DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cocoon and TBPH

DIOPT Version :9

Sequence 1:	NP_001261874.1	Gene:	cocoon / 39665	FlyBaseID:	FBgn0036496	Length:	318	Species:	Drosophila melanogaster
Sequence 2:	NP_001163280.1	Gene:	TBPH / 37781	FlyBaseID:	FBgn0025790	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	314	Identity:	229/314 - (72%)
Similarity:	256/314 - (81%)	Gaps:	17/314 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVFVHVSEKEGDEPIELPAEEDGTLLLSTLQAQFPESSGLQYRNVDTKAVRGVRSNEGRLYSPSE 65
            |.||.|||:||||||||||||||||||||||||||.|.||:|||:|||||||||||||||:.||.
  Fly     1 MDFVQVSEEEGDEPIELPAEEDGTLLLSTLQAQFPGSCGLKYRNLDTKAVRGVRSNEGRLFPPSV 65

  Fly    66 ETGWGEYHYFCVFPKKNKRQSEDNLENSTAKTKRTEAHLRCFDLIVLGLSYNTTEQDLREYFETY 130
            |:|||||.|||||||:|||:|:||||||||||||.|..|||.|||||||.:.|||:.||||||||
  Fly    66 ESGWGEYAYFCVFPKENKRKSDDNLENSTAKTKRIETRLRCTDLIVLGLPWKTTEESLREYFETY 130

  Fly   131 GDVVKAEIKKDTRSGHSKGFGFVRFGSYDVQMHVLSKRHSIDGRWCEVKVPASRGMGNQEPGKVF 195
            |:|:.|:|||||:||.|||||||||||||.||.||:.||.|||||||||||.|:|||:|.|.|||
  Fly   131 GEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLTNRHLIDGRWCEVKVPNSKGMGHQVPCKVF 195

  Fly   196 VGRCTEDIEADDLREYFSKFGEVIDVFIPKPFRAFSFVTFLDPYVPRVVCGEKHIIKGVSVHVST 260
            ||||||||.:|||||||||||||.|||||:|||||||||||||.|.:.:|||.|||||||||||.
  Fly   196 VGRCTEDINSDDLREYFSKFGEVTDVFIPRPFRAFSFVTFLDPDVAQSLCGEDHIIKGVSVHVSN 260

  Fly   261 ADKKNVQNKNQLFQTNNYNNLDNNFKMQPANNFRMHPANNFSMHSFNPHGYQMN 314
            |..|..||:||..|:.|||:                 ||:|.|||::|.|..||
  Fly   261 AAPKAEQNRNQQVQSYNYNS-----------------ANSFGMHSYHPQGNHMN 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cocoon	NP_001261874.1	RRM1_TDP43	108..184	CDD:240767	58/75 (77%)
cocoon	NP_001261874.1	RRM2_TDP43	193..262	CDD:240768	57/68 (84%)
TBPH	NP_001163280.1	RRM1_TDP43	108..184	CDD:240767	58/75 (77%)
TBPH	NP_001163280.1	RRM2_TDP43	192..261	CDD:240768	57/68 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472756
Domainoid	1	1.000	84	1.000	Domainoid score	I8177
eggNOG	1	0.900	-	-		E1_28HBV
Homologene	1	1.000	-	-		H134087
Inparanoid	1	1.050	332	1.000	Inparanoid score	I2410
Isobase	1	0.950	-	0	Normalized mean entropy	S1962
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D390211at33208
OrthoFinder	1	1.000	-	-		FOG0005498
OrthoInspector	1	1.000	-	-		mtm6337
orthoMCL	1	0.900	-	-		OOG6_105367
Panther	1	1.100	-	-	P	PTHR48033
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3916
	13	12.750