DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and Slit3

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_112611.1 Gene:Slit3 / 83467 RGDID:69311 Length:1523 Species:Rattus norvegicus


Alignment Length:1712 Identity:345/1712 - (20%)
Similarity:557/1712 - (32%) Gaps:691/1712 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 QQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIW 213
            ::|.:....:.|:.:....||:.||.|.|..:.:      ..||..||...::||||.|:.|.:.
  Rat    64 ERLDLDRNNITRITKMDFTGLKNLRVLHLEDNQV------SVIERGAFQDLKQLERLRLNKNKLQ 122

  Fly   214 SLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLD 278
            .||:.:|.:..:|:.|::|||::|.:....||        |.|                     .
  Rat   123 VLPELLFQSTPKLTRLDLSENQIQGIPRKAFR--------GVT---------------------G 158

  Fly   279 LEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKI------ 337
            ::.|.:.:|....:....|..||.|.:|::|||.||.|...:.:.:..::.|.|.||.:      
  Rat   159 VKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHL 223

  Fly   338 ------------------------------------------------------VALP------- 341
                                                                  ::.|       
  Rat   224 AWLSDWLRQRRTIGQFTLCMAPVHLRGFSVADVQKKEYVCPGPHSEAPACNANSLSCPSACSCSN 288

  Fly   342 ----------TELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITS-------- 388
                      ||:.|...:.|.|:.|:.|||..:....|....:|:.:|:|.|||:.        
  Rat   289 NIVDCRGKGLTEIPANLPEGIVEIRLEQNSIKSIPAGAFIQYKKLKRIDISKNQISDIAPDAFQG 353

  Fly   389 --------------TWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENI 439
                          |.|.|..|.||:.|.||.|:.||:..|....|.||..|.:|:|..|:|:.|
  Rat   354 LKSLTSLVLYGNKITEIPKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTI 418

  Fly   440 AADTFAPMNNLHTLLLSHN------KLKYLDAY------ALNGLYVLSLLSLDNNALIGVHPDAF 492
            :...|||:.::.||.|:.|      .||:|..|      ..:|....|...|.|..:..:....|
  Rat   419 SKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKF 483

  Fly   493 RNCSALQD-------------------------LNLNGNQLKTVPLALRNMRHL--RTVD--LGE 528
            | ||..:|                         ::.:..:|..:|      .||  .|.|  |.:
  Rat   484 R-CSGSEDYRNRFSSECFMDLVCPEKCRCEGTIVDCSNQKLSRIP------SHLPEYTTDLRLND 541

  Fly   529 NMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSI 593
            |.|.|:|.:..                       |:.||||:.:||:.|||..|..|||:..:.:
  Rat   542 NDIAVLEATGI-----------------------FKKLPNLRKINLSNNRIKEVREGAFDGAAGV 583

  Fly   594 QAVRLDGNELNDING-LFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGL 657
            |.:.|.||:|..::| :|..:                      |.|:.|.|..|.:|.::|.   
  Rat   584 QELMLTGNQLETMHGRMFRGL----------------------SGLKTLMLRSNLISCVNND--- 623

  Fly   658 DSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTL 722
                       :|..|         :|:.||.|.||.|||:.|..|....:|:.::|.:      
  Rat   624 -----------TFAGL---------SSVRLLSLYDNRITTISPGAFTTLVSLSTINLLS------ 662

  Fly   723 DIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQY----PRIMDLETIYCKLLN 783
                                   |||.|:|::.||.:  .:..|:.    ||..  :..:.|   
  Rat   663 -----------------------NPFNCNCHMAWLGR--WLRKRRIVSGNPRCQ--KPFFLK--- 697

  Fly   784 NRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGA 848
                 .||:.:...:.|.|...          |.::|.....||..|||..      .:|.||..
  Rat   698 -----EIPIQDVAIQDFTCEGN----------EENSCQLSPRCPEQCTCVE------TVVRCSNR 741

