DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and RLP12

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_177296.2	Gene:	RLP12 / 843481	AraportID:	AT1G71400	Length:	847	Species:	Arabidopsis thaliana

Alignment Length:	808	Identity:	200/808 - (24%)
Similarity:	320/808 - (39%)	Gaps:	195/808 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 LDQPEIALTCNLRTVNSEF--------DTTNFSVIPAEHTIALHILCN--DEIMAKSRLEAQSFA 143
            ||.|...|...|:|.:|.|        |.||               ||  .||       ..|..
plant    89 LDIPNTFLNNYLKTNSSLFKLQYLRHLDLTN---------------CNLYGEI-------PSSLG 131

  Fly   144 HLVRLQQLSIQYCK-LGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDL 207
            :|..|..:::.:.| :|.:...: ..|.|||:|.| .:|:    |..||.:...::: ||..|:|
plant   132 NLSHLTLVNLYFNKFVGEIPASI-GNLNQLRHLIL-ANNV----LTGEIPSSLGNLS-RLVNLEL 189

  Fly   208 SSNN-IWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSS 271
            .||. :..:||:| ..|.:|..|:::.|.|  :.|:                        .||..
plant   190 FSNRLVGKIPDSI-GDLKQLRNLSLASNNL--IGEI------------------------PSSLG 227

  Fly   272 STSCSLDLEYLDVSHNDFV-VLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSN 335
            :.|   :|.:|.::||..| .:||: .|.|..|||:|..||.:|.....:.:.|..|.|..||||
plant   228 NLS---NLVHLVLTHNQLVGEVPAS-IGNLIELRVMSFENNSLSGNIPISFANLTKLSIFVLSSN 288

  Fly   336 KIVA-LPTEL-------------------FAEQAKII---QEVYLQNNSISVLNPQLFSNLD--- 374
            ...: .|.::                   |.:...:|   :.:|||.|..:  .|..|:|..
plant   289 NFTSTFPFDMSIFHNLEYFDVSYNSFSGPFPKSLLLIPSLESIYLQENQFT--GPIEFANTSSST 351

  Fly   375 QLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENI 439
            :||.|.|..|::...  ...:...|:.|..|::|||..|...|...|.|..|..|:|..|.||
plant   352 KLQDLILGRNRLHGP--IPESISRLLNLEELDISHNNFTGAIPPTISKLVNLLHLDLSKNNLE-- 412

  Fly   440 AADTFAPMNNLHTLLLSHNK-------------LKYLD----------AYALNGLYVLSLLSLDN 481
             .:..|.:..|:|::||||.             ::.||          .|.:..|..|..|.|.|
plant   413 -GEVPACLWRLNTMVLSHNSFSSFENTSQEEALIEELDLNSNSFQGPIPYMICKLSSLGFLDLSN 476

  Fly   482 NALIGVHPDAFRNCS-ALQDLNLNGNQLK-TVPLALRNMRHLRTVDLGENMITVMEDSAFKGLGN 544
            |...|..|...||.| ::::|||..|... |:|........|.::|:..|.   :|....|.|.|
plant   477 NLFSGSIPSCIRNFSGSIKELNLGDNNFSGTLPDIFSKATELVSLDVSHNQ---LEGKFPKSLIN 538

  Fly   545 LYGLRLI---GNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSI--QAVRLDGNELN 604
            ...|.|:   .|.:::|.......||:|.:|||..|:.  ..| .:...:||  |::|:.....|
plant   539 CKALELVNVESNKIKDIFPSWLESLPSLHVLNLRSNKF--YGP-LYHRHASIGFQSLRIIDISHN 600

  Fly   605 DING-----LFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELK-- 662
            :.:|     .|||...:..|.      |..|. ::....::.|.:.:.:..::.  |:|...:
plant   601 NFSGTLPPYYFSNWKDMTTLT------EEMDQ-YMTEFWRYADSYYHEMEMVNK--GVDMSFERI 656

  Fly   663 ---LQTLDVSFNQLQRIGPSSIPNS------IELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQ 718
               .:.:|.|.|::.    .:||.|      :.:|.|:.|..|:|.|....:.|.|..:|:..|:
plant   657 RRDFRAIDFSGNKIN----GNIPESLGYLKELRVLNLSGNAFTSVIPRFLANLTKLETLDISRNK 717

  Fly   719 IT---TLDIKSLRILPV--WEHRALPEFYIGGNPF---TCDCNIDWLQKINHITSRQYPRIMDLE 775
            ::   ..|:.:|..|..  :.|..|......|..|   .|...:|            .|.:..||
plant   718 LSGQIPQDLAALSFLSYMNFSHNLLQGPVPRGTQFQRQKCSSFLD------------NPGLYGLE 770

