DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cocoon and tardbp

DIOPT Version :9

Sequence 1:	NP_001261874.1	Gene:	cocoon / 39665	FlyBaseID:	FBgn0036496	Length:	318	Species:	Drosophila melanogaster
Sequence 2:	XP_012821726.1	Gene:	tardbp / 394651	XenbaseID:	XB-GENE-974453	Length:	418	Species:	Xenopus tropicalis

Alignment Length:	328	Identity:	163/328 - (49%)
Similarity:	215/328 - (65%)	Gaps:	31/328 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVFVHVSEKEGDEPIELPAEEDGTLLLSTLQAQFPESSGLQYRNVDTKAVRGVRSNEGRLYSPSE 65
            |.::.|:|.|.:||:|:|:|:|||:||||:.||||.:.||:|||...:.:||||..||.|::|
Frog    12 MEYIRVAEDENEEPMEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVNQCMRGVRLVEGILHAP-- 74

  Fly    66 ETGWGEYHYFCVFPKKNKRQSEDNLENSTAKTKRTEAHLRCFDLIVLGLSYNTTEQDLREYFETY 130
            |.|||...|...:||.|||:.::...:|..|.||  |..:..|||||||.:.||||||::||.|:
Frog    75 ENGWGNLVYVVNYPKDNKRKMDETDASSAVKIKR--AVTKTSDLIVLGLPWKTTEQDLKDYFSTF 137

  Fly   131 GDVVKAEIKKDTRSGHSKGFGFVRFGSYDVQMHVLSKRHSIDGRWCEVKVPASRGMGNQEP---G 192
            |:|:..::|||.::|||||||||||..|:.|:.|:|:||.||||||:.|:|.|:  ...||   .
Frog   138 GEVIMVQVKKDAKTGHSKGFGFVRFADYETQVKVMSQRHMIDGRWCDCKLPNSK--SPDEPMRSR 200

  Fly   193 KVFVGRCTEDIEADDLREYFSKFGEVIDVFIPKPFRAFSFVTFLDPYVPRVVCGEKHIIKGVSVH 257
            ||||||||||:.|::||::||::|||:|||||||||||:||||.|..|.:.:|||..||||||||
Frog   201 KVFVGRCTEDMSAEELRQFFSQYGEVVDVFIPKPFRAFAFVTFADDQVAQSLCGEDLIIKGVSVH 265

  Fly   258 VSTADKKNVQNKNQL----------FQTNNYNN-------LDNNFKMQPANNFRMHPANNFSMHS 305
            ||||:.|: .|..||          |....|.|       |.||    ...|.......||...|
Frog   266 VSTAEPKH-NNNRQLERGGRFPGPSFGNQGYPNSRPSSGALGNN----QGGNMGGGGGMNFGAFS 325

  Fly   306 FNP 308
            .||
Frog   326 INP 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cocoon	NP_001261874.1	RRM1_TDP43	108..184	CDD:240767	46/75 (61%)
cocoon	NP_001261874.1	RRM2_TDP43	193..262	CDD:240768	49/68 (72%)
tardbp	XP_012821726.1	RRM	<87..232	CDD:223796	80/148 (54%)
		RRM1_TDP43	115..191	CDD:240767	46/75 (61%)
		RRM	<190..>299	CDD:223796	60/111 (54%)
		RRM2_TDP43	200..270	CDD:240768	49/69 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I7885
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	352	1.000	Inparanoid score	I2215
OMA	1	1.010	-	-		QHG48344
OrthoDB	1	1.010	-	-		D390211at33208
OrthoFinder	1	1.000	-	-		FOG0005498
OrthoInspector	1	1.000	-	-		otm48016
Panther	1	1.100	-	-	O	PTHR48033
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3916
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080