Protein Alignment cocoon and HNRNPA2B1

DIOPT Version :10

• Sequence 1: NP_648764.1
• Gene: cocoon / 39665
• FlyBaseID: FBgn0036496
• Length: 318
• Species: Drosophila melanogaster
• Sequence 2: NP_112533.1
• Gene: HNRNPA2B1 / 3181
• HGNCID: 5033
• Length: 353
• Species: Homo sapiens
• Alignment Length: 233
• Identity: 75/233 - (32%)
• Similarity: 111/233 - (47%)
• Gaps: 31/233 - (13%)

  Fly    87 EDNLENSTAKTKRTEAHLRCFDLIVLGLSYNTTEQDLREYFETYGDVVKAEIKKDTRSGHSKGFG 151
            |..||....:.|:.|.. :...|.:.|||:.|||:.||.|:|.:|.:....:.:|..|..|:|||
Human     2 EKTLETVPLERKKREKE-QFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFG 65

  Fly   152 FVRFGSY-DVQMHVLSKRHSIDGRWCEVKVPASRGMGNQEPG---------KVFVGRCTEDIEAD 206
            ||.|.|. :|...:.::.||||||..|.|    |.:..:|.|         |:|||...||.|..
Human    66 FVTFSSMAEVDAAMAARPHSIDGRVVEPK----RAVAREESGKPGAHVTVKKLFVGGIKEDTEEH 126

  Fly   207 DLREYFSKFGEV--IDVFIPKPF---RAFSFVTF--LDPYVPRVVCGEKHIIKGVSVHVSTADKK 264
            .||:||.::|::  |::...:..   |.|.||||  .|| |.::|..:.|.|.|.:..|..|..:
Human   127 HLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDP-VDKIVLQKYHTINGHNAEVRKALSR 190

  Fly   265 NVQNKNQLFQTNNYNNL--------DNNFKMQPANNFR 294
            ....:.|..::....|.        ..||...|.:|||
Human   191 QEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFR 228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cocoon	NP_648764.1	TDP43_N	3..78	CDD:465833
		RRM1_TDP43	108..181	CDD:409760	31/73 (42%)
		RRM2_TDP43	193..262	CDD:409761	27/75 (36%)
HNRNPA2B1	NP_112533.1	Nuclear localization signal. /evidence=ECO:0000255	9..15		1/5 (20%)
		RRM1_hnRNPA2B1	19..99	CDD:410155	32/83 (39%)
		RRM2_hnRNPA2B1	112..191	CDD:409995	28/79 (35%)
		Disordered. /evidence=ECO:0000269|PubMed:26544936	193..353		8/36 (22%)
		HnRNPA1	302..326	CDD:463312
		Nuclear targeting sequence. /evidence=ECO:0000250	308..347