DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and IL18RAP

DIOPT Version :10

Sequence 1:NP_524081.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_003844.1 Gene:IL18RAP / 8807 HGNCID:5989 Length:599 Species:Homo sapiens


Alignment Length:624 Identity:131/624 - (20%)
Similarity:224/624 - (35%) Gaps:200/624 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   728 RILP--VWEHRALPEFYIGGNPFTCDCNIDWLQKINH-----ITSRQYPRIMDLETIYCKL---- 781
            |:.|  |.||  ||  ::|.|..:   ::.|.|:.::     ...:.||.|:..:   |.|    
Human    61 RLSPKQVPEH--LP--FMGSNDLS---DVQWYQQPSNGDPLEDIRKSYPHIIQDK---CTLHFLT 115

  Fly   782 --LNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTC----FHDQ---T 837
              :|| ..:||    ..||.....|...|     |.:.   ..|:...||.:|    .|.|   .
Human   116 PGVNN-SGSYI----CRPKMIKSPYDVAC-----CVKM---ILEVKPQTNASCEYSASHKQDLLL 167

  Fly   838 WSTNIVEC---SGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIY 899
            .||..:.|   |..:.::.|                               ||.:..|..:..:.
Human   168 GSTGSISCPSLSCQSDAQSP-------------------------------AVTWYKNGKLLSVE 201

  Fly   900 NTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLR--------- 955
            .:               |.|:..|..::|....:.: |.||:.::|....:...:|         
Human   202 RS---------------NRIVVDEVYDYHQGTYVCD-YTQSDTVSSWTVRAVVQVRTIVGDTKLK 250

  Fly   956 ---------KLEV-----LRLDGNRLMHFE-VWQLSANPYLV-EISLADNQWSCECGYLARFRNY 1004
                     .|||     |.:.......|| |:    ||.:. .|..:|.:|..........::.
Human   251 PDILDPVEDTLEVELGKPLTISCKARFGFERVF----NPVIKWYIKDSDLEWEVSVPEAKSIKST 311

  Fly  1005 LGQSSEKIIDASRV------------------SCIYNNATSV-LREKNGTKCTLRDGVAHYMHTN 1050
            |   .::||:.:.:                  :.|.|...|| |:||.|.       |..|:...
Human   312 L---KDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGV-------VLLYILLG 366

  Fly  1051 EIEGLLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQ-LDKERPND 1114
            .| |.|..:|.|:.            ..|||.::|      .|:...|:|.   || |..::..|
Human   367 TI-GTLVAVLAASA------------LLYRHWIEI------VLLYRTYQSK---DQTLGDKKDFD 409

  Fly  1115 AYFAY------------SLQDEHFVNQILAQTLENDIGYRLCLHYRDVNINAYITDALIEAAESA 1167
            |:.:|            ||.:||....:....|||..||.|||..|||.......:.::...:.:
Human   410 AFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRS 474

  Fly  1168 KQFVLVLSKNFLYNEWSRFEYKSALH-ELVKRRKRVVFI--LYGDLPQRDIDMDMRHYLRTSTCI 1229
            ::.:.:||.|:: |..|.||.::|:: .|..:..:::.|  .|...|: .:...::..||....:
Human   475 RRGIFILSPNYV-NGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPE-SLPHLVKKALRVLPTV 537

  Fly  1230 EW-------DDKKFWQKLRLALPLPNGRGN--NNKRVVS 1259
            .|       .:.:||.|:|..:|:.|.:|.  |..|:.|
Human   538 TWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITS 576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_524081.1 PPP1R42 <135..>242 CDD:455733
leucine-rich repeat 148..171 CDD:275380
leucine-rich repeat 172..201 CDD:275380
LRR_8 200..>246 CDD:404697
leucine-rich repeat 202..278 CDD:275380
leucine-rich repeat 229..249 CDD:275380
leucine-rich repeat 279..302 CDD:275380
LRR 299..654 CDD:443914
leucine-rich repeat 303..326 CDD:275380
leucine-rich repeat 327..350 CDD:275380
leucine-rich repeat 352..375 CDD:275380
leucine-rich repeat 376..401 CDD:275380
leucine-rich repeat 402..425 CDD:275380
leucine-rich repeat 426..449 CDD:275380
leucine-rich repeat 450..473 CDD:275380
leucine-rich repeat 474..497 CDD:275380
leucine-rich repeat 498..518 CDD:275380
leucine-rich repeat 521..544 CDD:275380
leucine-rich repeat 545..566 CDD:275380
leucine-rich repeat 569..592 CDD:275380
leucine-rich repeat 593..615 CDD:275380
leucine-rich repeat 616..637 CDD:275380
leucine-rich repeat 638..662 CDD:275380
LRR_8 662..719 CDD:404697
leucine-rich repeat 663..684 CDD:275380
leucine-rich repeat 685..708 CDD:275380
leucine-rich repeat 709..728 CDD:275380 131/624 (21%)
LRR <863..>990 CDD:443914 23/151 (15%)
leucine-rich repeat 885..908 CDD:275380 3/22 (14%)
leucine-rich repeat 909..932 CDD:275380 4/22 (18%)
leucine-rich repeat 933..956 CDD:275380 5/40 (13%)
TIR 1114..1247 CDD:214587 38/154 (25%)
IL18RAPNP_003844.1 Ig_6 36..165 CDD:465773 31/126 (25%)
Ig 162..>221 CDD:472250 13/104 (13%)
Ig strand B 171..175 CDD:409353 0/3 (0%)
Ig strand C 188..192 CDD:409353 2/3 (67%)
Ig strand E 204..208 CDD:409353 2/3 (67%)
Ig 251..354 CDD:472250 20/109 (18%)
Ig strand B 269..273 CDD:409353 1/3 (33%)
Ig strand C 286..290 CDD:409353 0/3 (0%)
Ig strand E 319..323 CDD:409353 0/3 (0%)
Ig strand F 334..339 CDD:409353 0/4 (0%)
Ig strand G 346..349 CDD:409353 0/2 (0%)
TIR 419..559 CDD:396246 34/141 (24%)
Blue background indicates that the domain is not in the aligned region.

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