgn0036496 Length:318 Species:Drosophila melanogaster
Sequence 2:NP_002433.1 Gene:MSI1 / 4440 HGNCID:7330 Length:362 Species:Homo sapiens


Alignment Length:173 Identity:53/173 - (30%)
Similarity:82/173 - (47%) Gaps:16/173 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   109 LIVLGLSYNTTEQDLREYFETYGDVVKAEIKKDTRSGHSKGFGFVRF-GSYDVQMHVLSKRHSID 172
            :.:.|||:.||::.|||||..:|:|.:..:.:|..:..|:|||||.| ....|...:...||.:|
Human    22 MFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQSRHELD 86

  Fly   173 GRWCEVKVPASRGMGNQEP------GKVFVGRCTEDIEADDLREYFSKFGEVIDVFI-----PKP 226
            .:..:.||...|   ..:|      .|:|||..:.:...:|:::||.:||:|.|..:     ...
Human    87 SKTIDPKVAFPR---RAQPKMVTRTKKIFVGGLSVNTTVEDVKQYFEQFGKVDDAMLMFDKTTNR 148

  Fly   227 FRAFSFVTFLDPYVPRVVCG-EKHIIKGVSVHVSTADKKNVQN 268
            .|.|.||||....:...||. ..|.|....|....|..|.|.:
Human   149 HRGFGFVTFESEDIVEKVCEIHFHEINNKMVECKKAQPKEVMS 191

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cocoonNP_648764.1 TDP43_N 3..78 CDD:465833
RRM1_TDP43 108..181 CDD:409760 25/72 (35%)
RRM2_TDP43 193..262 CDD:409761 22/74 (30%)
MSI1NP_002433.1 RRM1_MSI 21..96 CDD:409990 26/73 (36%)
PABP-1234 <32..339 CDD:130689 49/163 (30%)
RRM2_MSI 110..183 CDD:240769 22/72 (31%)
Blue background indicates that the domain is not in the aligned region.

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