  Fly   849 AYSEMPRRVPMDTSELYIDGNNFV----ELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRL 909
            ....:|:.:|.|.:|||::||:..    ||:  :|   :.|.::..:|::::.:.|.|||.:..|
  Rat   742 GLHTLPKGMPKDVTELYLEGNHLTAVPKELS--TF---RQLTLIDLSNNSISMLTNHTFSNMSHL 801

  Fly   910 LILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEV-- 972
            ..|.|..|.:..:..:.|:.|.:||.|.|..|.|:|:..|||..|..|..|.|..|.| |.:.  
  Rat   802 STLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGINPL-HCDCSL 865

  Fly   973 -WQLS-------ANPYLVEI----SLAD------------------------------------- 988
             | ||       ..|.:...    |:||                                     
  Rat   866 RW-LSEWIKAGYKEPGIARCSSPESMADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNG 929

  Fly   989 -------NQWSCECGYLARFRNYLGQSSEKIIDASRVSCIYN----NATSVLREKN--------- 1033
                   .|:.|.|.|     :|.|:.....|:    :|:.|    ..|..|.|.:         
  Rat   930 TCSQDPVEQYRCTCPY-----SYKGKDCTVPIN----TCVQNPCQHGGTCHLSESHRDGFSCSCP 985

  Fly  1034 ----GTKC----------------TLRDGVAHYM------HTNEIEGLLPLLLVATCAFVAFFGL 1072
                |.:|                |..||:.:|.      :|.|:           |..|..   
  Rat   986 LGFEGQRCEINPDDCEDNDCENSATCVDGINNYACVCPPNYTGEL-----------CDEVID--- 1036

  Fly  1073 IFGLFCYRHELKIWAHSTNCL---MNF-CYKSPRFVDQLDKERPNDAYFAYSLQD---------- 1123
                :|. .|:.:..|...|:   ..| |...|.:..:| .|..||...|:..:.          
  Rat  1037 ----YCV-PEMNLCQHEAKCISLDKGFRCECVPGYSGKL-CETDNDDCVAHKCRHGAQCVDAVNG 1095

  Fly  1124 --------------EHFVNQILAQTLENDIGYRLCLHYRDVNINAYITDALIEAAESAKQFVL-- 1172
                          ||....:|.||..       |..|              |....|:..|:  
  Rat  1096 YTCICPQGFSGLFCEHPPPMVLLQTSP-------CDQY--------------ECQNGAQCIVVQQ 1139

  Fly  1173 -----------------VLSKNFLYNEWSRFEYKSALHELVKRRKRVVFILYGDLPQRDIDMDMR 1220
                             :::.||:        .|.:..||...:.|         ||.:|     
  Rat  1140 EPTCRCPPGFAGPRCEKLITVNFV--------GKDSYVELASAKVR---------PQANI----- 1182

  Fly  1221 HYLRTSTCIEWDDKKFWQKLRLALPLPNG----RGNNNK----------RVVSGCLSGRTPSVNM 1271
                              .|::|....||    :|:|:.          |:|...||  :|...:
  Rat  1183 ------------------SLQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLS--SPPTTV 1227

  Fly  1272 YATSHEYQAGNGG--------VIPPPSARYADCGS-NNYATINECAAAG-------GGRGYKPIP 1320
            |:.    :..|.|        ::........|.|: .:...:.:..|.|       ||     ||
  Rat  1228 YSV----ETVNDGQFHSVELVMLNQTLNLVVDKGAPKSLGKLQKQPAVGINSPLYLGG-----IP 1283

  Fly  1321 TSASAAAAACKFNTMNQLSKKQQRDLSVAGMAKTLEHQHHHNHQANRRSQHEYAVPSYLPSAAPA 1385
            ||...:|.            :|..|..:.|.     |...|..:.|...|...|:|......:|.
  Rat  1284 TSTGLSAL------------RQGADRPLGGF-----HGCIHEVRINNELQDFKALPPQSLGVSPG 1331

