DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and AT1G15740

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_563980.2	Gene:	AT1G15740 / 838143	AraportID:	AT1G15740	Length:	585	Species:	Arabidopsis thaliana

Alignment Length:	716	Identity:	162/716 - (22%)
Similarity:	266/716 - (37%)	Gaps:	203/716 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 STKHHQQQQLSHSNAIMGEAGVSNSQLMQPSTPARTLRPLTAGAGGDPSLYDAPDDCHFMPAAGL 89
            |.|..||.:...:..:.|:...|:|.....::.:|:...:....|..|||.:
plant    13 SRKRDQQVEDILNRGVSGKYSKSSSSKWLATSLSRSGSDVKRKNGECPSLME------------- 64

  Fly    90 DQPEIALTCNLRTVNSEFDT-TNFSVIPAEHTIALHILCNDEIMAKSRLEAQSFAHLVRLQQLSI 153
                   .| :|.:..:.|. |.||.:|.:  |:..|.  ||::...||..:|   |...:..:|
plant    65 -------LC-VRKIQEDIDRYTKFSDLPRD--ISQQIF--DELVYSQRLTLKS---LEAFRDCAI 114

  Fly   154 QYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIWSLPDN 218
            |...||.                       :|.:|.:......|.:..|..:|.|.::|   .|:
plant   115 QDLYLGE-----------------------YPGVNDDWMDVISSQSTSLLSVDFSGSDI---TDS 153

  Fly   219 IFCTL---SELSALNMS-----ENR-------LQDVNELGFRDRSKEPTNGSTESTSTTESAKKS 268
            ...:|   :.|.:||.:     .||       |.::..|.|| |:...|.....:.|...:.||
plant   154 GLVSLKGCTNLESLNFNFCDQISNRGLVHLSGLSNLTSLSFR-RNAAITAQGMRALSNLVNLKK- 216

  Fly   269 SSSSTSCSLDLEY---LDVSHNDFVVLPANGFGTLRRLRVL----SVNNNGISMIAD---KALSG 323
                    ||||.   :|              |.|..||.|    |:|....:.|.|   :.||.
plant   217 --------LDLEKCPGID--------------GGLVHLRALTKLESLNIKWCNCITDADMEPLSV 259

  Fly   324 LKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDL-SMNQIT 387
            |.||:.|.:..:||..:                    .||.|     ..|::|..|:| ....:|
plant   260 LTNLRSLQICCSKITDI--------------------GISYL-----KGLNKLNLLNLEGCRHVT 299

  Fly   388 STWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHT 452
            :..:|  |...|..|:.|||:....:....|.||||..|:||||..|.:.|........:..|.:
plant   300 AACLD--TLTALAGLMYLNLNRCNFSDSGCEKFSDLINLKILNLGMNNITNSCLVHLKGLTKLES 362

  Fly   453 LLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDL---------------- 501
            |.|...::.......|:|:..|..|.|.:..   |..:..|:.|.|.:|
plant   363 LNLDSCRIGDEGLVHLSGMLELKSLELSDTE---VGSNGLRHLSGLSNLESINLSFTVVTDSGLR 424

  Fly   502 NLNG-NQLKTVPL-----------ALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNY 554
            .|:| ..|:|:.|           ||.::..|..:||....||....:..:.|..|..|.:.|..
plant   425 KLSGLTSLRTLNLDARHVTDAGLSALTSLTGLTHLDLFGARITDSGTNHLRNLKKLQSLEICGGG 489

  Fly   555 LENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLLWL 619
            |.:..:...:||.:|.:|||::|             |::....|:         |.|.:..|:.|
plant   490 LTDTGVKNIKDLSSLTLLNLSQN-------------SNLTDKTLE---------LISGLTGLVSL 532

  Fly   620 NISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNS 684
            |:|::|:.|       |.|:.|...||..|           |.|::..:|.|.::::..:.:||.
plant   533 NVSNSRVSS-------SGLRHLKPLKNLRS-----------LTLESCKLSANDIRKLQATDLPNL 579

  Fly   685 I 685
            :
plant   580 V 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380	4/22 (18%)
		LRR_8	171..236	CDD:290566	14/79 (18%)
		leucine-rich repeat	172..201	CDD:275380	3/28 (11%)
		leucine-rich repeat	202..278	CDD:275380	20/90 (22%)
		leucine-rich repeat	229..249	CDD:275380	9/31 (29%)
		LRR_RI	278..468	CDD:238064	51/200 (26%)
		leucine-rich repeat	279..302	CDD:275380	5/25 (20%)
		LRR_8	301..386	CDD:290566	22/92 (24%)
		leucine-rich repeat	303..326	CDD:275380	10/29 (34%)
		leucine-rich repeat	327..350	CDD:275380	4/22 (18%)
		LRR	350..729	CDD:227223	86/365 (24%)
		leucine-rich repeat	352..375	CDD:275380	4/22 (18%)
		leucine-rich repeat	376..401	CDD:275380	7/25 (28%)
		LRR_RI	<401..626	CDD:238064	61/252 (24%)
		leucine-rich repeat	402..425	CDD:275380	9/22 (41%)
		leucine-rich repeat	426..449	CDD:275380	7/22 (32%)
		leucine-rich repeat	450..473	CDD:275380	5/22 (23%)
		leucine-rich repeat	474..497	CDD:275380	5/22 (23%)
		leucine-rich repeat	498..518	CDD:275380	9/47 (19%)
		leucine-rich repeat	521..544	CDD:275380	6/22 (27%)
		leucine-rich repeat	545..566	CDD:275380	4/20 (20%)
		leucine-rich repeat	569..592	CDD:275380	5/22 (23%)
		leucine-rich repeat	593..615	CDD:275380	3/21 (14%)
		leucine-rich repeat	616..637	CDD:275380	6/20 (30%)
		leucine-rich repeat	638..662	CDD:275380	5/23 (22%)
		leucine-rich repeat	663..684	CDD:275380	4/20 (20%)
		leucine-rich repeat	685..708	CDD:275380	0/1 (0%)
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
AT1G15740	NP_563980.2	leucine-rich repeat	62..98	CDD:275381	12/60 (20%)
		AMN1	86..275	CDD:187754	57/245 (23%)
		leucine-rich repeat	114..139	CDD:275381	7/47 (15%)
		leucine-rich repeat	164..188	CDD:275381	6/23 (26%)
		leucine-rich repeat	189..213	CDD:275381	6/24 (25%)
		leucine-rich repeat	214..237	CDD:275381	12/45 (27%)
		leucine-rich repeat	238..262	CDD:275381	7/23 (30%)
		leucine-rich repeat	263..297	CDD:275381	11/58 (19%)
		LRR_RI	<298..470	CDD:238064	45/176 (26%)
		leucine-rich repeat	298..335	CDD:275381	13/38 (34%)
		LRR_8	311..370	CDD:290566	19/58 (33%)
		leucine-rich repeat	336..359	CDD:275381	7/22 (32%)
		leucine-rich repeat	384..402	CDD:275380	5/20 (25%)
		leucine-rich repeat	408..431	CDD:275381	3/22 (14%)
		leucine-rich repeat	432..455	CDD:275381	5/22 (23%)
		leucine-rich repeat	456..479	CDD:275381	6/22 (27%)
		leucine-rich repeat	480..523	CDD:275381	13/64 (20%)
		leucine-rich repeat	529..552	CDD:275380	9/29 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000