DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and EMS1

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_196345.1 Gene:EMS1 / 830619 AraportID:AT5G07280 Length:1192 Species:Arabidopsis thaliana


Alignment Length:1234 Identity:278/1234 - (22%)
Similarity:450/1234 - (36%) Gaps:347/1234 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   246 DRSKEPTN-----GSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRV 305
            |.|.|.|:     .|.|:.|...|...|||:             ||.|:|.:..    .|.|:..
plant    22 DLSSETTSLISFKRSLENPSLLSSWNVSSSA-------------SHCDWVGVTC----LLGRVNS 69

  Fly   306 LSVNNNGISMIADKALSGLKNLQILNLSSNKIVA-LPTELFAEQAKIIQEVYLQNNSISVLNPQL 369
            ||:.:..:.....|.:|.||||:.|.|:.|:... :|.|::  ..|.:|.:.|..||::.|.|:|
plant    70 LSLPSLSLRGQIPKEISSLKNLRELCLAGNQFSGKIPPEIW--NLKHLQTLDLSGNSLTGLLPRL 132

  Fly   370 FSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLT-KLEPEI-----FSDLY---- 424
            .|.|.||..||||.|..:.: :..:.|:.|..|..|::|:|.|: ::.|||     .|:||    
plant   133 LSELPQLLYLDLSDNHFSGS-LPPSFFISLPALSSLDVSNNSLSGEIPPEIGKLSNLSNLYMGLN 196

  Fly   425 ------TLQILNLRHNQLENIAADT----------FAPMNNLHTLLLSHNKLKYLDAYALNGLYV 473
                  ..:|.|:  :.|:|.||.:          .:.:.:|..|.||:|.||.....:...|:.
plant   197 SFSGQIPSEIGNI--SLLKNFAAPSCFFNGPLPKEISKLKHLAKLDLSYNPLKCSIPKSFGELHN 259

  Fly   474 LSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLK-TVPLALRNMRHLRTVDLGENMITVMEDS 537
            ||:|:|.:..|||:.|....||.:|:.|.|:.|.|. .:||.|..: .|.|.....|.::....|
plant   260 LSILNLVSAELIGLIPPELGNCKSLKSLMLSFNSLSGPLPLELSEI-PLLTFSAERNQLSGSLPS 323

  Fly   538 AFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNE 602
            .......|..|.|..|.......|...|.|.|:.|:||.|.::...|.....:.|::|:.|.||.
plant   324 WMGKWKVLDSLLLANNRFSGEIPHEIEDCPMLKHLSLASNLLSGSIPRELCGSGSLEAIDLSGNL 388

  Fly   603 LN-DINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQW------LDLHKNRLSSLSNRFGLDSE 660
            |: .|..:|....||..|.:::|::.    |.:|..| |      |||..|..:....: .|...
plant   389 LSGTIEEVFDGCSSLGELLLTNNQIN----GSIPEDL-WKLPLMALDLDSNNFTGEIPK-SLWKS 447

  Fly   661 LKLQTLDVSFNQLQRIGPSSIPN--SIELLFLNDNLITTVDPDTFMHKTNLTRVDLYAN------ 717
            ..|.....|:|:|:...|:.|.|  |::.|.|:||.:|...|......|:|:.::|.||      
plant   448 TNLMEFTASYNRLEGYLPAEIGNAASLKRLVLSDNQLTGEIPREIGKLTSLSVLNLNANMFQGKI 512

  Fly   718 --------QITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDL 774
                    .:||||:.|                                  |::..:...:|..|
plant   513 PVELGDCTSLTTLDLGS----------------------------------NNLQGQIPDKITAL 543

  Fly   775 ETIYCKLL--NN-------RERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPT-- 828
            ..:.|.:|  ||       :..||...||.....||          .|...||.....::.|.  
plant   544 AQLQCLVLSYNNLSGSIPSKPSAYFHQIEMPDLSFL----------QHHGIFDLSYNRLSGPIPE 598