  Fly  1386 YDSVDYAKQQI-----RNNANCEC---------------------VNLGT---------AKRAAG 1415
            ..|....:..:     :::..|||                     .:.||         .|.|.|
  Rat  1332 CKSCTVCRHGLCRSVEKDSVVCECHPGWTGPLCDQEAQDPCLGHSCSHGTCVATGNSYVCKCAEG 1396

  Fly  1416 --------KNPASGLPSSFSSN--------------FVPPGGASYNCKKSCSCIGD--------- 1449
                    ||.::...|:|..:              ...||.:..:|::...|:|:         
  Rat  1397 YEGPLCDQKNDSANACSAFKCHHGQCHISDRGEPYCLCQPGFSGNHCEQENPCLGEIVREAIRRQ 1461

  Fly  1450 -DELLCS---------CGGGGG 1461
             |...|:         |.||.|
  Rat  1462 KDYASCATASKVPIMVCRGGCG 1483

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380 4/21 (19%)
LRR_8 171..236 CDD:290566 22/64 (34%)
leucine-rich repeat 172..201 CDD:275380 8/28 (29%)
leucine-rich repeat 202..278 CDD:275380 19/75 (25%)
leucine-rich repeat 229..249 CDD:275380 7/19 (37%)
LRR_RI 278..468 CDD:238064 67/300 (22%)
leucine-rich repeat 279..302 CDD:275380 4/22 (18%)
LRR_8 301..386 CDD:290566 28/161 (17%)
leucine-rich repeat 303..326 CDD:275380 8/22 (36%)
leucine-rich repeat 327..350 CDD:275380 8/99 (8%)
LRR 350..729 CDD:227223 109/442 (25%)
leucine-rich repeat 352..375 CDD:275380 7/22 (32%)
leucine-rich repeat 376..401 CDD:275380 12/46 (26%)
LRR_RI <401..626 CDD:238064 68/266 (26%)
leucine-rich repeat 402..425 CDD:275380 10/22 (45%)
leucine-rich repeat 426..449 CDD:275380 9/22 (41%)
leucine-rich repeat 450..473 CDD:275380 9/34 (26%)
leucine-rich repeat 474..497 CDD:275380 6/22 (27%)
leucine-rich repeat 498..518 CDD:275380 3/44 (7%)
leucine-rich repeat 521..544 CDD:275380 8/26 (31%)
leucine-rich repeat 545..566 CDD:275380 1/20 (5%)
leucine-rich repeat 569..592 CDD:275380 10/22 (45%)
leucine-rich repeat 593..615 CDD:275380 7/22 (32%)
leucine-rich repeat 616..637 CDD:275380 0/20 (0%)
leucine-rich repeat 638..662 CDD:275380 6/23 (26%)
leucine-rich repeat 663..684 CDD:275380 2/20 (10%)
leucine-rich repeat 685..708 CDD:275380 10/22 (45%)
leucine-rich repeat 709..728 CDD:275380 2/18 (11%)
LRR_8 883..943 CDD:290566 17/59 (29%)
leucine-rich repeat 885..908 CDD:275380 6/22 (27%)
leucine-rich repeat 909..932 CDD:275380 6/22 (27%)
LRR_8 932..990 CDD:290566 24/115 (21%)
leucine-rich repeat 933..956 CDD:275380 11/22 (50%)
TIR 1114..1247 CDD:214587 23/175 (13%)
Slit3NP_112611.1 leucine-rich repeat 311..332 CDD:275380 6/20 (30%)
LRR_4 331..371 CDD:289563 7/39 (18%)
LRR 8 332..353 6/20 (30%)
leucine-rich repeat 333..356 CDD:275380 6/22 (27%)
LRR_8 355..439 CDD:290566 29/83 (35%)
LRR 9 356..377 4/20 (20%)
leucine-rich repeat 357..377 CDD:275380 4/19 (21%)
LRR 10 380..401 8/20 (40%)
