DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and BRL1

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001117501.1	Gene:	BRL1 / 842010	AraportID:	AT1G55610	Length:	1166	Species:	Arabidopsis thaliana

Alignment Length:	1231	Identity:	265/1231 - (21%)
Similarity:	436/1231 - (35%)	Gaps:	352/1231 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 GRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNI--WSLPDNIFC 221
            |.|....|..|..|:||.|:.:       .|....|:......|:.||||||:|  :|:.|.:|.
plant    91 GTLNLVNLTALPNLQNLYLQGN-------YFSSGGDSSGSDCYLQVLDLSSNSISDYSMVDYVFS 148

  Fly   222 TLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTE------SAKKSSSSSTSCSLDLE 280
            ..|.|.::|:|.|:|  |.:|||       ...|.:|.:|.:      |.|...|..:.....|:
plant   149 KCSNLVSVNISNNKL--VGKLGF-------APSSLQSLTTVDLSYNILSDKIPESFISDFPASLK 204

  Fly   281 YLDVSHN----DFVVLPANGFGTLRRLRVLSVNNNGISMIADK---ALSGLKNLQILNLSSNKIV 338
            |||::||    ||..|   .||....|...|::.|.:|  .||   .|...|.|:.||:|.|.:.
plant   205 YLDLTHNNLSGDFSDL---SFGICGNLTFFSLSQNNLS--GDKFPITLPNCKFLETLNISRNNLA 264

  Fly   339 ALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLV 403
            .                       .:.|.:.:.:...|:.|.|:.|:::.. |.....:....||
plant   265 G-----------------------KIPNGEYWGSFQNLKQLSLAHNRLSGE-IPPELSLLCKTLV 305

  Fly   404 LLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADT-FAPMNNLHTLLLSHNKLKYLDAYA 467
            :|:||.|..:...|..|:....||.|||.:|.|.....:| .:.:..:..|.:::|.:......:
plant   306 ILDLSGNTFSGELPSQFTACVWLQNLNLGNNYLSGDFLNTVVSKITGITYLYVAYNNISGSVPIS 370

  Fly   468 LNGLYVLSLLSLDNNALIGVHPDAFRNCS-----ALQDLNLNGNQLK-TVPLALRNMRHLRTVDL 526
            |.....|.:|.|.:|...|..|..|  ||     .|:.:.:..|.|. |||:.|...:.|:|:||
plant   371 LTNCSNLRVLDLSSNGFTGNVPSGF--CSLQSSPVLEKILIANNYLSGTVPMELGKCKSLKTIDL 433

  Fly   527 GENMI--------------------------TVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRD 565
            ..|.:                          |:.|....|| |||..|.|..|.|......:...
plant   434 SFNELTGPIPKEIWMLPNLSDLVMWANNLTGTIPEGVCVKG-GNLETLILNNNLLTGSIPESISR 497

  Fly   566 LPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELN-DINGLFSNMPSLLWLNISDNRLESF 629
            ..|:..::|:.||:....|......|.:..::|..|.|: ::.....|..||:||:::.|.|.
plant   498 CTNMIWISLSSNRLTGKIPSGIGNLSKLAILQLGNNSLSGNVPRQLGNCKSLIWLDLNSNNLT-- 560

  Fly   630 DYGHVPSTLQWL-------DLHKNRLSSLSNRFGLD----------------------------- 658
              |.:|..|...       .:...:.:.:.|..|.|
plant   561 --GDLPGELASQAGLVMPGSVSGKQFAFVRNEGGTDCRGAGGLVEFEGIRAERLERLPMVHSCPA 623

  Fly   659 ----SELKLQT---------LDVSFNQLQRIGPSSIPNS--IELLFLNDNLITTVDPDTFMHKTN 708
                |.:.:.|         .|:|:|.:....|....|.  :::|.|..|.||...||:|.
plant   624 TRIYSGMTMYTFSANGSMIYFDISYNAVSGFIPPGYGNMGYLQVLNLGHNRITGTIPDSFG---- 684

