DRSC/TRiP Functional Genomics Resources

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Protein Alignment cocoon and MSI2

DIOPT Version :10

Sequence 1:NP_648764.1 Gene:cocoon / 39665 FlyBaseID:FBgn0036496 Length:318 Species:Drosophila melanogaster
Sequence 2:XP_005257072.1 Gene:MSI2 / 124540 HGNCID:18585 Length:346 Species:Homo sapiens


Alignment Length:173 Identity:49/173 - (28%)
Similarity:81/173 - (46%) Gaps:24/173 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   109 LIVLGLSYNTTEQDLREYFETYGDVVKAEIKKDTRSGHSKGFGFVRFGSYDVQMHVLSK-RHSID 172
            :.:.|||:.|:...||:||..:|::.:..:.:|..:..|:|||||.|........||.: .|.:|
Human    23 MFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELD 87

  Fly   173 GRWCEVKVPASRGMGNQEP------GKVFVGRCTEDIEADDLREYFSKFGEVIDVFI-----PKP 226
            .:..:.||...|   ..:|      .|:|||..:.:...:|:::||.:||:|.|..:     ...
Human    88 SKTIDPKVAFPR---RAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNR 149

  Fly   227 FRAFSFVTFLDPYVPRVVCGEKHIIKGVSVHVSTADKKNVQNK 269
            .|.|.||||.:..|...||         .:|....:.|.|:.|
Human   150 HRGFGFVTFENEDVVEKVC---------EIHFHEINNKMVECK 183

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cocoonNP_648764.1 TDP43_N 3..78 CDD:465833
RRM1_TDP43 108..181 CDD:409760 22/72 (31%)
RRM2_TDP43 193..262 CDD:409761 21/73 (29%)
MSI2XP_005257072.1 RRM1_MSI2 17..109 CDD:410153 25/88 (28%)
RRM2_MSI 111..184 CDD:240769 24/82 (29%)
Blue background indicates that the domain is not in the aligned region.

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