DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and EMS1

DIOPT Version :10

Sequence 1:NP_524081.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_196345.1 Gene:EMS1 / 830619 AraportID:AT5G07280 Length:1192 Species:Arabidopsis thaliana


Alignment Length:1237 Identity:280/1237 - (22%)
Similarity:451/1237 - (36%) Gaps:353/1237 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   246 DRSKEPTN-----GSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRV 305
            |.|.|.|:     .|.|:.|...|...|||:             ||.|:|.:..    .|.|:..
plant    22 DLSSETTSLISFKRSLENPSLLSSWNVSSSA-------------SHCDWVGVTC----LLGRVNS 69

  Fly   306 LSVNNNGISMIADKALSGLKNLQILNLSSNKIVA-LPTELFAEQAKIIQEVYLQNNSISVLNPQL 369
            ||:.:..:.....|.:|.||||:.|.|:.|:... :|.|::  ..|.:|.:.|..||::.|.|:|
plant    70 LSLPSLSLRGQIPKEISSLKNLRELCLAGNQFSGKIPPEIW--NLKHLQTLDLSGNSLTGLLPRL 132

  Fly   370 FSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLT-KLEPEI-----FSDLY---- 424
            .|.|.||..||||.|..:.: :..:.|:.|..|..|::|:|.|: ::.|||     .|:||    
plant   133 LSELPQLLYLDLSDNHFSGS-LPPSFFISLPALSSLDVSNNSLSGEIPPEIGKLSNLSNLYMGLN 196

  Fly   425 ------TLQILNLRHNQLENIAADT----------FAPMNNLHTLLLSHNKLKYLDAYALNGLYV 473
                  ..:|.|:  :.|:|.||.:          .:.:.:|..|.||:|.||.....:...|:.
plant   197 SFSGQIPSEIGNI--SLLKNFAAPSCFFNGPLPKEISKLKHLAKLDLSYNPLKCSIPKSFGELHN 259

  Fly   474 LSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLK-TVPLALRNMRHLRTVDLGENMITVMEDS 537
            ||:|:|.:..|||:.|....||.:|:.|.|:.|.|. .:||.|..: .|.|.....|.::....|
plant   260 LSILNLVSAELIGLIPPELGNCKSLKSLMLSFNSLSGPLPLELSEI-PLLTFSAERNQLSGSLPS 323

  Fly   538 AFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNE 602
            .......|..|.|..|.......|...|.|.|:.|:||.|.::...|.....:.|::|:.|.||.
plant   324 WMGKWKVLDSLLLANNRFSGEIPHEIEDCPMLKHLSLASNLLSGSIPRELCGSGSLEAIDLSGNL 388

  Fly   603 LN-DINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSL---SNRF------GL 657
            |: .|..:|....||..|.:::|::.    |.:|.     ||.|..|.:|   ||.|      .|
plant   389 LSGTIEEVFDGCSSLGELLLTNNQIN----GSIPE-----DLWKLPLMALDLDSNNFTGEIPKSL 444

  Fly   658 DSELKLQTLDVSFNQLQRIGPSSIPN--SIELLFLNDNLITTVDPDTFMHKTNLTRVDLYAN--- 717
            .....|.....|:|:|:...|:.|.|  |::.|.|:||.:|...|......|:|:.::|.||   
plant   445 WKSTNLMEFTASYNRLEGYLPAEIGNAASLKRLVLSDNQLTGEIPREIGKLTSLSVLNLNANMFQ 509

  Fly   718 -----------QITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRI 771
                       .:||||:.|                                  |::..:...:|
plant   510 GKIPVELGDCTSLTTLDLGS----------------------------------NNLQGQIPDKI 540

  Fly   772 MDLETIYCKLL--NN-------RERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCP 827
            ..|..:.|.:|  ||       :..||...||.....||          .|...||.....::.|
plant   541 TALAQLQCLVLSYNNLSGSIPSKPSAYFHQIEMPDLSFL----------QHHGIFDLSYNRLSGP 595