leucine-rich repeat 381..404 CDD:275380 10/22 (45%)
LRR 11 404..425 7/20 (35%)
leucine-rich repeat 405..426 CDD:275380 8/20 (40%)
TPKR_C2 437..>467 CDD:301599 6/29 (21%)
LRRNT 505..535 CDD:214470 4/35 (11%)
LRR 12 533..554 7/43 (16%)
leucine-rich repeat 534..558 CDD:275380 9/46 (20%)
LRR_4 535..574 CDD:289563 17/61 (28%)
LRR_8 557..617 CDD:290566 24/81 (30%)
LRR 13 558..579 11/20 (55%)
leucine-rich repeat 559..582 CDD:275380 10/22 (45%)
LRR 14 582..603 7/20 (35%)
leucine-rich repeat 583..606 CDD:275380 7/44 (16%)
LRR_8 605..665 CDD:290566 23/111 (21%)
LRR 15 606..627 7/34 (21%)
leucine-rich repeat 607..630 CDD:275380 8/45 (18%)
LRR 16 630..651 11/20 (55%)
leucine-rich repeat 631..654 CDD:275380 10/22 (45%)
leucine-rich repeat 655..745 CDD:275380 27/146 (18%)
LRRCT 663..711 CDD:214507 14/59 (24%)
LRRNT 725..756 CDD:214470 11/36 (31%)
LRR_RI <741..869 CDD:238064 41/134 (31%)
leucine-rich repeat 746..776 CDD:275380 11/34 (32%)
LRR 17 753..774 8/22 (36%)
LRR_8 775..835 CDD:290566 17/59 (29%)
LRR 18 776..797 5/20 (25%)
leucine-rich repeat 777..800 CDD:275380 6/22 (27%)
LRR 19 800..821 5/20 (25%)
leucine-rich repeat 801..824 CDD:275380 6/22 (27%)
LRR 20 824..845 10/20 (50%)
leucine-rich repeat 825..846 CDD:275380 10/20 (50%)
LRRCT 857..906 CDD:214507 10/50 (20%)
EGF_CA 956..994 CDD:238011 7/41 (17%)
EGF_CA 998..1031 CDD:238011 6/43 (14%)
EGF_CA 1035..1072 CDD:238011 8/45 (18%)
EGF_CA 1074..1110 CDD:238011 3/35 (9%)
EGF 1123..1153 CDD:278437 5/43 (12%)
Laminin_G_2 1188..1314 CDD:280389 29/153 (19%)
EGF_CA 1370..1402 CDD:238011 5/31 (16%)
GHB_like 1463..1519 CDD:304424 6/21 (29%)
LRRNT 33..60 CDD:279764
LRR_RI <49..220 CDD:238064 48/190 (25%)
LRR_8 61..121 CDD:290566 18/62 (29%)
LRR 1 62..83 2/18 (11%)
leucine-rich repeat 64..86 CDD:275380 4/21 (19%)
LRR 2 86..107 8/26 (31%)
leucine-rich repeat 87..110 CDD:275380 8/28 (29%)
LRR_8 109..169 CDD:290566 21/88 (24%)
LRR 3 110..131 9/20 (45%)
leucine-rich repeat 111..134 CDD:275380 9/22 (41%)
LRR 4 134..155 8/28 (29%)
leucine-rich repeat 135..158 CDD:275380 10/51 (20%)
LRR_8 157..217 CDD:290566 18/80 (23%)
LRR 5 158..179 3/20 (15%)
leucine-rich repeat 159..182 CDD:275380 4/22 (18%)
LRR 6 182..203 8/20 (40%)
leucine-rich repeat 183..206 CDD:275380 8/22 (36%)
leucine-rich repeat 207..309 CDD:275380 8/101 (8%)
LRRNT 280..311 CDD:214470 5/30 (17%)
LRR_RI <295..457 CDD:238064 49/161 (30%)
LRR 7 308..329 7/20 (35%)
LRR_8 311..367 CDD:290566 12/55 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45836
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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