  Fly   709 LTRVDLYANQITTLDIKSLRILPVWEHRALPEFY---IGGNPFTCDCNIDWLQKINHITSRQYPR 770
                          .:|::.:|.: .|..|..:.   :|...|..|.::.     |:..:...|.
plant   685 --------------GLKAIGVLDL-SHNNLQGYLPGSLGSLSFLSDLDVS-----NNNLTGPIPF 729

  Fly   771 IMDLETI-YCKLLNNRERAYIPL--IEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTC 832
            ...|.|. ..:..||.....:||  ..:.|:..: |.:.|.
plant   730 GGQLTTFPVSRYANNSGLCGVPLRPCGSAPRRPI-TSRIHA------------------------ 769

  Fly   833 FHDQTWSTNIVECSGAAYSEM-----------PRRVPM--DTSELYIDGNNFVELAGHSFLGRKN 884
             ..||.:|.::  :|.|:|.|           .|:|..  ...|.||:     .|........|.
plant   770 -KKQTVATAVI--AGIAFSFMCFVMLVMALYRVRKVQKKEQKREKYIE-----SLPTSGSCSWKL 826

  Fly   885 LAVLYANNSNVAHIYNTTF-SGLKRLLILHLEDNHIISLEGNEFHNLENL------RELYLQSNK 942
            .:|....:.|||     || ..|::|...||       ||.....:.|.:      .|:|.
plant   827 SSVPEPLSINVA-----TFEKPLRKLTFAHL-------LEATNGFSAETMVGSGGFGEVYK---- 875

  Fly   943 IASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCECGYLARFRN---- 1003
             |.:.:||...::||  :|:.|.                     .|.::..|...:.:.::
plant   876 -AQLRDGSVVAIKKL--IRITGQ---------------------GDREFMAEMETIGKIKHRNLV 916

  Fly  1004 ----YLGQSSEKIIDASRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEGLLPLLLVATC 1064
                |.....|:::....:.  :.:..:||.||:..|    .|:  |::....:.:
plant   917 PLLGYCKVGEERLLVYEYMK--WGSLETVLHEKSSKK----GGI--YLNWAARKKI--------- 964

  Fly  1065 AFVAFFGLIF-GLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFA--YSLQDEHF 1126
            |..|..||.| ...|..|.:.....|:|.|:          |:..:.|.:|...|  .|..|.|
plant   965 AIGAARGLAFLHHSCIPHIIHRDMKSSNVLL----------DEDFEARVSDFGMARLVSALDTH- 1018

  Fly  1127 VNQILAQTLENDIGYRLCLHYRDVNINA---------YITDAL-----IEAAESAKQFVLVLSKN 1177
               :...||....||....:|:.....|         .:.:.|     |:..|..:...||
plant  1019 ---LSVSTLAGTPGYVPPEYYQSFRCTAKGDVYSYGVILLELLSGKKPIDPGEFGEDNNLV---- 1076

