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Protein Alignment Toll-6 and LGI1

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_005088.1	Gene:	LGI1 / 9211	HGNCID:	6572	Length:	557	Species:	Homo sapiens

Alignment Length:	653	Identity:	132/653 - (20%)
Similarity:	216/653 - (33%)	Gaps:	225/653 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   472 YVLSLLSLDNNALI---GVHP-----DAFRNCSALQDLNLNGNQL-KTVPLALRNMRHLRT--VD 525
            |.|.|||    ||:   |..|     .|...|:....|..|...: :|||..:.::..:|:  .:
Human    21 YFLCLLS----ALLLTEGKKPAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTE 81

  Fly   526 LGE----------------NMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNL 574
            :.|                |...|:.|.||.||.:|..|.:..|.:::|:.||||.|.:|..|:|
Human    82 ISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSL 146

  Fly   575 ARNRIAVVEPGAFEMTSSIQAVRLDGNELN-DINGLFSNMPSLLWLNISDNRLESFDYGHVPSTL 638
            |.|.:..:....|:...|:..|.|.||..| |.        .|.||      :|..  ||..:|:
Human   147 ANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDC--------KLKWL------VEWL--GHTNATV 195

  Fly   639 QWLDLH--------KNRLSSLSNR--------FGLDSELKLQTLDVSFNQLQRIGPSSIPNSIEL 687
            :  |::        |.:::|||::        |....:|..|:|.:
Human   196 E--DIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSI------------------- 239

  Fly   688 LFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDC 752
                         |||.          |.|.                     |:.:...|||..|
Human   240 -------------DTFS----------YLND---------------------EYVVIAQPFTGKC 260

  Fly   753 -NIDWLQKINHI--TSRQYPRIMDLETIYCKLLNNRERAYIPLIEAE---PKHFLCTYKTHCFAV 811
             .::|    :|:  |.|.|..|....|:.||.:....:.|:  |.|:   ..|.   ||...||.
Human   261 IFLEW----DHVEKTFRNYDNITGTSTVVCKPIVIETQLYV--IVAQLFGGSHI---YKRDSFAN 316

  Fly   812 CHCCEFDACDCEMTCPTNCTCFH-DQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELA 875
            ......|....::..|.:...|. :..|...:.:.|.|.::                  ...:..
Human   317 KFIKIQDIEILKIRKPNDIETFKIENNWYFVVADSSKAGFT------------------TIYKWN 363

  Fly   876 GHSFLGRKNLAVLYANNS-NVAHIYNTTFSGLKRLLILHLEDNHIISLEGNE----FHN---LEN 932
            |:.|...::|...|.:.. ....|..|..:.....|||.......:..:.|:    |.|   :.|
Human   364 GNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLILSSSSQRPVIYQWNKATQLFTNQTDIPN 428

  Fly   933 LRELY------------------LQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANP 979
            :.::|                  :..:|:......|||     ::.|:.....|.|:..|::...
Human   429 MEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQ-----DIQRMPSRGSMVFQPLQINNYQ 488

  Fly   980 YLV---EISLAD-NQWSCECGYLARF------------------RNYLGQSSEK---------II 1013
            |.:   :.|... ..|..|.....:|                  ||:|..||.|         |:
Human   489 YAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIV 553

  Fly  1014 DAS 1016
            |.|
Human   554 DLS 556

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.