  Fly   829 ---NCTCFHDQTWSTN-----------------IVECSGAAYS-EMPRRVPMDTSELYIDGNNFV 872
               .|....:.:.|.|                 |::.||.|.: .:|:.:   .:.|.:.|.|..
plant   599 ELGECLVLVEISLSNNHLSGEIPASLSRLTNLTILDLSGNALTGSIPKEM---GNSLKLQGLNLA 660

  Fly   873 --ELAGH---SF--LGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNL 930
              :|.||   ||  ||  :|..|....:.:......:...||.|..:.|..|::.....:|...:
plant   661 NNQLNGHIPESFGLLG--SLVKLNLTKNKLDGPVPASLGNLKELTHMDLSFNNLSGELSSELSTM 723

  Fly   931 ENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCEC 995
            |.|..||::.||...........|.:||.|.:..|.|......::...|.|..::||.|      
plant   724 EKLVGLYIEQNKFTGEIPSELGNLTQLEYLDVSENLLSGEIPTKICGLPNLEFLNLAKN------ 782

  Fly   996 GYLARFRNYLGQ---------SSEKIIDASRVSC--IYNNATSVLREKNGTKCTLRDGVAHYMHT 1049
                   |..|:         .|:.::..::..|  :..:...:    .|||.....|:|     
plant   783 -------NLRGEVPSDGVCQDPSKALLSGNKELCGRVVGSDCKI----EGTKLRSAWGIA----- 831

  Fly  1050 NEIEGLLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNC-------------LMNFCYKSP 1101
                ||:             .|....:|.:...|:.||.:...             |..|..::.
plant   832 ----GLM-------------LGFTIIVFVFVFSLRRWAMTKRVKQRDDPERMEESRLKGFVDQNL 879

  Fly  1102 RFVDQLDKERP---NDAYFAYSL----------QDEHFVNQILAQTLENDIG-------YRLCLH 1146
            .|:.......|   |.|.|...|          ..:||       :.:|.||       |:.||.
plant   880 YFLSGSRSREPLSINIAMFEQPLLKVRLGDIVEATDHF-------SKKNIIGDGGFGTVYKACLP 937

  Fly  1147 YRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHEL--VKRRKRVVFILYGD 1209
            ...       |.|:.:.:|:..|              ...|:.:.:..|  ||....|..:.|..
plant   938 GEK-------TVAVKKLSEAKTQ--------------GNREFMAEMETLGKVKHPNLVSLLGYCS 981

  Fly  1210 LPQRD-------IDMDMRHYLRTST----CIEWDDKKFWQKLRLALPLPNG-------------- 1249
            ..:..       ::..:.|:||..|    .::|.     ::|::|:....|              
plant   982 FSEEKLLVYEYMVNGSLDHWLRNQTGMLEVLDWS-----KRLKIAVGAARGLAFLHHGFIPHIIH 1041

  Fly  1250 ---RGNN---------------NKRVVSGCLSGRTPSVNMYATSHEYQAGNGGVIPP---PSAR 1292
               :.:|               ..|::|.|.|..:..:          ||..|.|||   .|||
plant  1042 RDIKASNILLDGDFEPKVADFGLARLISACESHVSTVI----------AGTFGYIPPEYGQSAR 1095