  Fly   828 T-----NCTCFHDQTWSTN-----------------IVECSGAAYS-EMPRRVPMDTSELYIDGN 869
            .     .|....:.:.|.|                 |::.||.|.: .:|:.:   .:.|.:.|.
plant   596 IPEELGECLVLVEISLSNNHLSGEIPASLSRLTNLTILDLSGNALTGSIPKEM---GNSLKLQGL 657

  Fly   870 NFV--ELAGH---SF--LGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEF 927
            |..  :|.||   ||  ||  :|..|....:.:......:...||.|..:.|..|::.....:|.
plant   658 NLANNQLNGHIPESFGLLG--SLVKLNLTKNKLDGPVPASLGNLKELTHMDLSFNNLSGELSSEL 720

  Fly   928 HNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWS 992
            ..:|.|..||::.||...........|.:||.|.:..|.|......::...|.|..::||.|   
plant   721 STMEKLVGLYIEQNKFTGEIPSELGNLTQLEYLDVSENLLSGEIPTKICGLPNLEFLNLAKN--- 782

  Fly   993 CECGYLARFRNYLGQ---------SSEKIIDASRVSC--IYNNATSVLREKNGTKCTLRDGVAHY 1046
                      |..|:         .|:.::..::..|  :..:...:    .|||.....|:|  
plant   783 ----------NLRGEVPSDGVCQDPSKALLSGNKELCGRVVGSDCKI----EGTKLRSAWGIA-- 831

  Fly  1047 MHTNEIEGLLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNC-------------LMNFCY 1098
                   ||:             .|....:|.:...|:.||.:...             |..|..
plant   832 -------GLM-------------LGFTIIVFVFVFSLRRWAMTKRVKQRDDPERMEESRLKGFVD 876

  Fly  1099 KSPRFVDQLDKERP---NDAYFAYSL----------QDEHFVNQILAQTLENDIG-------YRL 1143
            ::..|:.......|   |.|.|...|          ..:||       :.:|.||       |:.
plant   877 QNLYFLSGSRSREPLSINIAMFEQPLLKVRLGDIVEATDHF-------SKKNIIGDGGFGTVYKA 934

  Fly  1144 CLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHEL--VKRRKRVVFIL 1206
            ||....       |.|:.:.:|:..|              ...|:.:.:..|  ||....|..:.
plant   935 CLPGEK-------TVAVKKLSEAKTQ--------------GNREFMAEMETLGKVKHPNLVSLLG 978

  Fly  1207 YGDLPQRD-------IDMDMRHYLRTST----CIEWDDKKFWQKLRLALPLPNG----------- 1249
            |....:..       ::..:.|:||..|    .::|.     ::|::|:....|           
plant   979 YCSFSEEKLLVYEYMVNGSLDHWLRNQTGMLEVLDWS-----KRLKIAVGAARGLAFLHHGFIPH 1038

  Fly  1250 ------RGNN---------------NKRVVSGCLSGRTPSVNMYATSHEYQAGNGGVIPP---PS 1290
                  :.:|               ..|::|.|.|..:..:          ||..|.|||   .|
plant  1039 IIHRDIKASNILLDGDFEPKVADFGLARLISACESHVSTVI----------AGTFGYIPPEYGQS 1093