  Fly  1178 FLYNEWSRFEYKSALHELVKRRKRVVFILYGDL-PQRDIDMDMRHYLR-TSTCIEWDDKKF 1236
                .|::..|         |.||...||..:| ..:..|:::.|||: .|.|:  ||:.|
plant  1077 ----GWAKQLY---------REKRGAEILDPELVTDKSGDVELFHYLKIASQCL--DDRPF 1122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380	4/11 (36%)
		LRR_8	171..236	CDD:290566	22/66 (33%)
		leucine-rich repeat	172..201	CDD:275380	6/28 (21%)
		leucine-rich repeat	202..278	CDD:275380	27/83 (33%)
		leucine-rich repeat	229..249	CDD:275380	8/19 (42%)
		LRR_RI	278..468	CDD:238064	48/197 (24%)
		leucine-rich repeat	279..302	CDD:275380	11/26 (42%)
		LRR_8	301..386	CDD:290566	18/87 (21%)
		leucine-rich repeat	303..326	CDD:275380	7/25 (28%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		LRR	350..729	CDD:227223	95/463 (21%)
		leucine-rich repeat	352..375	CDD:275380	1/22 (5%)
		leucine-rich repeat	376..401	CDD:275380	5/24 (21%)
		LRR_RI	<401..626	CDD:238064	66/258 (26%)
		leucine-rich repeat	402..425	CDD:275380	8/22 (36%)
		leucine-rich repeat	426..449	CDD:275380	8/23 (35%)
		leucine-rich repeat	450..473	CDD:275380	3/22 (14%)
		leucine-rich repeat	474..497	CDD:275380	9/27 (33%)
		leucine-rich repeat	498..518	CDD:275380	7/20 (35%)
		leucine-rich repeat	521..544	CDD:275380	9/48 (19%)
		leucine-rich repeat	545..566	CDD:275380	5/20 (25%)
		leucine-rich repeat	569..592	CDD:275380	4/22 (18%)
		leucine-rich repeat	593..615	CDD:275380	4/22 (18%)
		leucine-rich repeat	616..637	CDD:275380	7/20 (35%)
		leucine-rich repeat	638..662	CDD:275380	5/63 (8%)
		leucine-rich repeat	663..684	CDD:275380	5/29 (17%)
		leucine-rich repeat	685..708	CDD:275380	8/22 (36%)
		leucine-rich repeat	709..728	CDD:275380	1/18 (6%)
		LRR_8	883..943	CDD:290566	16/66 (24%)
		leucine-rich repeat	885..908	CDD:275380	7/23 (30%)
		leucine-rich repeat	909..932	CDD:275380	5/22 (23%)
		LRR_8	932..990	CDD:290566	10/63 (16%)
		leucine-rich repeat	933..956	CDD:275380	5/28 (18%)
		TIR	1114..1247	CDD:214587	33/141 (23%)
BRL1	NP_001117501.1	PLN00113	33..1125	CDD:215061	265/1231 (22%)
		leucine-rich repeat	104..125	CDD:275380	6/27 (22%)
		LRR_RI	<125..318	CDD:238064	63/230 (27%)
		leucine-rich repeat	127..152	CDD:275380	11/24 (46%)
		leucine-rich repeat	153..176	CDD:275380	10/31 (32%)
		leucine-rich repeat	177..202	CDD:275380	4/24 (17%)
		leucine-rich repeat	203..227	CDD:275380	11/26 (42%)
		leucine-rich repeat	228..278	CDD:275380	14/74 (19%)
		leucine-rich repeat	279..303	CDD:275380	5/24 (21%)
		LRR_RI	298..569	CDD:238064	70/277 (25%)
		leucine-rich repeat	304..330	CDD:275380	9/25 (36%)
		leucine-rich repeat	331..376	CDD:275380	9/44 (20%)
		leucine-rich repeat	332..352	CDD:275380	5/19 (26%)
		leucine-rich repeat	377..400	CDD:275380	9/24 (38%)
		leucine-rich repeat	404..427	CDD:275380	7/22 (32%)
		leucine-rich repeat	428..451	CDD:275380	5/22 (23%)
		leucine-rich repeat	452..476	CDD:275380	4/24 (17%)
		leucine-rich repeat	477..500	CDD:275380	5/22 (23%)
		leucine-rich repeat	501..524	CDD:275380	4/22 (18%)
		leucine-rich repeat	525..546	CDD:275380	3/20 (15%)
		leucine-rich repeat	549..664	CDD:275380	18/118 (15%)
		leucine-rich repeat	612..660	CDD:275380	6/47 (13%)
		leucine-rich repeat	665..688	CDD:275380	8/40 (20%)
		leucine-rich repeat	689..710	CDD:275380	4/21 (19%)
		PKc_like	865..1136	CDD:304357	65/336 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	135	1.000	Inparanoid score	I1829
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050