  Fly   776 TIYCK---LLNNRERAYIPLIEAEPKHF 800
            .| |:   .||...:....|.|||...|
plant   771 DI-CRDTGALNPTSQLPEDLSEAEENMF 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380	4/23 (17%)
		LRR_8	171..236	CDD:290566	22/65 (34%)
		leucine-rich repeat	172..201	CDD:275380	8/28 (29%)
		leucine-rich repeat	202..278	CDD:275380	17/76 (22%)
		leucine-rich repeat	229..249	CDD:275380	4/19 (21%)
		LRR_RI	278..468	CDD:238064	64/239 (27%)
		leucine-rich repeat	279..302	CDD:275380	9/23 (39%)
		LRR_8	301..386	CDD:290566	29/110 (26%)
		leucine-rich repeat	303..326	CDD:275380	8/22 (36%)
		leucine-rich repeat	327..350	CDD:275380	8/42 (19%)
		LRR	350..729	CDD:227223	108/433 (25%)
		leucine-rich repeat	352..375	CDD:275380	8/28 (29%)
		leucine-rich repeat	376..401	CDD:275380	6/24 (25%)
		LRR_RI	<401..626	CDD:238064	71/259 (27%)
		leucine-rich repeat	402..425	CDD:275380	9/22 (41%)
		leucine-rich repeat	426..449	CDD:275380	7/22 (32%)
		leucine-rich repeat	450..473	CDD:275380	10/45 (22%)
		leucine-rich repeat	474..497	CDD:275380	10/23 (43%)
		leucine-rich repeat	498..518	CDD:275380	6/20 (30%)
		leucine-rich repeat	521..544	CDD:275380	6/22 (27%)
		leucine-rich repeat	545..566	CDD:275380	4/23 (17%)
		leucine-rich repeat	569..592	CDD:275380	6/22 (27%)
		leucine-rich repeat	593..615	CDD:275380	8/28 (29%)
		leucine-rich repeat	616..637	CDD:275380	3/20 (15%)
		leucine-rich repeat	638..662	CDD:275380	3/23 (13%)
		leucine-rich repeat	663..684	CDD:275380	5/20 (25%)
		leucine-rich repeat	685..708	CDD:275380	6/22 (27%)
		leucine-rich repeat	709..728	CDD:275380	4/21 (19%)
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
RLP12	NP_177296.2	LRRNT_2	36..80	CDD:285463
		LRR_8	112..170	CDD:290566	19/85 (22%)
		leucine-rich repeat	112..135	CDD:275380	9/44 (20%)
		leucine-rich repeat	136..159	CDD:275380	4/23 (17%)
		LRR_8	159..218	CDD:290566	22/65 (34%)
		leucine-rich repeat	160..183	CDD:275380	8/28 (29%)
		leucine-rich repeat	184..207	CDD:275380	9/23 (39%)
		LRR_RI	198..479	CDD:238064	82/318 (26%)
		LRR_8	206..266	CDD:290566	23/89 (26%)
		leucine-rich repeat	208..231	CDD:275380	8/51 (16%)
		leucine-rich repeat	232..255	CDD:275380	9/23 (39%)
		leucine-rich repeat	256..279	CDD:275380	8/22 (36%)
		leucine-rich repeat	280..352	CDD:275380	16/73 (22%)
		leucine-rich repeat	304..322	CDD:275380	1/17 (6%)
		LRR_8	351..411	CDD:290566	19/61 (31%)
		leucine-rich repeat	353..376	CDD:275380	6/24 (25%)
		LRR_RI	374..601	CDD:238064	66/235 (28%)
		leucine-rich repeat	377..400	CDD:275380	9/22 (41%)
		leucine-rich repeat	401..422	CDD:275380	7/23 (30%)
		leucine-rich repeat	445..468	CDD:275380	4/22 (18%)
		leucine-rich repeat	469..493	CDD:275380	10/23 (43%)
		leucine-rich repeat	494..517	CDD:275380	6/22 (27%)
		LRR_8	516..576	CDD:290566	18/62 (29%)
		leucine-rich repeat	518..541	CDD:275380	7/25 (28%)
		leucine-rich repeat	542..565	CDD:275380	5/22 (23%)
		leucine-rich repeat	592..616	CDD:275380	6/23 (26%)
		leucine-rich repeat	617..683	CDD:275380	12/78 (15%)
		LRR_8	682..742	CDD:290566	14/59 (24%)
		LRR_4	682..719	CDD:289563	10/36 (28%)
		leucine-rich repeat	684..707	CDD:275380	6/22 (27%)
		leucine-rich repeat	708..729	CDD:275380	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910