  Fly  1291 AR 1292
            ||
plant  1094 AR 1095

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_524081.1 PPP1R42 <135..>242 CDD:455733
leucine-rich repeat 148..171 CDD:275380
leucine-rich repeat 172..201 CDD:275380
LRR_8 200..>246 CDD:404697 280/1237 (23%)
leucine-rich repeat 202..278 CDD:275380 11/36 (31%)
leucine-rich repeat 229..249 CDD:275380 1/2 (50%)
leucine-rich repeat 279..302 CDD:275380 5/22 (23%)
LRR 299..654 CDD:443914 114/386 (30%)
leucine-rich repeat 303..326 CDD:275380 5/22 (23%)
leucine-rich repeat 327..350 CDD:275380 6/23 (26%)
leucine-rich repeat 352..375 CDD:275380 9/22 (41%)
leucine-rich repeat 376..401 CDD:275380 8/24 (33%)
leucine-rich repeat 402..425 CDD:275380 11/38 (29%)
leucine-rich repeat 426..449 CDD:275380 6/32 (19%)
leucine-rich repeat 450..473 CDD:275380 8/22 (36%)
leucine-rich repeat 474..497 CDD:275380 10/22 (45%)
leucine-rich repeat 498..518 CDD:275380 8/20 (40%)
leucine-rich repeat 521..544 CDD:275380 4/22 (18%)
leucine-rich repeat 545..566 CDD:275380 5/20 (25%)
leucine-rich repeat 569..592 CDD:275380 6/22 (27%)
leucine-rich repeat 593..615 CDD:275380 7/22 (32%)
leucine-rich repeat 616..637 CDD:275380 5/20 (25%)
leucine-rich repeat 638..662 CDD:275380 9/32 (28%)
LRR_8 662..719 CDD:404697 19/72 (26%)
leucine-rich repeat 663..684 CDD:275380 7/22 (32%)
leucine-rich repeat 685..708 CDD:275380 6/22 (27%)
leucine-rich repeat 709..728 CDD:275380 9/32 (28%)
LRR <863..>990 CDD:443914 34/133 (26%)
leucine-rich repeat 885..908 CDD:275380 3/22 (14%)
leucine-rich repeat 909..932 CDD:275380 4/22 (18%)
leucine-rich repeat 933..956 CDD:275380 6/22 (27%)
TIR 1114..1247 CDD:214587 28/162 (17%)
EMS1NP_196345.1 PLN00113 30..1190 CDD:215061 276/1229 (22%)
leucine-rich repeat 91..114 CDD:275380 6/24 (25%)
leucine-rich repeat 115..138 CDD:275380 9/22 (41%)
leucine-rich repeat 139..163 CDD:275380 8/24 (33%)
leucine-rich repeat 164..187 CDD:275380 8/22 (36%)
leucine-rich repeat 188..211 CDD:275380 5/24 (21%)
leucine-rich repeat 212..235 CDD:275380 4/22 (18%)
PLN03150 <224..307 CDD:178695 26/83 (31%)
leucine-rich repeat 236..259 CDD:275380 8/22 (36%)
leucine-rich repeat 260..283 CDD:275380 10/22 (45%)
leucine-rich repeat 284..303 CDD:275380 7/18 (39%)
leucine-rich repeat 333..350 CDD:275380 4/16 (25%)
leucine-rich repeat 355..378 CDD:275380 6/22 (27%)
leucine-rich repeat 379..402 CDD:275380 7/22 (32%)
leucine-rich repeat 403..424 CDD:275380 7/29 (24%)
leucine-rich repeat 426..449 CDD:275380 6/22 (27%)
leucine-rich repeat 450..473 CDD:275380 7/22 (32%)
leucine-rich repeat 474..497 CDD:275380 6/22 (27%)
leucine-rich repeat 498..521 CDD:275380 4/22 (18%)
leucine-rich repeat 522..545 CDD:275380 8/56 (14%)
leucine-rich repeat 546..578 CDD:275380 8/31 (26%)
leucine-rich repeat 579..604 CDD:275380 5/34 (15%)
leucine-rich repeat 606..629 CDD:275380 2/22 (9%)
leucine-rich repeat 630..646 CDD:275380 4/15 (27%)
leucine-rich repeat 654..677 CDD:275380 9/24 (38%)
leucine-rich repeat 678..701 CDD:275380 3/22 (14%)
leucine-rich repeat 702..725 CDD:275380 4/22 (18%)
leucine-rich repeat 726..749 CDD:275380 6/22 (27%)
leucine-rich repeat 750..773 CDD:275380 5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

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