DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and AT4G23840

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_194115.3	Gene:	AT4G23840 / 828483	AraportID:	AT4G23840	Length:	597	Species:	Arabidopsis thaliana

Alignment Length:	686	Identity:	169/686 - (24%)
Similarity:	255/686 - (37%)	Gaps:	190/686 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 LVRLQQLSIQYCKLG------RLGRQVLDGL-EQLRNLTLR---THNILWPALNFEIEADAFSVT 199
            ||||  ...:.||.|      ||.|:.|:.| ..|.:..||   ...:|:|:|   :|...:||
plant     5 LVRL--CLKEACKSGDAVERWRLQRRSLESLPPHLADALLRRLLKKRLLFPSL---LEGFKYSV- 63

  Fly   200 RRLERLDL----SSNNIW-----SLPDNIFCTLSELSALNMSE----NRLQDVNELGFRDRSKEP 251
               |.:||    |.|..|     ...:.|...||:...:|.|.    ..|..:.||.. .|..:.
plant    64 ---ENIDLRGKSSVNAEWMAYIGGFVNLITLNLSDCQRINSSTLWPITGLTSLTELDL-SRCFKV 124

  Fly   252 TNGSTESTSTTESAKKSSSSSTSCS---------------LDLEYLDVSHNDFVVLPANGFGTLR 301
            |:...:...:..:.||...|.|..:               |||..|.|:..:.:.|.|     |.
plant   125 TDAGMKHLQSVVNLKKLWISQTGVTEVGISLLASLKKLSLLDLGGLPVTDQNLISLQA-----LT 184

  Fly   302 RLRVL-----SVNNNGISMIADKALSGLK--NLQILNLSSNKIVALPTELFAEQAKIIQEVYLQN 359
            :|..|     :|.|.|       |:|.||  ||..||||...|...|.....|        .|..
plant   185 KLEYLDIWGSNVTNQG-------AVSILKFSNLSFLNLSWTSITQTPNIPHLE--------CLHM 234

  Fly   360 NSISVLN-PQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDL 423
            |:.:::: |:..|:|..|:.|.||.... |...:..:|.....:..|::|...|..     ||.|
plant   235 NTCTIVSEPKTHSSLASLKKLVLSGANF-SAETESLSFTNKSCITYLDVSKTSLKN-----FSFL 293

  Fly   424 YTLQILNLRHNQLENIA--ADTFAPM----NNLHTLLLSHNKL------------KYLDAYALNG 470
            .|:  .||.|..|.:.|  .|:...:    .||..|.:|..::            ..|:..:::.
plant   294 ETM--FNLEHLDLSSTAFGDDSVGFVACVGENLKNLNVSDTQITPSGVGNLAGHVPQLETLSMSQ 356

  Fly   471 LYV--LSLLSLDNNALIGVHPDAFRNCSALQDLNLNG----------NQLKTVPL-ALRNMRHLR 522
            .:|  ||:|.:...          ..|....||.:|.          .:.|...| ||:::..|.
plant   357 TFVDDLSILLISTT----------MPCIKALDLGMNSTLGFYYLISPQEEKEKSLAALQSLTSLE 411

  Fly   523 TVDLGENMITVMEDSAFKGLGNLYG---LRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEP 584
            |:.|..   ..:.|.|..||.:|.|   |.|....|.:.|:|....||||..|.        |..
plant   412 TLSLEH---PYLGDKALSGLSSLTGLTHLSLTSTSLTDSTLHHLSSLPNLVSLG--------VRD 465

  Fly   585 GAFEMTSSIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQ--WLDLHKNR 647
            |.  :||               |||....|        .|||.:.|       ||  || |.|:.
plant   466 GV--LTS---------------NGLEKFRP--------PNRLRTLD-------LQGCWL-LTKDD 497

  Fly   648 LSSLSNRFGLDSELKLQ---TLDVSFNQLQRIGPSSIPNSIELLFLNDNL---ITTVDPDTFM-H 705
            ::.|..|:   ..:|::   ....|.:|.|.:..||.|.|...:...:|.   .:...|.:|: .
plant   498 IAGLCKRY---PHIKVRHEHADSSSLDQNQLLPRSSTPQSFGKVARRNNQRPESSVAVPRSFLDQ 559

  Fly   706 KTNLTRVDLYANQITTLDIKSLRILPVWEHR-ALPE 740
            :....|.:|.|.|.:.|.    ::|| ||.. ::||
plant   560 RVKYNREELVALQNSPLS----QLLP-WEELVSVPE 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380	9/29 (31%)
		LRR_8	171..236	CDD:290566	20/80 (25%)
		leucine-rich repeat	172..201	CDD:275380	9/31 (29%)
		leucine-rich repeat	202..278	CDD:275380	20/103 (19%)
		leucine-rich repeat	229..249	CDD:275380	6/23 (26%)
		LRR_RI	278..468	CDD:238064	54/215 (25%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	301..386	CDD:290566	27/92 (29%)
		leucine-rich repeat	303..326	CDD:275380	9/29 (31%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		LRR	350..729	CDD:227223	96/422 (23%)
		leucine-rich repeat	352..375	CDD:275380	5/23 (22%)
		leucine-rich repeat	376..401	CDD:275380	6/24 (25%)
		LRR_RI	<401..626	CDD:238064	58/258 (22%)
		leucine-rich repeat	402..425	CDD:275380	6/22 (27%)
		leucine-rich repeat	426..449	CDD:275380	6/28 (21%)
		leucine-rich repeat	450..473	CDD:275380	4/34 (12%)
		leucine-rich repeat	474..497	CDD:275380	4/22 (18%)
		leucine-rich repeat	498..518	CDD:275380	7/30 (23%)
		leucine-rich repeat	521..544	CDD:275380	7/22 (32%)
		leucine-rich repeat	545..566	CDD:275380	7/23 (30%)
		leucine-rich repeat	569..592	CDD:275380	5/22 (23%)
		leucine-rich repeat	593..615	CDD:275380	3/21 (14%)
		leucine-rich repeat	616..637	CDD:275380	4/20 (20%)
		leucine-rich repeat	638..662	CDD:275380	8/25 (32%)
		leucine-rich repeat	663..684	CDD:275380	6/23 (26%)
		leucine-rich repeat	685..708	CDD:275380	3/26 (12%)
		leucine-rich repeat	709..728	CDD:275380	5/18 (28%)
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
AT4G23840	NP_194115.3	AMN1	85..>238	CDD:187754	42/173 (24%)
		leucine-rich repeat	88..112	CDD:275381	6/23 (26%)
		leucine-rich repeat	113..137	CDD:275381	4/24 (17%)
		leucine-rich repeat	138..185	CDD:275381	12/51 (24%)
		leucine-rich repeat	186..209	CDD:275381	9/29 (31%)
		leucine-rich repeat	210..248	CDD:275381	11/45 (24%)
		leucine-rich repeat	252..273	CDD:275380	6/21 (29%)
		LRR_RI	<291..490	CDD:238064	59/253 (23%)
		leucine-rich repeat	299..323	CDD:275381	5/23 (22%)
		leucine-rich repeat	324..348	CDD:275381	3/23 (13%)
		leucine-rich repeat	349..373	CDD:275381	5/33 (15%)
		leucine-rich repeat	374..409	CDD:275381	7/34 (21%)
		leucine-rich repeat	410..433	CDD:275381	8/25 (32%)
		leucine-rich repeat	434..457	CDD:275381	6/22 (27%)
		leucine-rich repeat	458..481	CDD:275381	10/55 (18%)
		leucine-rich repeat	482..507	CDD:275381	10/35 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000