Protein Alignment cocoon and HNRNPAB

DIOPT Version :10

• Sequence 1: NP_648764.1
• Gene: cocoon / 39665
• FlyBaseID: FBgn0036496
• Length: 318
• Species: Drosophila melanogaster
• Sequence 2: NP_112556.2
• Gene: HNRNPAB / 3182
• HGNCID: 5034
• Length: 332
• Species: Homo sapiens
• Alignment Length: 336
• Identity: 83/336 - (24%)
• Similarity: 143/336 - (42%)
• Gaps: 66/336 - (19%)

  Fly     6 VSEKEGDEPIELP-AEEDGTLLLSTLQAQFPESSGLQYRNVDTKAVRGVRSNEGRLYSPSEETGW 69
            :||...::|:|.. |.|:|...:.  :.:.|..:|       |.|..|.   .|...:|
Human     1 MSEAGEEQPMETTGATENGHEAVP--EGESPAGAG-------TGAAAGA---GGATAAP------ 47

  Fly    70 GEYHYFCVFPKKNKRQSEDNLENSTAKTKRTEAHLRCFDLIVLGLSYNTTEQDLREYFETYGDVV 134
                     |..|:..:|.:..|:   :|..|...:.|   |.|||::|:::||::||..:|:||
Human    48 ---------PSGNQNGAEGDQINA---SKNEEDAGKMF---VGGLSWDTSKKDLKDYFTKFGEVV 97

  Fly   135 KAEIKKDTRSGHSKGFGFVRF-GSYDVQMHVLSKRHSIDGRWCEVKVPASRGMGNQEPGKVFVGR 198
            ...||.|..:|.|:||||:.| .:..|:..:..|.|.:|||..:.|  .:..|......|:|||.
Human    98 DCTIKMDPNTGRSRGFGFILFKDAASVEKVLDQKEHRLDGRVIDPK--KAMAMKKDPVKKIFVGG 160

  Fly   199 CTEDIEADDLREYFSKFGEVIDVFIP-----KPFRAFSFVTFLDPYVPRVVCGEK-HIIKGVSVH 257
            ...:...:.:||||.:|||:..:.:|     ...|.|.|:||.:....:.|..:| |.:.|....
Human   161 LNPEATEEKIREYFGEFGEIEAIELPMDPKLNKRRGFVFITFKEEEPVKKVLEKKFHTVSGSKCE 225

  Fly   258 VSTADKKNVQNKNQL----------------------FQTNNYNNLDNNFKMQPANNFRMHPANN 300
            :..|..|.|..:.|.                      .|:.::|....|:..| ...::......
Human   226 IKVAQPKEVYQQQQYGSGGRGNRNRGNRGSGGGGGGGGQSQSWNQGYGNYWNQ-GYGYQQGYGPG 289

  Fly   301 FSMHSFNPHGY 311
            :..:.::|:||
Human   290 YGGYDYSPYGY 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cocoon	NP_648764.1	TDP43_N	3..78	CDD:465833	14/72 (19%)
		RRM1_TDP43	108..181	CDD:409760	29/73 (40%)
		RRM2_TDP43	193..262	CDD:409761	21/74 (28%)
HNRNPAB	NP_112556.2	CBFNT	1..70	CDD:311868	20/98 (20%)
		RRM1_hnRNPAB	66..145	CDD:410151	31/83 (37%)
		RRM2_hnRNPAB	150..229	CDD:409997	21/78 (27%)