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380 11/36 (31%)
leucine-rich repeat 229..249 CDD:275380 1/2 (50%)
LRR_RI 278..468 CDD:238064 62/216 (29%)
leucine-rich repeat 279..302 CDD:275380 5/22 (23%)
LRR_8 301..386 CDD:290566 31/85 (36%)
leucine-rich repeat 303..326 CDD:275380 5/22 (23%)
leucine-rich repeat 327..350 CDD:275380 6/23 (26%)
LRR 350..729 CDD:227223 124/428 (29%)
leucine-rich repeat 352..375 CDD:275380 9/22 (41%)
leucine-rich repeat 376..401 CDD:275380 8/24 (33%)
LRR_RI <401..626 CDD:238064 72/252 (29%)
leucine-rich repeat 402..425 CDD:275380 11/38 (29%)
leucine-rich repeat 426..449 CDD:275380 6/32 (19%)
leucine-rich repeat 450..473 CDD:275380 8/22 (36%)
leucine-rich repeat 474..497 CDD:275380 10/22 (45%)
leucine-rich repeat 498..518 CDD:275380 8/20 (40%)
leucine-rich repeat 521..544 CDD:275380 4/22 (18%)
leucine-rich repeat 545..566 CDD:275380 5/20 (25%)
leucine-rich repeat 569..592 CDD:275380 6/22 (27%)
leucine-rich repeat 593..615 CDD:275380 7/22 (32%)
leucine-rich repeat 616..637 CDD:275380 5/20 (25%)
leucine-rich repeat 638..662 CDD:275380 7/29 (24%)
leucine-rich repeat 663..684 CDD:275380 7/22 (32%)
leucine-rich repeat 685..708 CDD:275380 6/22 (27%)
leucine-rich repeat 709..728 CDD:275380 9/32 (28%)
LRR_8 883..943 CDD:290566 13/59 (22%)
leucine-rich repeat 885..908 CDD:275380 3/22 (14%)
leucine-rich repeat 909..932 CDD:275380 4/22 (18%)
LRR_8 932..990 CDD:290566 15/57 (26%)
leucine-rich repeat 933..956 CDD:275380 6/22 (27%)
TIR 1114..1247 CDD:214587 28/162 (17%)
EMS1NP_196345.1 PLN00113 30..1190 CDD:215061 274/1226 (22%)
leucine-rich repeat 91..114 CDD:275380 6/24 (25%)
leucine-rich repeat 115..138 CDD:275380 9/22 (41%)
leucine-rich repeat 139..163 CDD:275380 8/24 (33%)
leucine-rich repeat 164..187 CDD:275380 8/22 (36%)
leucine-rich repeat 188..211 CDD:275380 5/24 (21%)
leucine-rich repeat 212..235 CDD:275380 4/22 (18%)
PLN03150 <224..307 CDD:178695 26/83 (31%)
leucine-rich repeat 236..259 CDD:275380 8/22 (36%)
leucine-rich repeat 260..283 CDD:275380 10/22 (45%)
leucine-rich repeat 284..303 CDD:275380 7/18 (39%)
leucine-rich repeat 333..350 CDD:275380 4/16 (25%)
leucine-rich repeat 355..378 CDD:275380 6/22 (27%)
leucine-rich repeat 379..402 CDD:275380 7/22 (32%)
leucine-rich repeat 403..424 CDD:275380 7/25 (28%)
leucine-rich repeat 426..449 CDD:275380 5/23 (22%)
leucine-rich repeat 450..473 CDD:275380 7/22 (32%)
leucine-rich repeat 474..497 CDD:275380 6/22 (27%)
leucine-rich repeat 498..521 CDD:275380 4/22 (18%)
leucine-rich repeat 522..545 CDD:275380 8/56 (14%)
leucine-rich repeat 546..578 CDD:275380 8/31 (26%)
leucine-rich repeat 579..604 CDD:275380 5/34 (15%)
leucine-rich repeat 606..629 CDD:275380 2/22 (9%)
leucine-rich repeat 630..646 CDD:275380 4/15 (27%)
leucine-rich repeat 654..677 CDD:275380 9/24 (38%)
leucine-rich repeat 678..701 CDD:275380 3/22 (14%)
leucine-rich repeat 702..725 CDD:275380 4/22 (18%)
leucine-rich repeat 726..749 CDD:275380 6/22 (27%)
leucine-rich repeat 750..773 CDD:275380 5/22 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 135 1.000 Inparanoid score I1829
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.050

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